Professor of Cancer Biology

Department of Microbiology and Molecular Cell Biology

Leroy T. Canoles Jr. Cancer Research Center

Harry T. Lester Hall 423
651 Colley Avenue
Norfolk, Virginia 23501
Office: (757) 446-5664
Email: TangAH@evms.edu


 Teaching:

  • Tumor Biology and Cancer Metastasis
  • Advanced Cell Biology
  • Developmental Biology
  • Molecular Genetics
  • Tumor Immunology

Education

  • B.S., Fudan University
  • CUSBEA National Honor Program
  • Ph.D., The Pennsylvania State University
  • Postdoctoral Training, Howard Hughes Medical Institute (HHMI), University of California at Berkeley

Academic Positions

2002 – 2009

  • Tenure-Track Assistant Professor
    Department of Surgery, Transplantation Biology
    Mayo Clinic College of Medicine
    Rochester, MN 55905, USA

2010 - Present

  • Tenure-Track Associate Professor
    Department of Microbiology and Molecular Cell Biology
    Eastern Virginia Medical School
    Norfolk, VA 23507, USA

Lab People and Photos

The 2010 AACR-PanCAN Innovative Grant Recipient: Dr. Amy Tang with Dr. Tyler Jacks, 2010 President of the AACR's, of the Massachusetts Institute of Technology (MIT), and Julie Fleshman, JD, MBA, President and CEO of the Pancreatic Cancer Action Network. ©2010 AACR/Todd Buchanan.

Front Row: Elizaveta Svyatova, Monicah M. Njogu, Abigail C. Cole, Dr. Richard Hoefer, Ricardo Moscoso, 
Dr. Minglei Bian,
  Angela Tang-Tan, Kevin Lacy, Michael P. Lee

Back Row: Shipra Maheshwari, Justin J. Hummel, Michael Cameron Hayes, Ian Pepper

 

Robby Van Sciver, Lauren Siewertsz van Reesema, Vassilena Zheleva, Minglei Bian, Amy Tang

Postdoctoral Fellows

Minglei Bian, PhD

(September 1, 2010 – April 2017)

BS, Peking University
PhD, Peking University
Postdoctoral Fellow, EVMS (2010 – 2017)

Yang Liao, PhD

(May 28, 2008 – July 31, 2011)

BS, Fudan University
PhD, Fudan University
Postdoctoral Fellow, Mayo Clinic
(May 28, 2008 - December 30, 2009)
(Dr. Tang's Lab)
Postdoctoral Fellow, EVMS
(January 1, 2010 – July 31, 2011)

Research Associate (University of Chicago, Ben May Cancer Institute)
(August 2011 - Present) 

Atique U. Ahmed, PhD

(June 12, 2006 – October 12, 2008)

BS, Minnesota State University, Winona, MN
PhD, Open University, UK
(Jointly with the Mayo Clinic Molecular Medicine Program)
Postdoctoral Training: Mayo Clinic College of Medicine
(Mentor: Dr. Amy Tang)
Transplantation Biology, Department of Surgery

Faculty Position:
Assistant Professor of Cancer Biology
University of Chicago

Cheol Hong Park, PhD

(May 02, 2006 – May 23, 2009)

BS, Hanyang University, Seoul, Korea
MS, Hanyang University, Seoul, Korea
PhD, Hanyang University, Seoul, Korea
Postdoctoral Training: Mayo Clinic College of Medicine
(Mentor: Dr. Amy Tang)
Transplantation Biology, Department of Surgery 

Yajun Cao, PhD

(April 12, 2010 – July 31, 2011)

BS, Nanjing Agricultural University
PhD, Fudan University
Postdoctoral Fellow, EVMS
(April 12, 2010 – July 31, 2011

YingYing Liu, PhD

(September 1, 2012 – June 14, 2012)

BS, Fuzhou University
PhD, Peking University
Postdoctoral Fellow, EVMS
(September 1, 2012 – June 14, 2012)

Xiaofei Gao, PhD

(August 2, 2012- September 25, 2013)

MS, YangZhou University (2004 – 2007)
PhD, Fudan University, China (2009 – 2012)
Postdoctoral fellow, EVMS
(Aug. 2, 2012 – Sept. 25, 2013)

Clinical Fellows

Nanette R. Reed, MD

(July 2007 – June 2008)

BS, University of Notre Dame
MD, Baylor College of Medicine
MS, Mayo Graduate School
Surgical Residency: Mayo Clinic College of Medicine

Faculty Position:
Assistant Professor of Surgery
Washington University in St. Louis

Vassilena Zheleva, MD

(July 1, 2011 – June 17, 2013)

BA, Colby College
MD, Dartmouth Medical School
PGY3 Residency Training in General Surgery at EVMS
Surgical Fellowship, City of Hope, California
(August 2016 - Present)

Graduate Students

Kevin F. Kanda, MS

(July 1, 2017 to July 18, 2018)

BS, Biology, Old Dominion University
MS, Biomedical Sciences, Eastern Virginia Medical School
PhD, Cancer Biology, University of Texas at San Antonio
(August 1, 2018 – 2023)

 

Rebecca L. Schmidt, PhD

(July 1, 2005 – December, 2008)

BS, Lawrence University
(Valedictorian, Summa Cum Laude)
PhD, Mayo Clinic Graduate School
(Mentor: Dr. Amy Tang)
Postdoctoral Training: National Jewish Health

Faculty Position: 
Assistant Professor of Biology
Upper Iowa University

"Winner of the 5-Year Mayo Clinic Pobanz Family Predoctoral Fellowship, Inaugural Fellow"

Monicah M. Njogu

PhD graduate student
(July 1, 2012 – January 20, 2017)

BS, East Stroudsburg University Pennsylvania (2006)
MS, Seton Hall University New Jersey (2009)
PhD, EVMS Norfolk, VA (2011-2017)

"Awarded a 2014-2015 UNCF-Merck Graduate Science Research Dissertation Fellowship, one of just 12 exceptional students whom such awards were given in the U.S. for 2014"

Robby Van Sciver

PhD Graduate Student
(May 2014 – April 2019)

BS, Chemical Engineering, University of Virginia (2005)
Research Scientist, Ethos Pharmaceuticals (2006-2008)
Research Specialist, University of Virginia (2009-2013)
PhD, Biomedical Sciences, EVMS (2019)

Elizaveta Svyatova

PhD Graduate Student
(August 31, 2013 - present)

BS, Old Dominion University
MS, Old Dominion University/Eastern Virginia Medical School
PhD, EVMS (July 1, 2014 to present)

Justin J. Odanga

MS graduate student
(July 1, 2012 – May 18, 2013)

BS, Hampden-Sydney College, Hampden-Sydney, VA (2010)

MA, EVMS  Norfolk, VA  (2013)
(August, 2013 - Present)

Andrew J. Isbell

MS graduate student
(July 1, 2013 – May 17, 2014)

BS, United States Air Force Academy USAFA, CO, and Truman State University, Kirksville, MO (2009)
MS, EVMS,  Norfolk, VA (2014)
Medical Student, Campbell University
(August, 2014 - Present)

Xavier-Lewis Palmer

Biotechnology graduate student at EVMS

BS, Old Dominion University (2014)
MS, Biotechnology, Eastern Virginia Medical School, Norfolk, VA
(2014-2015)
PhD, Old Dominion University
(Class of 2020 Bio Engineering)

Zena Urban

MS graduate student
(August 1, 2011 – September 30, 2014)

BS, West Virginia University
MA, Boston University School of Medicine
MS, Eastern Virginia Medical School

Medical Students

Narotham Badrish

Summer 2017
2017 CHKD-EVMS Summer Scholar

MD, Eastern Virginia Medical School, Norfolk, VA
(August 2016 – May 2020)
BS, University of Virginia, Charlottesville, VA
Biomedical Engineering

Alex C. LaFever

(10/19/2016 – present)
EVMS M1 Medical Student, MD Class of 2020

MD, Eastern Virginia Medical School, Norfolk, VA
(August 2016 – May 2020)
MS, Georgetown University, Washington D.C.
(August 2014 – July 2015)
Master of Science, Physiology and Biophysics
BS, James Madison University, Harrisonburg, VA
(August 2010 – May 2014)
Bachelor of Science, Biology

Amber L. Collier

(05/01/2017 – present)
EVMS M3 medical student, MD Class of 2020

MD, Eastern Virginia Medical School, Norfolk, VA
(August 2014 – May 2018)
MS, Eastern Virginia Medical School, Norfolk, VA
(August 2013 – May 2014)
BS, George Mason University, Fairfax, VA
(2005 – 2009)
Bachelor of Science, Business Management

Shipra Maheshwari

2016 CHKD-EVMS Summer Scholar
(May of 2016 – August of 2016)
EVMS M2 medical student (2015-2019)

MD, EVMS class of 2019
BS, University of Virginia
Major in Bioengineering and Minor in Engineering Business

Michael P. Lee

Medical student at EVMS (MD class of 2019)

BS, Bioengineering, University of California
San Diego (2008-2012)
MS, Biomedical Sciences, Eastern Virginia Medical School
Norfolk, VA (2014-2015)
MD, Eastern Virginia Medical School
Norfolk, Virginia (2015-2019)

Dasom Caroline Lee

Medical student at EVMS
2015 CHKD-EVMS Summer Scholar

BS, University of California at Berkeley (2011)
MD, Eastern Virginia Medical School (2018)

Research Positions: University of California at San Francisco (2011-2012)
Stanford University (2012-2014)

Rahim M. Dhanani

Medical student at EVMS

BS, Emory University (2012)
MS, Eastern Virginia Medical School (2014)
MD, Eastern Virginia Medical School (2018)

Ian Pepper, BS

2015 Student volunteer at EVMS

BS, Virginia Tech, Blackburg, VA (2013-2015)
University of Minnesota (2012-2013)
PhD, Eastern Virginia Medical School (2016 - Present)

Drake Bishop

2014 EVMS-CHKD summer scholar
Summer 2014

AAS, Southside VA Community College (2010)
BS, Hampden-Sydney College (2014)
Major in Biology and Minor in chemistry and classical studies
MD, Eastern Virginia Medical School (2018)

"Recipient of 4 year Middleton Scholarship (2014-2018) at EVMS"

Lauren Siewertsz van Reesema, BS

2013 CHKD-EVMS Summer Scholar
Summer 2013

BS, James Madison University (2013)
MD, Eastern Virginia Medical School (2015 -2019)

Ting Chen, MS

2013 Summer Student
Summer 2013

BS, Brandeis University, Biology (2007)
MS, Eastern Virginia Medical School
Biomedical Sciences (2012)
MD, Eastern Virginia Medical School (2013 -2017)

Kristin Sica

Summer 2011

BS, Rutgers University
MA, Drexel College of Medicine
MD, Eastern Virginia Medical School (2011 - 2015)

Technicians

John A. Crooks

(August 2, 2010 – May, 13, 2011)

BS, University of California at Davis
PhD, University of Wisconsin, Madison (2011 - Present)

Michael Cameron Hayes

Research Assistant I

BS, Old Dominion University, Norfolk, VA (2011-2015)
MD, University of Virginia Medical School (2016-2020)

Lauren Siewertsz van Reesema, BS

(September 1, 2014 - Present)

BS, James Madison University (2013)
MD, Eastern Virginia Medical School (2015 -2019)

Jamie Eisner

MS graduate student
(May 1, 2014 to August, 2015)

BS, Old Dominion University (2011)
MS, University of Florida (2013)
PhD, Eastern Virginia Medical School (2015 - Present)

Bridget N. Montgomery

(July 15, 2013 – July 30, 2014)

BS, University of Virginia (UVA)

Oscar A. Gonzales

(July 5, 2011 – December 28, 2012)

BS, Longwood University
BS, Virginia Commonwealth University
Post-BS, Wake Forest University School of Medicine

Summer Scholars (Summer Undergraduate Students)

Chris Smith

Summer 2017
2017 CHKD-EVMS Summer Scholar

BS, Radford University, Radford VA
(May 2017)
Major in Biology, Minor in Chemistry

Mahelet N. Mamo

Summer 2017
2017-SPUR summer undergraduate student

BS, Longwood University, Farmville, VA
(May 2018)
Biology

Abigail C. Cole

2016 EVMS SPUR student

3rd-year Undergraduate
Major in Chemistry and Minor in Biochemistry

BS, University of Virginia (2017)

Ricky D. Moscoso

2016 summer volunteer

Freshman
Major in Biomedical Engineering, Molecular Biophysics and Biochemistry
Yale University Class of 2019

Stephen Tang

2015 EVMS Research Volunteer

Undergraduate Student, Yale University (2014-2018)

Angela Tang-Tan

2015 Student Volunteer at EVMS

High School student, Princess Anne High School,
International Baccalaureate (IB) 
Gifted and talented Program, Virginia Beach, VA
BS, University of California, Berkeley (2016-2020)

Gabriel I. Lopez

2015 SPUR student at EVMS

BS, Old Dominion University (2015)

Domonique White

2014 EVMS SPUR student

BS, Norfolk State University (NSU) 2015

Garrett Rushing

Summer Volunteer
Summer 2014

BS, Bob Jones University (2014 Senior)
Cell Biology Major and Chemistry Minor
MD, Virginia Commonwealth University (2015-2019)

Chris Rowley

Summer volunteer 2014

B.S., James Madison University (2012)
Philosophy major
Phi Beta Kappa
Old Dominion University (2014)

John Edward Fernan

2013 EVMS SPUR Student
Summer 2013

BS, University of Vermont

Sophia Blunt

Summer Student Volunteer 2012

William and Mary University (Freshman)

Russell Wilson

2012 EVMS SPUR Student
Summer of 2012

Virginia Commonwealth University (VCU) (Senior)
Major: Biochemistry

Matthew Ambler

Summer 2010

Yale University (Freshman)


 

 

Research Interests

 

Project I: Regulated Proteolysis in oncogenic ERBB/K-RAS-Mediated Tumorigenesis and Metastasis in human cancer

Dr. Tang's laboratory studies the RAS signal transduction pathway using multiple model organisms/systems including Drosophila, transgenic mice, human cancer cell lines and human cancer tissue specimens. As oncogenic RAS promotes the genesis of many human cancers, how best to contravene activated RAS signaling has been an intense area of investigation in the field of cancer biology for the past 30 years. Seven-In-Absentia (SINA), an E3 ubiquitin ligase, is an essential downstream component of the Drosophila RAS signal transduction pathway. The human homologue of SINA, SIAH, is a member of this evolutionarily highly conserved family of RING finger E3 ubiquitin ligases; however, the roles and regulation of SIAH-dependent proteolysis are not well understood in the context of RAS signal transduction in mammalian systems.

Dr. Tang's lab has accumulated evidence demonstrating the importance of proper SIAH function in mammalian K-RAS signaling. We show that by inhibiting the enzymatic activity of SIAH, and thus SIAH-mediated proteolysis, RAS-mediated neoplastic transformation and tumorigenesis can be effectively blocked in human cancer cells [Can Res 67(24):1798-810, 2007; JNCI 100(22):1606-29, 2008]. Furthermore, SIAH-deficient cells have reduced MAPK signaling, suggesting that SIAH might be involved in aberrant K-RAS signaling through a regulatory feedback loop mechanism. Thus, these studies provide an initial glimpse into the significance of the SIAH E3 ubiquitin ligase-regulated proteolysis in the K-RAS pathway during tumor initiation, progression and oncogenesis in human pancreatic cancer, lung cancer, invasive and metastatic breast cancer and hormonal-refractory prostate cancer.

Advancing understanding of the role of SIAH E3 ligases in K-RAS signaling and, more importantly, the potential to target SIAH as a novel new anti-K-RAS and anti-cancer target in the treatment of the most aggressive and the deadliest forms of human cancers represent exciting steps forward in the fields of K-RAS signaling, cancer biology and cancer therapy. Ultimately, we hope such SIAH-based anti-cancer therapies will lead to novel and efficacious treatments for human cancer patients, especially the ones with metastatic diseases.

Project II:   Innate Immunity and Cellular Defense

To understand how a host cell differentiates a pathogenic microbe from a nonpathogenic microorganism is a fundamental question in biology. Drosophila has an innate immune system that is similar to humans but is devoid of the complication of the adaptive immune system. We use the Drosophila as the model organism to study the molecular mechanism of how innate immunity is activated upon pathogen recognition. We found that the structural integrity of the sentinel receptors/innate sensors is modulated during infection and inflammation. We hypothesize that proteases release that is common during pathogen-host antagonism may provide an important cue for the host to distinguish a pathogenic versus a nonpathogenic microorganism. We are using transgenic fly models to demonstrate that protease release after pattern recognition provides a "tissue damage" signal that could alert host cells to the onset of endogenous tissue damage and exogenous pathogen invasion.

‌‌

Project III:   Genetic Screens for Anti-Cancer Drug Resistance 

The development drug/chemical resistance is a recurring problem. There is an important need for us to understand the mechanisms by which drug/chemical resistance is acquired in multicellular organisms and cancers. We will carry out genetic screens in Drosophila for resistance to several key anticancer drugs that are prone to develop resistance. This effort, coupled with genomic and microarray analyses, should help to identify the alterations of key signaling pathways that could forecast and predict drug resistance development.


Research Grants Awarded

Ongoing Research Support

 

DOD-BCRP-BC180907 “Early Detection of Tumor Relapse in Triple Negative Breast Cancer”    
Principal Investigator: Amy H. Tang, Ph.D.
Project Period: 03/01/2019 – 02/28/2022

 

2015-2019 CIT-CRCRF grant entitled “Development and commercialization of a new, sensitive and chemo-responsive anti-SIAH-based monoclonal antibody detection kit to examine and quantify the efficacy of chemotherapies in breast cancer patients with metastatic diseases in real time in VA” (MF14S-009-LS)
Principal Investigator: Amy H. Tang, Ph.D.
Project Period: 07/01/2015 – 12/31/2019 (NCE)

 

Dorothy G. Hoefer Foundation for Pancreatic Cancer Research to support the SIAH-based IHC staining to determine the prognostic value of RAS pathway biomarkers in neoadjuvant treated pancreatic cancer.
Principal Investigator: Amy H. Tang, Ph.D.
Project Period: 07/01/2016 – 06/30/2022

 

Dorothy G. Hoefer Comprehensive Breast Center Foundation for Breast Cancer Research to support the SIAH-based IHC staining to evaluate the efficacy of neoadjuvant therapy and individualized medicine in breast cancer. 
Principal Investigator: Amy H. Tang, Ph.D.
Project Period: 01/29/2015 – 12/31/2022 

 

EVMS Women’s and Infant Health (WIH) Grant Program entitled “Individualized Oncology at Neoadjuvant Setting for Late-Stage Metastatic Breast Cancer
Principal Investigator: Amy H. Tang, Ph.D.
Project Period: 09/01/2017 – 11/30/2019 (NCE)

 

Dorothy G. Hoefer Foundation for Pancreatic Cancer Research to support the SIAH-based IHC staining to determine the prognostic value of RAS pathway biomarkers in neoadjuvant treated pancreatic cancer.
Principal Investigator: Amy H. Tang, Ph.D.
Project Period: 07/01/2016 – 06/30/2017            

2014-2015 CIT-CRCRF grant entitled “Development and commercialization of a new, sensitive and chemo-responsive anti-SIAH-based monoclonal antibody detection kit to examine and quantify the efficacy of chemotherapies in breast cancer patients with metastatic diseases in real time in VA” (MF14S-009-LS)
Principal Investigator: Amy H. Tang, Ph.D.
Project Period: 07/01/2014 – 06/31/2017            

Dorothy G. Hoefer Comprehensive Breast Center Foundation for Breast Cancer Research to support the SIAH-based IHC staining to evaluate the efficacy of neoadjuvant therapy and individualized medicine in breast cancer. 
Principal Investigator: Amy H. Tang, Ph.D.
Project Period: 01/29/2013 – 01/28/2017            

NCI “Regulated Proteolysis in Cell Migration, Tumor Growth & Metastasis in Lung Cancer"  (1 R01 CA140550-01A1)
Principal Investigator: Amy H. Tang, Ph.D.
Project Period: 07/01/2010 – 06/31/2016            

NIH R21 Grant application entitled “Role of the EPS Urine-Derived MicroRNA miR-888 in Prostate Cancer Progression”
Principal Investigator: Aurora Esquela Kerscher, Ph.D.
Co-investigator: Amy H. Tang, Ph.D.
Project Period: 07/01/2014 – 06/30/2016

NIH NCI R01 - 1 R01 CA140550-06
Title: "SIAH2-Dependent Proteolysis in Cell Migration, Tumor Growth and Cancer Metastasis"
Principal Investigator:  Amy H. Tang, Ph.D.
NCI R01 Project Period: 07/01/2010 – 06/30/2016    

AACR 2010 Pancreatic Cancer Action Network- American Association for Cancer Research (AACR) Innovative Grant (AACR-PanCan #169458)
"SIAH is a novel and effective anti-K-RAS drug target in pancreatic cancer"
Principal Investigator: Amy H. Tang, Ph.D.
Project Period: 07/01/2010 - 06/30/2013

Department of Defense "Targeting SIAH E3 Ligase Downstream of the HER2/Neu/RAS Signaling Pathway to Block Highly Invasive Human Breast Cancer Tumorigenesis and Metastasis" (DOD-Idea Award-BC095305) 
Principal Investigator: Amy H. Tang, Ph.D. 
Project Period: 07/01/2010 - 06/30/2013

NIGMS "Regulated Proteolysis in the RAS Signal Transduction" (R01 GM 069922)
Principal Investigator: Amy H. Tang, Ph.D. 
Project Period: 05/01/2004 - 04/30/2011

NIH supplement "Regulated Proteolysis in the RAS Signal Transduction" (R01 GM 069922Z-05S1)
Principal Investigator: Amy H. Tang, Ph.D. 
Project Period: 09/30/2009 - 04/30/2011


Publications

White, K. A., Swier, V. J.,  Cain, J.T., Kohlmeyer, J.L., Meyerholz, D. K., Tanas, M. R., Uthoff, J., Hammond, E., Li, H., Rohret, F. A., Goeken, J. A., Chan, C.H., Leidinger, M., Umesalma, S., Wallace, M. R., Dodd, R. D., Panzer, K., Tang, A. H., Darbro, B. W., Moutal, A., Cai, S., Li, W., Bellampalli, S. S., Khanna, R., Rogers, C. S., Sieren, J. C., Quelle, D. E., and J. M. Weimer (2018) A porcine model of neurofibromatosis type 1 that mimics the human disease, JCI Insight. 2018;3(12):e120402. Published on June 21, 2018, doi:10.1172/jci.insight.120402https://doi.org/10.1172/jci.insight.120402.

Van Sciver R. E., Lee M. P., Lee C. D., Lafever A. C., Svyatova E., Kanda K., Colliver A. L., Siewertsz van Reesema L. L., Tang-Tan A. M., Zheleva V., Bwayi M. N., Bian M, Schmidt R. L., Matrisian L. M., Petersen G. M., and A. H. Tang (2018) A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology. Cancers (Basel). doi: 10.3390/cancers10050142. Review. PMID: 29757973. Cancers201810(5), 142; https://doi.org/10.3390/cancers10050142

Pepper, I., Van Sciver, R. E. and A. H. Tang (2017) Phylogenetic Analysis of the Evolutionarily Highly Conserved Family of SINA/SIAH E3 Ligases in Metazoa, BMC Evol Biol. 2017 Aug 7;17(1):182. doi: 10.1186/s12862-017-1024-x, PMID: 28784114,
https://www.ncbi.nlm.nih.gov/pubmed/28784114

Xin Jin, Yunqian Pan, Liguo Wang, Tao Ma, Lizhi Zhang, Amy H. Tang, Daniel D. Billadeau, Heshui Wu and Haojie Huang (2017) Fructose-1,6-bisphosphatase inhibits ERK activation and gemcitabine resistance in pancreatic cancer by blocking IQGAP1-MAPK interaction, Cancer Res. 2017 Jul 18, pii: canres.3143.2016. DOI: 10.1158/0008-5472.CAN-16-3143. PMID: 28720574, http://cancerres.aacrjournals.org/content/canres/early/2017/08/02/0008-5472.CAN-16-3143.full.pdf

*Siewertsz van Reesema, L. L., *Lee, M. P. Zheleva, V., Winston, J. S., O’Connor, C. F., Perry, R. R., Hoefer, R. A. and A. H. Tang (2016) RAS pathway biomarkers for breast cancer prognosis, Clinical Laboratory International (CLI), November 4 issue, pp18-23, Women’s cancer biomarkers, 2016. 
http://www.clinlabint.com/detail/clinical-laboratory/ras-pathway-biomarkers-for-breast-cancer-prognosis/


Siewertsz van Reesema, L. L., Zheleva, V., Winston, J. S., Jansen, R. J., O’Connor, C. F., Isbell, A. J., Bian, M., Qin, R., Bassett, P. T., Hinson, V. J., Dorsch, K. A., Kirby, B. W., Van Sciver, R. E., Tang-Tan, A.M., Harden, E. A., Chang, D. Z., Allen, C. A., Perry, R. R., Hoefer, R. A. and A. H. Tang. "SIAH and EGFR, two RAS pathway biomarkers, are prognostic in locally advanced and metastatic breast cancer", EBioMedicine, Online publication August 14, 2016. DOI information: 10.1016/j.ebiom.2016.08.014, NIHMS 812981, PubMed Central PMCID http://www.sciencedirect.com/science/article/pii/S2352396416303632
EVMS Press Release on August 23, 2016
http://www.evms.edu/pulse/archive/evmssentaracollaborativestudymaybenefitbreastcancerpatients.php

Susan G. Komen Friday News Flash – Komen News – on August 26, 2016

Van Sciver, R. E., Njogu, M. M., Isbell, A. J., Odanga, J. J., Bian, M., Svyatova, E., Siewertsz van Reesema, L. L., Zheleva, V., Eisner, J. L., Bruflat, J. K., Schmidt, R. L., Tang-Tan, A. M., and A. H. Tang (2016) Chapter 12 – Blocking SIAH Proteolysis, an Important K-RAS Vulnerability, to Control and Eradicate K-RAS-Driven Metastatic Cancer. Conquering RAS: From Biology to Cancer Therapy, pages 213-232.
DOI: 10.1016/B978-0-12-803505-4.00012-6.(Elsevier Academic Press).
Elsevier Inc: http://www.sciencedirect.com/science/article/pii/B9780128035054000126

 R. Qin, T. C. Smyrk, N. R. Reed, R. L. Schmidt, T. Schnelldorfer, S. T. Chari, G. M. Petersen and A. H. Tang (2015) Combining clinicopathological predictors and molecular biomarkers in the oncogenic K-RAS/Ki67/HIF-1α pathway to predict survival in resectable pancreatic cancer. British Journal of Cancer, 112: 514-522. (3 February 2015) doi:10.1038/bjc.2014.659
http://www.nature.com/bjc/journal/v112/n3/full/bjc2014659a.html
http://www.ncbi.nlm.nih.gov/pubmed/25584484

Burket, J. A., Benson, A.D., Tang, A. H. and S. I. Deutsch (2015) NMDA Receptor Activation Regulates Sociability by its Effect on mTOR Signaling Activity, Progress in Neuro-Psychopharmacology & Biological Psychiatry, 60: 60-65.
http://www.sciencedirect.com/science/article/pii/S0278584615000421

Vasilena Zheleva, Minglei Bian, Xiaofei Gao, Justin Odanga, Zena Urban, Monicah Njogu, Bruce Knudsen, Richard A. Hoefer, Roger R. Perry, Amy H. Tang (2014)
Inhibition of Established Pancreatic and Triple Negative Breast Tumor Growth by Blocking the Most Downstream Signaling Module, SIAH, in the Oncogenic ERBB/K-RAS Signaling Pathway
Journal of the American College of Surgeons 09/2014; 219(3):S136-S137. DOI:10.1016/j.jamcollsurg.2014.07.327, 4.45 Impact Factor
http://www.journalacs.org/article/S1072-7515%2814%2900863-1/abstract

Deutsch, S. I., Tang, A. H., Burket, J. A., Benson A. D. (2014).
NMDA Receptors on the Surface of Cancer Cells: Target for Chemotherapy?
Biomed Pharmacotherapy 68 (4): 493-496. PMID: 24751001 
http://www.ncbi.nlm.nih.gov/pubmed/24751001

Burket, J. A., Benson, A.D., Tang, A. H. and S. I. Deutsch (2014). 
Rapamycin Improves Sociability in the BTBR T+ Itpr3tf/J Mouse Model of Autism Spectrum Disorders. 
Brain Research Bulletin. 100: 70-75. PMID: 24295733
https://www.sciencedirect.com/science/article/abs/pii/S036192301300186X

Tang, A. H. (2013). 
Stopping metastasis in its tracks. 
International Innovation (North America -November Issue), page 42-44. ISSN 2051-8528. PMID: 23685206
www.international-innovation-northamerica.com

Burket, J. A., Benson, A.D., Tang, A. H. and S. I. Deutsch (2013).
D-Cycloserine Improves Sociability in the BTBR T+ Itpr3tf/J Mouse Model of Autism Spectrum Disorders with Altered Ras/Raf/ERK1/2 Signaling.
Brain Research Bulletin. 96: 62-70; PMID: 23685206
http://www.sciencedirect.com/science/article/pii/S0361923013000786

Tang, A. H. (2011)
Are you my friends or are you my enemies?
Self/Nonself, Immune Recognition and Signaling. 2:3, 142-146(Volume 2 Issue 3, June - December 2011).
http://www.landesbioscience.com/journals/selfnonself/02-TangSNS2-3.pdf

Schmidt, R. L., Rinaldo, F. M., Hesse, S. E., Hamada, M., Ortiz, Z., Beleford, D. T., Page-McCaw, A., Platt, J. L. and A. H. Tang. (2011)
Protease-Dependent Activation of the Drosophila IMD Pathway in Response to Gram-Negative Bacterial Infection.
Self/Nonself, Immune Recognition and Signaling 2, 34, 17882.
http://www.landesbioscience.com/journals/selfnonself/01-SchmidtSNS2-3.pdf

Podratz, J. L., Staff, N. P., Froemel, D., Wallner, A., Wabnig, F., Bieber, A. J., Tang, A. H. and A. J. Windebank. (2011) 
Drosophila melanogaster: A new model to study Cisplatin-induced neurotoxicity 
Neurobiology of Diseases 43, 330-337.
http://www.sciencedirect.com/science/article/pii/S0969996111001173

Behling KC, A. H. Tang, Freydin B, Chervoneva I, Kadakia S, Schwartz GF, Rui H, Witkiewicz AK. (2010)
Increased SIAH expression predicts DCIS progression to invasive carcinoma. 
Breast Cancer Research and Treatment, November 19 issue, pp1254-1258.
https://www.ncbi.nlm.nih.gov/pubmed/21088888

Ahmed, A. U., Schmidt, R. L., Park, C. H., Reed, N. R., Hesse, S. E. Thomas, C. F., Molina, J. R., Deschamps, C., Aubry, M. C. and A. H. Tang. (2008)
Effect of Disrupting Seven In Absentia Homolog 2 Function on Lung Cancer Cell Growth 
Journal National Cancer Institute 100, 1606-1629.
http://jnci.oxfordjournals.org/cgi/content/full/100/22/1606
.

Schmidt, R. L., Park, C. H. Ahmed, A. U., Gundelach, J.H., Reed, N. R., Cheng, S., Knudsen, B. E. and A. H. Tang. (2007)
Inhibition of RAS-Mediated Tumorigenesis by Targeting the downstream E3 Ubiquitin Ligase, SIAH. 
Cancer Research, 67, 11798-11810.
http://cancerres.aacrjournals.org/cgi/content/full/67/24/11798

Schmidt, R. L., Trejo, T. R., Plummer, T. B. Platt, J. L. and A. H. Tang. (2008)
The Infection-Induced Proteolysis of PGRP-LC Controls the IMD Activation and Melanization Cascades in Drosophila.
FASEB J.
 22, 918-929.
http://www.fasebj.org/cgi/content/full/22/3/918

Schmidt, R. L., Rinaldo, F. M., Hesse, S. E., Hamada, M., Ortiz, Z., Beleford, D. T., Page-McCaw, A., Platt, J. L. and A. H. Tang. (2009).
Protease-Dependent Activation of the Drosophila IMD Pathway in Response to Gram-Negative Bacterial Infection. 
Innate Immunity 1, 1-15.

TangA. H., G. J. Brunn, M. Cascalho and J. L. Platt. (2007)
Endogenous pathway to SIRS, sepsis and related conditions. 
Journal of Leukocyte Biology 82, 282-285. 
http://onlinelibrary.wiley.com/doi/10.1189/jlb.1206752/full

TangA. H. and J. L. Platt. (2007)
Accommodation of grafts: implications for health and disease. 
Human Immunology 68, 645-651.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703470/

Reed, N. R., Schmidt, R. L., Smyrk, T. C., Qin, R. Chari, S. T., Sarr, M. G., Grande, J. P., Petersen, G. M and A. H. Tang.
Predicting Pancreatic Cancer Patient Survival by Combining Clinical and Biomarkers and Tissue Microarrays.

G. B. Johnson, G. J. Brunn, A. H. Tang, J. L. Platt (2003).
Evolutionary Clues to the Functions of the Toll-like Family as Surveillance Receptors. 
Trends in Immunology 24, 19-24.
http://www.cell.com/trends/immunology/abstract/S1471-4906(02)00014-5

TangA. H., T. P. Neufeld, G. M. Rubin and H. -Arno J. Muller (2001).
Transcriptional Regulation of Cytoskeletal Functions and Segmentation by a Novel Maternal Pair-Rule Gene, 
lilliputianDevelopment 128, 801-813.
http://dev.biologists.org/content/128/5/801.full.pdf+html

T. P. Neufeld, A. H. Tang and G. M. Rubin (1998).
A genetic screen to identify components of the sina signaling pathway in Drosophila eye development. 
Genetics 148, 277-286. 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459784/

TangA. H., T. P. Neufeld, E. Kwan and G. M. Rubin (1997).
PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism. 
Cell 90, 459-467.
http://www.cell.com/abstract/S0092-8674(00)80506-1

G. M. Rubin, H. C. Chang, F. Karim, T. Laverty, N. R. Michaud, D. K. Morrison, I. Rebay, A. H. Tang, M. Therrien and D. A. Wassarman (1997).
Signal transduction downstream of RAS in Drosophila.
Cold Spring Habor Symp. on Quant. Biol. Volume LXII. 347-352. 
http://symposium.cshlp.org/content/62/347

TangA. H. and C.-P. D. Tu. (1995).
Pentobarbital-induced changes in Drosophila glutathione S-transferase D21 mRNA stability: gstD21 mRNA stability.
J Biol. Chem. 270, 13819-13825.
http://www.jbc.org/cgi/content/full/270/23/13819

TangA. H. and C.-P. D. Tu. (1994)
Biochemical characterization of Drosophila glutathione S-transferase D1 and D21: Drosophila DDT dehydrochlorinase 
J. Biol. Chem. 269, 27876-27884. 
http://www.jbc.org/cgi/reprint/269/45/27876

Z.-H. Zhang, H.-Z. Liu, A.H. Tang and Y.-D. You (1988)
The Effect of hemoglobin on the fluidity of human erythrocyte membrane. 
Acta Biophysics Sinica 4, 129-133.


Student Accomplishments

Robert E. Van Sciver, EVMS 5th-year PhD Student

Robby won a nationally competitive 2018 ASBMB Graduate and Postdoctoral Travel Award ($1,000.00) to attend the 2018 American Society for Biochemistry and Molecular Biology (ASBMB) Annual Meeting at the San Diego Convention Center, San Diego, CA 92101 (April 21-25, 2018).
This is Robby’s 4th National Travel Award

Robby won a nationally competitive 2018 Experimental Biology Travel Award ($1,000.00)from the Histochemical Society (HCS) to attend the 2018 Experimental Biology (EB2018)Annual Meeting at the San Diego Convention Center, San Diego, CA 92101 (April 21-25, 2018).
This is Robby’s 5th National Travel Award

Importantly, Robby is also invited to give an oral presentation at the ASBMB/EB Spotlight Session. His oral presentation is entitled “Seven-in-Absentia (SINA) Family E# Ligases in Development and Cancer Biology” in the Mechanisms of G Protein Signaling Spotlight Session on Tuesday, April 24 at 2:30 pm. 

Shipra Maheshwari, EVMS M3 MD student 

Shipra Maheshwari was the one-and-only MD student to win the prestigious 2017 State ACP Prize among a large number of medical residents and clinical fellows in Virginia. Shipra won a fully expense paid trip to attend the 2018 National American College of Physicians (ACP) Internal Medicine Meeting in New Orleans, LA. Shipra’s oral presentation is entitled "Molecular Mechanisms of Heightened Cellular Stress and Increased Cellular Death in Response to Oncogenic ERBB/K-RAS Inhibition in Human Cancer Cells.” 

Congratulations to Shipra, and Robby for their outstanding national presentations for EVMS.