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Larry D. Sanford , PhD

    • Title:
    • Professor

    • Role:
    • Faculty

    • Faculty Appointments:
    • Additional Certifications:
    • Focus Areas:
    • Office Location:
    • Lewis Hall

    • Undergraduate Education:
    • Graduate Education:
    • MS  (Physiological Psychology)   1985   University of Georgia


      PhD   (Physiological Psychology)  1988  University of Georgia

    • Postdoctoral Education:
    • National Multi‑site Training Program for Basic Sleep Research,  1989 - 1992.   Post‑doctoral Scholar status in Neurophysiology at University of California at Los Angeles; training at the University of Pennsylvania.


      University of Pennsylvania, 1988 - 1989.   Postdoctoral training in the study of the brain mechanisms of sleep, Mentor: Dr. Adrian R. Morrison.

    • Medical Education:
    • Residency:
    • Fellowship(s):
    • Board Certification(s):
    • Affiliation(s):
    • Research Interests:
    • Primary Specialty:
    • Hospital:
    • Courses Taught:
    • Medical Neuroscience (medical school)


      Co-director, Introduction to Animal Biomedical Science  (graduate program), 2013 - Present


      Faculty, Concepts in Research Design  (graduate program), 2010 - 2013


      Faculty, Cardiovascular and Metabolic Function and Dysfunction  (graduate program), 2011 - 2012


      Basics of Sleep Neurobiology, Special Topics  (graduate program),  2007


    • Current Projects:
    • Bio:
    • Professor, Department of Pathology and Anatomy, Eastern Virginia Medical School,   2004 to Present


      Professor, Department of Internal Medicine (Joint Appointment), Eastern Virginia Medical School,   2006 - Present


      Associate Professor, Eastern Virginia Medical School,  1999 - 2004


      Research Assistant Professor of Neuroscience, University of Pennsylvania,  1994 - 1999


      Lecturer, University of Pennsylvania,  1991 - 1994


      Research Associate, University of Pennsylvania,  1988 - 1991


      Research Technician, University of Georgia,  1987 ‑ 1988

Selected Publications

Wellman LL, Fitzpatrick ME, Kuzmina, OY, Sutton AM, Williams, BL and Sanford, LD. (2017). The basolateral amygdala can mediate the effects of fear memory on sleep independently of fear behavior and the peripheral stress response. Neurobiology of Learning and Memory. 137: 27-35.

Machida, M. Wellman, LL, M, Fitzpatrick, ME, Kuzmina, O, Sutton, AM, Lonart, G and Sanford, LD. (2017). Brief optogenetic inhibition of the basolateral amygdala in mice alters effects of stressful experiences on rapid eye movement sleep. SLEEP, 40(4). doi: 10.1093/sleep/zsx020.

Ciavarra, RP, Lundberg, P, Machida, M, Ambrozewicz, MA, Wellman, LL, Breving, K., Steel, C, and Sanford, LD. (2017). Early Gene Activation Initiates Neuroinflammation Prior to VSV Neuroinvasion: Impact on Antiviral Responses and Sleep. Journal of Neuroimmunology, 303:31-42. DOI: 10.1016/j.jneuroim.2016.12.002.

Cardier, B., Goranson, H. T., Casas, N., Lundberg, P.S.  Erioli, A., Takaki, R., Nagy, D., Ciavarra, R., and Sanford, L.D., (2017). Modeling the Peak of Emergence in Systems: Design and Katachi. Progress in Biophysics and Molecular Biology, 131: 213-241.

Machida M, Lonart G, Sanford, LD. (2018). Effects of stressor controllability on transcriptional levels of c-fos, Arc and BDNF in mouse amygdala and medial prefrontal cortex. NeuroReport, 29:112-117.

Wellman LL, Fitzpatrick ME, Sutton AM, Williams, BL, Machida, M, and Sanford, LD. (2018). Antagonism of corticotropin releasing factor in the basolateral amygdala of resilient and vulnerable rats: Effects on fear-conditioned sleep, temperature and freezing. Hormones and Behavior, 100: 20-28.

Ciavarra, RP, Machida, M, Weaver T, Pearson, A, Kennedy, K, Yu, M, Wellman, LL, Lundberg, PS, Sanford, LD. (2018). Controllable and uncontrollable stress differentially impact pathogenicity and survival in a mouse model of viral encephalitis. Journal of Neuroimmunology, 319: 130-141.