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Patric Sven J. Lundberg , PhD

    • Title:
    • Associate Professor

    • Role:
    • Faculty

    • Faculty Appointments:
    • Additional Certifications:
    • Focus Areas:
    • Herpes simplex virus 1 (HSV-1)

    • Office Location:
    • Lewis Hall

    • Undergraduate Education:
    • Graduate Education:
      • PhD, Cellular and Molecular Biology, University of Wisconsin, Madison, WI
    • Postdoctoral Education:
      • Postdoctoral Training, COH/Beckman Research Institute, Duarte, CA
    • Medical Education:
    • Residency:
    • Fellowship(s):
    • Board Certification(s):
    • Affiliation(s):
    • Research Interests:
    • Dr. Lundberg's laboratory works on the immune response to the agent behind common cold sores, herpes simplex virus 1 (HSV-1). HSV-1 is a neurotropic pathogen that, as part of the normal course of infection, enters into a dormant state in the infected neuron. When disturbed through stress (sunburn, physical, mental), HSV-1 can reactivate. This is why patients almost always experience cold sores in the same location; that is, where the infected neuron connects to the skin surface. However, there are several areas of human HSV-1 related disease with the potential for much more dire consequences than an irritating blister.

      When HSV-1 infects the cornea (and subsequently, the brain), the pathology that results is directly tied to the quality of the immune response during acute infection. In the case of sensitive tissues, such as the eye and the central nervous system (CNS), this means an immune response of appropriate strength under suitable control to avoid “collateral” damage.

      Unfortunately, some patients still suffer the consequences of an overly exuberant inflammatory response during HSV-1 infection at these sites. Current focus is on the role of macrophages in the acute inflammation that develops within the CNS of susceptible individuals during HSV-1 infection. To do this, Dr. Lundberg's lab uses a mouse infection model to study very early changes in gene expression in the CNS and uses this information to understand why severe pathology develops in some strains of mice while others can control the infection without significant tissue destruction.

    • Primary Specialty:
    • Hospital:
    • Courses Taught:
      • Bioinformatics (Course Director)
      • Biostatistics for Biomedical Sciences (Course Director)
      • Concepts in Cell Biology and Physiology
      • Concepts in Research Design, Medical Microbiology and Immunology (MMI)
      • Medical Master Library Research Thesis
      • Applied Biotechnology Internship

      Biomedical Sciences Program Tracks: Molecular Integrative Biosciences (MIB), Molecular and Cellular Biology

    • Current Projects:
    • Bio: