Gerald J. Pepe, PhD

<p>University of Kansas, Lawrence, KS, Ph.D. 1970; Northeastern University, Boston, MA, M.S. 1967</p>

Chairman

Physiological Sciences


Lewis Hall

757.446.5619

pepegj@evms.edu


Dr. Pepe came to EVMS in 1978 as an Associate Professor in the Department of Physiology. He was named Professor and Chair in 1985 and served in that position until 2005. He also served as Associate Dean of Research from 1995 to 1997. He was appointed Dean and Provost from 2004-2012. He returned as Chair to the Department of Physiological Sciences in 2011 where he continues to teach and perform research.

Faculty Appointments

Professor and Chairman, Physiological Sciences

Office Hours

By appointment only

Lewis Hall, Room 2060

Direct Phone: 757.446.5616

Fax: 757.624.2269

Undergraduate Degree

Providence College, Providence, RI, B.A. 1965

Fellowship

Senior Staff Fellow, Div. of Child Health, National Institutes of Health, Bethesda, MD, 1978

Graduate Education

University of Kansas, Lawrence, KS, Ph.D. 1970; Northeastern University, Boston, MA, M.S. 1967

Lab Location

Jones Institute, Room 340 and Room 346

Phone: 757.446.5716

Fax: 757.624.2269

Research Interests

The high incidence of human neonatal morbidity and mortality associated with low birth weight and prematurity as well as impact of the ever increasing exposure of humans to environmental endocrine disruptors indicates need for more intensive study of the mechanisms underlying the development of the primate placenta and fetus. The long-term objective of his laboratory is to improve knowledge in this area and translate findings to the human by building on our previous and ongoing in vivo and in vitro studies in the pregnant baboon demonstrating the important role of estrogen in controlling placental-fetal communication by regulating [1] placental angiogenesis and structural maturation, [2] remodeling of maternal uterine spiral arteries by extravillous trophoblast critical to uteroplacental blood flow dynamics, [3] maturation of fetal-organ systems including the adrenal gland, ovary and testis as well as tissues controlling metabolic function, and establishing the impact of these intrauterine programming actions of estrogen on physiological processes (e.g. insulin sensitivity, vascular and reproductive function) in adulthood.

Presentations and Scholarships

Contact Dr. Pepe

Dr. Pepe - Selected Publications (from list of 155)

See additional publications for Dr. Pepe on PubMed

Faculty Appointments

Professor and Chairman, Physiological Sciences

Office Hours

By appointment only

Lewis Hall, Room 2060

Direct Phone: 757.446.5616

Fax: 757.624.2269

Undergraduate Degree

Providence College, Providence, RI, B.A. 1965

Fellowship

Senior Staff Fellow, Div. of Child Health, National Institutes of Health, Bethesda, MD, 1978

Graduate Education

University of Kansas, Lawrence, KS, Ph.D. 1970; Northeastern University, Boston, MA, M.S. 1967

Lab Location

Jones Institute, Room 340 and Room 346

Phone: 757.446.5716

Fax: 757.624.2269

Research Interests

The high incidence of human neonatal morbidity and mortality associated with low birth weight and prematurity as well as impact of the ever increasing exposure of humans to environmental endocrine disruptors indicates need for more intensive study of the mechanisms underlying the development of the primate placenta and fetus. The long-term objective of his laboratory is to improve knowledge in this area and translate findings to the human by building on our previous and ongoing in vivo and in vitro studies in the pregnant baboon demonstrating the important role of estrogen in controlling placental-fetal communication by regulating [1] placental angiogenesis and structural maturation, [2] remodeling of maternal uterine spiral arteries by extravillous trophoblast critical to uteroplacental blood flow dynamics, [3] maturation of fetal-organ systems including the adrenal gland, ovary and testis as well as tissues controlling metabolic function, and establishing the impact of these intrauterine programming actions of estrogen on physiological processes (e.g. insulin sensitivity, vascular and reproductive function) in adulthood.

Presentations and Scholarships

Contact Dr. Pepe

Dr. Pepe - Selected Publications (from list of 155)

See additional publications for Dr. Pepe on PubMed

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