Profiles
Li F. Yang, PhD
Courses Taught
- On-line Journal Club (Course Director)
- Applied Biostatistics & Bioinformatics (Bioinformatics Module)
Graduate Education
- MD, Peking University Health Science Center
- PhD, Eastern Virginia Medical School
Postdoctoral Education
- Postdoctoral training, Eastern Virginia Medical School
Lab Location
Lester Hall, Room 462
Research Interests
The Yang lab focuses on fundamental and translational research related to cancer pathogenesis, with the goals of developing innovative cancer biomarkers and therapeutic avenues to advance precision medicine of Oncology. The biological systems of her interests include tumor cells, tumor-shed entities, tumor associated cells, and tumor microenvironment. She applies a multidisciplinary platform to her research that consists of a combination of various experimental models, clinical patient samples, high-throughput multi-omics approaches, integrated bioinformatics, advanced imaging techniques, and traditional molecular and cellular biology. Efforts by Dr. Yang and her team are currently directed towards developing minimally invasive strategies for longitudinally monitoring disease progression and treatment response, dissecting cancer surfaceome to identify actionable targets, and elucidating tumor microenvironment determinants on cancer disparities and treatment resistance.
Keywords: cancer biomarkers, cancer treatments, cancer biology, glycosylation, proteomics, extracellular vesicles and particles, intercellular communication
Relevant Publications
- Correll, V.L., Otto, J.J., Risi, C., Main, B.P., Boutros, P.C., Kislinger, T., Galkin, V.E., Nyalwidhe, J.O., Semmes, O.J., Yang, L. Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis. Journal of Extracellular Vesicles, 11: e12184, 2022.
- Haynes, B.A., Yang, L., Huyck, R.W., Lehrer, E.J., Turner, J.M., Barabutis, N., Correll, V.L., Mathiesen, A., McPheat, W., Semmes, O.J., Dobrian, A.D. Endothelial-to-Mesenchymal transition in human adipose tissue vasculature alters the particulate secretome and induces endothelial dysfunction.
Arterioscler Thromb Vasc Biol.,39(10):2168-2191, 2019 - Hasegawa, T., Glavich, G.J., Pahuski, M., Short, A., Semmes, O.J., Yang, L., Galkin, V., Drake, R., Esquela-Kerscher, A. Characterization and evidence of the miR-888 cluster as a novel cancer network in prostate. Cancer Res. 16(4):669-681, 2018
- Yang, L., Dutta, S., Troyer, D.A., Lin, J.B., Lance, R.A., Nyalwidhe, J.O., Drake, R.R., Semmes, O.J. Dysregulated expression of cell surface glycoprotein CDCP1 in prostate cancer. Oncotarget, 6(41):43743-58, 2015.
- Yang, L., Nyalwidhe, J.O., Guo, S., Drake, R.R., Semmes, O.J. Targeted identification of metastasis-associated cell-surface sialoglycoproteins in prostate cancer. Molecular & Cellular Proteomics, 10(6):M110.007294, 2011.
Courses Taught
- On-line Journal Club (Course Director)
- Applied Biostatistics & Bioinformatics (Bioinformatics Module)
Graduate Education
- MD, Peking University Health Science Center
- PhD, Eastern Virginia Medical School
Postdoctoral Education
- Postdoctoral training, Eastern Virginia Medical School
Lab Location
Lester Hall, Room 462
Research Interests
The Yang lab focuses on fundamental and translational research related to cancer pathogenesis, with the goals of developing innovative cancer biomarkers and therapeutic avenues to advance precision medicine of Oncology. The biological systems of her interests include tumor cells, tumor-shed entities, tumor associated cells, and tumor microenvironment. She applies a multidisciplinary platform to her research that consists of a combination of various experimental models, clinical patient samples, high-throughput multi-omics approaches, integrated bioinformatics, advanced imaging techniques, and traditional molecular and cellular biology. Efforts by Dr. Yang and her team are currently directed towards developing minimally invasive strategies for longitudinally monitoring disease progression and treatment response, dissecting cancer surfaceome to identify actionable targets, and elucidating tumor microenvironment determinants on cancer disparities and treatment resistance.
Keywords: cancer biomarkers, cancer treatments, cancer biology, glycosylation, proteomics, extracellular vesicles and particles, intercellular communication
Relevant Publications
- Correll, V.L., Otto, J.J., Risi, C., Main, B.P., Boutros, P.C., Kislinger, T., Galkin, V.E., Nyalwidhe, J.O., Semmes, O.J., Yang, L. Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis. Journal of Extracellular Vesicles, 11: e12184, 2022.
- Haynes, B.A., Yang, L., Huyck, R.W., Lehrer, E.J., Turner, J.M., Barabutis, N., Correll, V.L., Mathiesen, A., McPheat, W., Semmes, O.J., Dobrian, A.D. Endothelial-to-Mesenchymal transition in human adipose tissue vasculature alters the particulate secretome and induces endothelial dysfunction.
Arterioscler Thromb Vasc Biol.,39(10):2168-2191, 2019 - Hasegawa, T., Glavich, G.J., Pahuski, M., Short, A., Semmes, O.J., Yang, L., Galkin, V., Drake, R., Esquela-Kerscher, A. Characterization and evidence of the miR-888 cluster as a novel cancer network in prostate. Cancer Res. 16(4):669-681, 2018
- Yang, L., Dutta, S., Troyer, D.A., Lin, J.B., Lance, R.A., Nyalwidhe, J.O., Drake, R.R., Semmes, O.J. Dysregulated expression of cell surface glycoprotein CDCP1 in prostate cancer. Oncotarget, 6(41):43743-58, 2015.
- Yang, L., Nyalwidhe, J.O., Guo, S., Drake, R.R., Semmes, O.J. Targeted identification of metastasis-associated cell-surface sialoglycoproteins in prostate cancer. Molecular & Cellular Proteomics, 10(6):M110.007294, 2011.