Profiles
Gerald J. Pepe, PhD
Dr. Pepe came to EVMS in 1978 as an Associate Professor in the Department of Physiology. He was named Professor and Chair in 1985 and served in that position until 2005. He also served as Associate Dean of Research from 1995 to 1997. He was appointed Dean and Provost from 2004-2012. He returned as Chair to the Department of Physiological Sciences in 2011 where he continues to teach and perform research.
Faculty Appointments
Professor and Chair, Physiological Sciences
Office Hours
By appointment only
Lewis Hall, Room 2060
Direct Phone: 757.446.5616
Fax: 757.624.2269
Undergraduate Degree
Providence College, Providence, RI, B.A. 1965
Fellowship
Senior Staff Fellow, Div. of Child Health, National Institutes of Health, Bethesda, MD, 1978
Graduate Education
University of Kansas, Lawrence, KS, Ph.D. 1970; Northeastern University, Boston, MA, M.S. 1967
Lab Location
Jones Institute, Room 340 and Room 346
Phone: 757.446.5716
Fax: 757.624.2269
Research Interests
The high incidence of human neonatal morbidity and mortality associated with low birth weight and prematurity as well as impact of the ever increasing exposure of humans to environmental endocrine disruptors indicates need for more intensive study of the mechanisms underlying the development of the primate placenta and fetus. The long-term objective of his laboratory is to improve knowledge in this area and translate findings to the human by building on our previous and ongoing in vivo and in vitro studies in the pregnant baboon demonstrating the important role of estrogen in controlling placental-fetal communication by regulating [1] placental angiogenesis and structural maturation, [2] remodeling of maternal uterine spiral arteries by extravillous trophoblast critical to uteroplacental blood flow dynamics, [3] maturation of fetal-organ systems including the adrenal gland, ovary and testis as well as tissues controlling metabolic function, and establishing the impact of these intrauterine programming actions of estrogen on physiological processes (e.g. insulin sensitivity, vascular and reproductive function) in adulthood.
Presentations and Scholarships
Dr. Pepe - Selected Publications (from list of 155)
See additional publications for Dr. Pepe on PubMed
Faculty Appointments
Professor and Chair, Physiological Sciences
Office Hours
By appointment only
Lewis Hall, Room 2060
Direct Phone: 757.446.5616
Fax: 757.624.2269
Undergraduate Degree
Providence College, Providence, RI, B.A. 1965
Fellowship
Senior Staff Fellow, Div. of Child Health, National Institutes of Health, Bethesda, MD, 1978
Graduate Education
University of Kansas, Lawrence, KS, Ph.D. 1970; Northeastern University, Boston, MA, M.S. 1967
Lab Location
Jones Institute, Room 340 and Room 346
Phone: 757.446.5716
Fax: 757.624.2269
Research Interests
The high incidence of human neonatal morbidity and mortality associated with low birth weight and prematurity as well as impact of the ever increasing exposure of humans to environmental endocrine disruptors indicates need for more intensive study of the mechanisms underlying the development of the primate placenta and fetus. The long-term objective of his laboratory is to improve knowledge in this area and translate findings to the human by building on our previous and ongoing in vivo and in vitro studies in the pregnant baboon demonstrating the important role of estrogen in controlling placental-fetal communication by regulating [1] placental angiogenesis and structural maturation, [2] remodeling of maternal uterine spiral arteries by extravillous trophoblast critical to uteroplacental blood flow dynamics, [3] maturation of fetal-organ systems including the adrenal gland, ovary and testis as well as tissues controlling metabolic function, and establishing the impact of these intrauterine programming actions of estrogen on physiological processes (e.g. insulin sensitivity, vascular and reproductive function) in adulthood.
Presentations and Scholarships
Dr. Pepe - Selected Publications (from list of 155)
See additional publications for Dr. Pepe on PubMed