Canoles Cancer Research Center Pathologist awarded NIH grant

Story Date: Mon, 01 Jul 2013 00:00:00 EDT

Dean Troyer, MD, Pathologist in the Leroy T. Canoles Jr. Cancer Research Center, was recently awarded a $260,000 Phase I STTR grant from the NIH entitled “Targeted Imaging Mass Spectroscopy for Biomarker Detection in Human Tissues.” These grants are provided to small businesses for the commercialization of promising technologies. Antibodies are widely used in pathology to detect proteins by immunohistochemistry. This is a powerful method that localizes proteins of interest, such as HER-2 in breast cancer. The mass spectroscopy method uses antibodies that are “bar coded” with molecules that fly off when activated by a laser. This allows electronic recording of the signal, and multiple antibodies can be studied at one time. In similar methods applied to blood cells over 25 antibodies have been simultaneously utilized. This allows multiple pathways to be examined and opens the door to targeting agents more precisely to individual tumors. More effective measurement of markers of disease in human tissue biopsies can more accurately align patients with the treatment most likely to benefit them.