The Biotechnology master’s program is an accelerated curriculum of 16 months. The program offers a unique balance of hands-on training in a diverse set of research technologies and solid theoretical training in molecular and cellular biology and experimental design. This innovative program includes a six-month research internship, which can be completed in an EVMS research laboratory, in the EVMS Molecular Core Laboratory or through one of our biotechnology industry partners. Students gain a range of applied research training in disease models, bioprocessing, virology, molecular diagnostics, regenerative medicine, imaging and immunology. 

Course Sequence

Semester 1

  • Molecules to Cells (2 credits)
  • Molecular and Cellular Techniques (2 credits)
  • Introduction to the Laboratory (2 credits)
  • Cell Communication and Signaling (3 credits)
  • Laboratory Management (1 credit)
  • Introduction to Animal Biomedical Research (2 credits)

Semester 2

  • Advanced Molecular and Cellular Techniques (2 credits)
  • Applied Bioinformatics and Biostatistics (3.5 credits)
  • Microscopy & Imaging Techniques (2 credits)
  • Proteomic Technology (2 credits)
  • Flow Cytometry (2 credits)
  • Research Design (1 credit)
  • Introduction to Drug Discovery (1 credit)
  • Techniques Journal Club (1 credit)

Semester 3

  • Internship (on- or off-campus) (3 credits)
  • Online Journal Club (1 credit)

Semester 4

  • Internship (continues) (6 credits)
  • Online Journal Club (1 credit)

Total: 39.5 credits

 

EVMS Biotechnology Master’s Program Curriculum

 

Pre-Matriculation

Introduction to the Research Literature (on-line module)

Designed to train students in the interpretation of research literature. Students will assess the introduction, methods, results and discussion sections of journal articles.

 

Fall Semester Year 1

 

Molecules to Cells (BT 722, 2 credits)

The course provides a foundation in cellular and molecular biology, DNA and RNA structure and function, protein synthesis, and regulation of gene expression.

 

Molecular and Cellular Techniques (BT723, 2 credits)

Lectures cover topics in molecular cloning and analysis, detection systems including PCR and real time PCR, working with proteins, basics of cell culture.

 

Introduction to the Laboratory (BT702, 2 credits)

Intensive laboratory course will introduce students to basic research techniques, including DNA purification, subcloning, polymerase chain reaction, and cell culture methods.

 

Laboratory Management (BT704, 1 credit)

Students will learn how laboratory practices and procedures must comply with national, state, and local regulations when conducting research in the academic and biotech sectors. Students will become familiar with: (1) Good Laboratory Practices; (2) the Institutional Research Board, Institutional Biosafety Committee, Institutional Animal Care and Use Committee, and Environmental Health and Safety (Chemical & Radiation Safety); (3) Responsible conduct in research; (4) Intellectual property; (5) Research and regulatory affairs in the Biotechnology sector; and (6) Communication skills (how to prepare a resume and strengthen job interview skills).

 

Cell Communication and Signaling (BT724, 3 credits)

This is a foundational course covering basic cell membrane functions, cell signaling, cell specialization, histology and immunology. 

 

Introduction to Animal Biomedical Research (BT705, 2 credits)

This course will teach students important aspects of working with animals in the biomedical research setting.  Student will learn: (1) Ethical and welfare aspects of working with Laboratory animals. (2) State and federal regulations overseeing the laboratory animal field. (3) The general aspects of husbandry and care of laboratory animals, including common diseases and signs of diseases.  (4) Common animal models. (5) How to design and develop an animal research protocols. (6) Handling of common laboratory species (rats, mouse and rabbits).  (7) Introduction to specific common animal research procedures. (8) Biosecurity and potential zoonotic diseases in the biomedical research setting.

 

            Semester Credits: 12

 

Spring Semester Year 1

 

Advanced Molecular & Cellular Techniques (BT719, 2 credits)

Methods of gene manipulation and mutagenesis and immunological techniques will be discussed. Topics include deletion and site-directed mutagenesis, chimeras, use of linkers and expression tags, SDS polyacrylamide gel electrophoresis, in vitro transcription and translation.

 

Microscopy and Imaging Techniques (BT707, 2 credits)

This is a hands-on, technical course that will focus on developing microscopy and imaging skills.  The course will provide basic instruction and practice in electron microscopy, confocal and fluorescence microscopy, immunofluorescence, and image analysis.

 

RNA Sequencing (BT740, 1.5 credits) This laboratory course is designed to provide students a basic understanding of the techniques used to profile gene expression at a large scale. Both microarrays and RNA sequencing are commonly employed tools to interrogate RNA expression. The course will discuss these tools with a focus on RNA sequencing.

 

Proteomic Technologies (BT709, 2 credits)

Laboratory course will give students an introduction to basic proteomic techniques, including 2D-gel electrophoresis and mass spectrometry.

 

Applied Bioinformatics & Biostatistics (BT730, 3.5 credits)

Provide an introductory overview of the concepts behind and practical use of bioinformatics & statistical analysis as it relates to the life sciences with an emphasis on modern medicine and biology.

 

Flow Cytometry (BT711, 2 credits)

Course covers basic knowledge and main applications of flow cytometry, and contains both lectures/tutorials and laboratory work.  The students will learn: (1) Principles of flow cytometry: instrumentation for flow cytometry; probes for flow cytometry; quality control; and instrument maintenance. (2) Basic skills: flow cytometric protocol design; sample preparation; data analysis and presentation. (3) Major applications of flow cytometry in biomedical research and diagnostics.

 

Introduction to Drug Discovery (BT 720, 1 credit)

This course will teach students the basic pharmacological principles, fundamental issues in drug discovery, theories of drug action, and the process of drug development.      

 

Research Design (BT712, 1 credit)

This course will introduce the students to the concept of research design and the Scientific Method, relate research design to the NIH grant format and introduce the students to research design focused on various biotechnologies through presentation of a published article by a faculty member who will lead the discussion. A second meeting, in which the students will analyze the research design in the material presented, will follow the faculty presentation.

 

Techniques Journal Club (BT713, 1 credit)

Seminar presentations by students in various research areas: e.g., tumor biology, infectious diseases, immunology, molecular cell biology, cardiovascular and reproductive physiology, endocrinology and neuroscience. Journal articles emphasizing the latest innovative techniques and instrumentation used for biological and medical research are discussed and critiqued.

 

                Semester Credits: 16

 

Summer Semester Year 1

 

Internship (BT714, 3 credits)

Mentored internship at an academic research laboratory or in the biotechnology sector focusing on advanced biotechnical training.

 

On-Line Journal Club (BT715, 1 credit)

The Biotechnology program is unique in that after an intensive on-campus experience, students then complete a 6-month on-campus or off-campus internship. This on-line journal club is designed to fulfill three primary objectives: (1) maintain student contact with the primary institution and class cohort while fulfilling their internship requirement; (2) continue the process of life-long learning that is an essential component of scientific research; and (3) enhance their internship experience by discussing journal articles related to their internship research focus.

 

                Semester Credits: 4

 

Fall Semester Year 2

 

Internship (BT716, 6 credits)

Mentored internship at a biotechnology company or in a research laboratory focusing on advanced biotechnical training.

 

On-Line Journal Club – continued (BT718, 1 credit)

 

                Semester Credits: 7

 

Program Total = 39 credits

 

*The Biotechnology Master’s Research Internship Presentation: Students will return to EVMS sometime during their last month in the program and present to the EVMS community what they have learned during their research internships in academic labs and the biotechnology industry - as required for completion of the EVMS Biotechnology Master’s Degree.