EVMS Radiation Oncology & Biophysics uses the most advanced techniques of delivering therapeutic irradiation for the treatment of malignant disease and some benign conditions. It also has its own physics and radiobiology support for patient care and tumor biology research.

The department's treatment equipment includes linear accelerators, CT simulators and treatment planning computers at all locations. A high‑dose-rate remote afterloading unit and facilities for intra-operative radiation at Sentara Norfolk General Hospital complement the therapeutic armamentarium. The Cyberknife Stereotactic Robotic linear accelerator is available at Sentara Norfolk General Hospital.

In addition to standard radiation treatments, members of the department provide the latest treatment strategies, including altered fractionation schemes, interstitial implantation, high-dose-remote afterloading by outpatient and inpatient techniques and intraoperative radiation. The department provides a full range of radiation oncology services, including external beam and radioisotope therapy. The department is also involved in institutional multidisciplinary cancer research projects, as well as national projects.