Julia A. Sharp, PhD

<p>MS Biology, Old Dominion University</p>
<p>PhD Biomedical Sciences, EVMS</p>

Assistant Professor

Microbiology and Molecular Cell Biology


Lewis Hall

757.446.5916

sharpja@evms.edu


Faculty Appointments

Microbiology and Molecular Cell Biology

School of Health Professions

Courses Taught

BP718/818, BT 702: Intro to Lab (Course Director)

BT 706: Advanced Molecular and Cellular Techniques (Course Director)

BT 708: Microarray Technologies

MIC 202: Medical Microbiology

MLAS 509: Biotechnology and Diagnostic Techniques

RCS 702: Molecular Biology and Genetics

MSA 503: Surgical Microbiology

Graduate Education

MS Biology, Old Dominion University

PhD Biomedical Sciences, EVMS

Postdoctoral Education

Microbiology and Molecular Cell Biology, EVMS

Lab Location

Lewis Hall 3115

Research Interests

Complement evasion; Complement inhibition (peptide delivery); the effect of stress on Complement

Presentations and Scholarships

  1. Sharp JA, Hair PS, Pallera HK, Kumar PS, Mauriello CT, Nyalwidhe JO, Phelps CA, Park D, Thielens NM, Pascal SM, Chen W, Lattanzio FA, Cunnion KM, and NK Krishna.  2015.  Peptide Inhibitor of Complement C1 (PIC1) rapidly inhibits complement activation after intravascular injection in rats. PLoS ONE 10(7): e0142466. doi: 10.1371/journal.pone.0132446
  2. Sharp JA, Whitley PH, Cunnion KM and NK Krishna. 2014. Peptide inhibitor of complement C1 (PIC1), a novel suppressor of classical pathway activation: mechanistic studies and clinical potential. Front. Immunol. 5:406. doi: 10.3389/fimmu.2014.00406
  3. Shah TA, Mauriello CT, Hair PS, Sharp JA, Kumar PS, Lattanzio FA, Werner AL, Whitley PH, Maes LA, Cunnion KM, and NK Krishna. 2014. Complement inhibition significantly decreases red blood cell lysis in a rat model of acute intravascular hemolysis. Transfusion. doi: 10.1111/trf.12695
  4. Mauriello CT, Pallera HK, Sharp JA, Woltmann Jr JL, Qian S, Hair PS, van der Pol P, van Kooten C, Thielens NM, Lattanzio FA, Cunnion KM, and NK Krishna. 2012.  A novel peptide inhibitor of classical and lectin complement activation including ABO incompatibility. Mol Immunol 53:132-139
  5. Sharp JA, Echague CG, Hair PS, Ward MD, Nyalwidhe JO, Geoghegan JA, Foster, TJ and KM Cunnion. 2012. Staphylococcus aureus surface protein SdrE binds complement regulator factor H as an immune evasion tactic. PLoS ONE 7(5): e38407. doi:10.1371/journal.pone.0038407
  6. Sharp JA and KM Cunnion. 2011. Disruption of the alternative pathway convertase occurs at the staphylococcal surface via the acquisition of factor H by Staphylococcus aureus. Mol Immunol 48:683-690

Complete Research Profile

https://researchers.evms.edu/display/person-julia-sharp

Faculty Appointments

Microbiology and Molecular Cell Biology

School of Health Professions

Courses Taught

BP718/818, BT 702: Intro to Lab (Course Director)

BT 706: Advanced Molecular and Cellular Techniques (Course Director)

BT 708: Microarray Technologies

MIC 202: Medical Microbiology

MLAS 509: Biotechnology and Diagnostic Techniques

RCS 702: Molecular Biology and Genetics

MSA 503: Surgical Microbiology

Graduate Education

MS Biology, Old Dominion University

PhD Biomedical Sciences, EVMS

Postdoctoral Education

Microbiology and Molecular Cell Biology, EVMS

Lab Location

Lewis Hall 3115

Research Interests

Complement evasion; Complement inhibition (peptide delivery); the effect of stress on Complement

Presentations and Scholarships

  1. Sharp JA, Hair PS, Pallera HK, Kumar PS, Mauriello CT, Nyalwidhe JO, Phelps CA, Park D, Thielens NM, Pascal SM, Chen W, Lattanzio FA, Cunnion KM, and NK Krishna.  2015.  Peptide Inhibitor of Complement C1 (PIC1) rapidly inhibits complement activation after intravascular injection in rats. PLoS ONE 10(7): e0142466. doi: 10.1371/journal.pone.0132446
  2. Sharp JA, Whitley PH, Cunnion KM and NK Krishna. 2014. Peptide inhibitor of complement C1 (PIC1), a novel suppressor of classical pathway activation: mechanistic studies and clinical potential. Front. Immunol. 5:406. doi: 10.3389/fimmu.2014.00406
  3. Shah TA, Mauriello CT, Hair PS, Sharp JA, Kumar PS, Lattanzio FA, Werner AL, Whitley PH, Maes LA, Cunnion KM, and NK Krishna. 2014. Complement inhibition significantly decreases red blood cell lysis in a rat model of acute intravascular hemolysis. Transfusion. doi: 10.1111/trf.12695
  4. Mauriello CT, Pallera HK, Sharp JA, Woltmann Jr JL, Qian S, Hair PS, van der Pol P, van Kooten C, Thielens NM, Lattanzio FA, Cunnion KM, and NK Krishna. 2012.  A novel peptide inhibitor of classical and lectin complement activation including ABO incompatibility. Mol Immunol 53:132-139
  5. Sharp JA, Echague CG, Hair PS, Ward MD, Nyalwidhe JO, Geoghegan JA, Foster, TJ and KM Cunnion. 2012. Staphylococcus aureus surface protein SdrE binds complement regulator factor H as an immune evasion tactic. PLoS ONE 7(5): e38407. doi:10.1371/journal.pone.0038407
  6. Sharp JA and KM Cunnion. 2011. Disruption of the alternative pathway convertase occurs at the staphylococcal surface via the acquisition of factor H by Staphylococcus aureus. Mol Immunol 48:683-690

Complete Research Profile

https://researchers.evms.edu/display/person-julia-sharp
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