The goal of this laboratory is to elucidate the cellular and molecular mechanism of the pathogenesis underlying epilepsy and glioblastoma multiforme (GBM).
We are focusing on inflammatory molecular signals as a common denominator of these diseases. We study the role of those signals in the abnormal neuronal excitability, neural damage and aberrant neuronal network formations during the development of epilepsy and GBM invasion.
We utilize data from human epilepsy and GBM, pharmacological, molecular, immunohistochemical, behavioral, in vivo and in vitro microelectrodes and brain cell culture approaches in experimental models of epilepsy and GBM.
This approach will bring a proof-of-concept evidence for potential biomarkers to anticipate seizures or tumor invasion and to identify a therapeutic target with a promise to prevent or limit them.
Since primary school, I have been deeply curious about the brain and motivated to help patients in need. This early interest has led me to develop a passion and obsession for neuroscience and neurology. I consider myself to be grateful to have had the opportunity to work with the brightest and talent leaders in the fields of neuroanatomy, neuropathology, neurology, neuradiology and neurosciences. At every stage of my education, training, and daily work, I am filled with wonder and excitement. I am constantly learning, discovering, and reshaping our understanding of the brain and its diseases. My goal is to inspire the next generation of physician-scientists and explore ways we can contribute to the relief of neurological patients.
Alberto E. Musto, Principal Investigator