Julius O. Nyalwidhe, Ph.D.

Assistant Professor

Department of Microbiology and Molecular Cell Biology

Leroy T. Canoles Jr. Cancer Research Center

Harry T. Lester Hall 424
651 Colley Avenue
Norfolk, Virginia 23501
Office: (757) 446-5682
Lab: (757) 446-5703
Email: nyalwijo@evms.edu

Teaching:

  • Biomedical Sciences Program  (BSP)
  • Molecular Integrative Biosciences (MIB)

Education:

  • Ph.D. - Philips Universität Marburg, Germany.
  • Postdoctoral Fellow - Philips Universität Marburg, Germany.

Focus Areas:

  • Cancer, Infectious Disease and Proteomics/Mass Spectrometry

Lab Members:

 

Tanya C. Burch, Ph.D.
Postdoc

  • Ph.D. - University of North Carolina
    Chapel Hill, NC

Phone: 757-446-5703
Email: burchtc@evms.edu

 

Megan T. Watson, B.S.,
Research Technician

  • B.S. - Virginia Polytechnic Institute and State University
    Blacksburg, VA

Phone: 757-446-5703
Email: watsonmt@evms.edu                                                                                        


Research Interests:

Keywords:
Cancer, Cancer Progression and Metastasis, Biomarkers, Prostate Cancer, Health Disparities, Infectious Diseases, Host-Pathogen Interactions, Protein Biochemistry, Protein Post Translational Modifications, Proteomics, Glycomics, Metabolomics, Mass Spectrometry.

Mechanisms of Cancer Pathogenesis
Dr. Nyalwidhe’s laboratory focuses on molecular biology, functional genomics and proteomic approaches to study cancer for the purposes of understanding cancer biology as well as to discover clinical biomarkers. The focus is on understanding the molecular events and signaling mechanisms that are involved in cancer progression and disease severity. The objective is to identify and disrupt signaling mechanisms that are involved in cancer progression and severity. The molecules that are involved in these mechanisms are potential diagnostic and prognostic biomarkers for disease and may also provide avenues for targeted cancer drug development. The emphasis is on mechanisms and targets that could explain cancer health disparities between different ethnic groups. Our recent research findings demonstrate the differential regulation of proteins and that their glycosylation patterns closely correlate with prostate cancer disease severity. We are also interested in determining the mechanisms of chemopreventive action of nutraceuticals against cancers. The objective is to identify and characterize the molecular targets and mechanisms of action of known nutraceuticals involved in cancer prevention.

Mechanisms of Host pathogen Interactions
The focus of this project is on understanding the mechanisms of interactions between infectious pathogens and their host cells. A major research focus is the human malaria parasite Plasmodium falciparum, which invades and develops in red blood cells to cause disease pathologies that include severe malarial anemia, nephropathy and cerebral disease. The goal is to define unique and fundamental pathways and mechanisms in the microorganisms as well as human cells that provide molecular insights, targets and therapies in neglected diseases. Additionally, we are also focusing on understanding the mechanisms of pathogenesis of a variety of other infectious agents, and viral-induced carcinomas. The emphasis is on the application of molecular biology, functional and structural proteomics and mass spectrometry techniques to functionally characterize protein post-translational modifications to determine their influence in the progression and outcome of disease.


Selected Publications:


Book Chapters:

Nyalwidhe J, Baumeister S, and Lingelbach K.
Surface biotinylation of infected erythrocytes:
In Methods in Malaria Research 5th Edition. (2008).
Ljungström, I, Perlmann, H., Schlichtherle, M., Scherf, A and Wahlgren, M (Editors).
Semmes OJ, Belgnaoui MS, Mitchell R and Nyalwidhe J0.
Application of proteomics to HTLV-1: Understanding pathogenesis and enhancing diagnostics:
In Recent Advances in Human Retroviruses: principles of replication and Pathogenesis. (2010).
Lever AML, Kuan-Teh, J and Berkhout B. (Editors).
Semmes OJ, Drake RR and Nyalwidhe J0.
Mass Spectrometry: Principles and Applications in Cancer Diagnosis and Management:
In Principles of Molecular Diagnostics and Personalized Cancer Medicine.


Patent Applications:

  • Syncollin, pancreatic triacylglycerol lipase, and other biomarkers for diabetes
    WO 2013106851 A2
    Inventors: Nadler, JL., Green-Mitchell, SM., and Nyalwidhe, J.O.