Biomedical Sciences, PhD Program Course Descriptions
BP700. Cell Structure and Function. 4 credits. The course provides a foundation in cellular and molecular biology, including cell structure, cell physiology, DNA and RNA structure and function, protein synthesis, and regulation of gene expression.
BP703 or 803. Integrated Metabolism and Nutrition. 4 credits. Prerequisite: BP702/802. Biochemistry of carbohydrates, glycolysis, citric acid cycle, oxidative phosphorylation, lipids, nitrogen metabolism, heme metabolism, iron, calcium, vitamins, and nutrition.
BP708 or 808. Medical Neuroscience. Lecture and laboratory; 5 credits. Survey course in neuroscience. Basic structure and function of the nervous system is covered with clinical emphasis on problem solving and lesion localization.
BP717 or 817. Research Techniques. 2 credits. Lectures covering topics in molecular cloning and analysis, detection systems including PCR and real time PCR, working with proteins, basics of cell culture.
BP718 or 818. Introduction to the Laboratory. 2 credits. Intensive laboratory course introducing students to basic research techniques, including DNA purification, subcloning, polymerase chain reaction, and cell culture methods.
BP719 or 819; 720 or 820; 821 or 822. Biomedical Sciences Lab Rotation I, II, III. 2 credits each. Laboratory rotations with a pre-designated faculty member in which the student obtains hands-on experience. Designed for students to sample different types of research models, techniques, and subject matter.
BP722 or 822. Bioinformatics. 1 credit. Introduction tobasic concepts in bioinformatics. Use of Incogen and Vector NTI software and tools on the NCBI website. Lecture and computer laboratory will cover topics such as DNA analysis tools, PCR primer design, motif analysis, similarity searches, restriction enzyme analysis, multiple sequence alignments, protein sequence identification, phylogenetic tools and public databases.
BP727. Genomics/Microarray Technology. 1 credit. Laboratory course providing hands-on introduction to microarray technology, including experimental design, slide spotting, sample labeling, hybridization and data analysis.
BP728. Proteomic Technology. 1 credit. Laboratory course: introduction to proteomic techniques, including 2D-gel electrophoresis and mass spectrometry.
BP729. Applied Biotechnology Internship. 3-8 credits. Mentored internship ina research laboratory with a focus on advanced biotechnical training. Research Master's program. Applied Biotechnology Option students only
BP732 or 832. Biomedical Sciences Seminar (Journal Club). 1 credit. Pass/fail grading only. Seminar presentations by students in various research areas: e.g., tumor biology, infectious diseases, immunology, molecular cell biology, cardiovascular and reproductive physiology, endocrinology and neuroscience. Journal articles describing major scientific advances are discussed and critiqued. (Offered fall and spring each year)
BP736 or 836. Biostatistics for Biomedical Sciences. 3 credits.
BP741 or 841. Introduction to the Research Literature. 1 credit. Designed to train students in the interpretation of research literature. Students will assess the introduction, methods, results and discussion sections of journal articles.
BP734 or 834. Concepts in Research Design. 3 credits. Students will learn how to design and write a realistic research proposal and a will gain a general understanding of how different techniques can be used to address a wide range of research questions. Students will gain experience in small group presentation, evaluation and discussion of current scientific literature.
BP735 or 835. Advanced Proteomics. 2 credits. Prerequisites: BP702/802 and 703/803. Selected topics in current proteomic techniques and applications to the biomedical sciences: particularly mass spectrometry-based approaches applied to large scale proteome analyses and application to biomedical research topics, with emphasis on structure/function characterizations.
BP748 or 848. Advanced Cell Biology. 1 credit. Prerequisite: BP702 or 802. Topics in contemporary cell and molecular biology, including the molecular genetic basis of normal and aberrant cell growth, transcription, translation, signal transduction, oncogenes, and growth factors.
BP749 or 849. Molecular and Cellular Immunology. 2 credits. Major molecular and cellular events required for an immune response. Regulation of the immune response and its impact on immunological memory. Regional immunology and protection against pathogenic organisms.
BP752 or 852. Animal Virology. 3 credits. Overview of molecular pathogenesis of medically-important human viruses. Topics include virus entry, replication, virus-host interactions, persistence, and transformation. The interplay between viruses and the host immune response is also discussed, along with vaccine strategies. Emphasis is on discussion of the primary research literature.
BP754 or 854. Tumor Biology. 3 credits. Student presentations and faculty lectures on the cellular and molecular basis of cancer. Students will learn the basis and application of experimental approaches used in contemporary cancer research.
BP758 or 858. Cardiovascular and Metabolic Function and Dysfunction. 3 credits. A multi-disciplinary approach focused on current concepts of the genetic, molecular and cell biological bases of processes leading to cardiovascular and metabolic diseases through lectures and critical presentation of papers.
BP761 or 861. Essentials of Physiology. 3 credits. A comprehensive introduction to integrative organ system physiology and homeostatic regulatory mechanisms. Interrelationships of structure and function are reinforced. Review of classical research papers in physiology by students is required.
BP762 or 862. Advanced Molecular and Cellular Techniques. 3 credits. Methods of gene manipulation and mutagenesis and immunological techniques. Topics include deletion and site directed mutagenesis, chimeras, use of linkers and expression tags, SDS polyacrylamide gel electrophoresis, in vitro transcription and translation, cell culture, transfection and methods of protein analysis.
BP771 or 871. Advanced Endocrinology. 3 credits. Basic topics in endocrinology, including hormone synthesis, receptors and intracellular signaling, and hormonal feedback loops. Original research articles will be discussed to clarify these principles in the context of endocrine systems.
BP773 or 873. Responsible Conduct in Science. 1 credit. Series of lectures exposing graduate students to moral and ethical dilemmas in biomedical sciences. The course will also expose students to peer review processes related to submission of grants and manuscripts.
BP776 or 876. The Mammalian Ovary. 3 credits. Examination of the formation and cyclical changes within the mammalian ovary, with emphasis on the endocrine and paracrine factors which regulate adult ovarian function.
BP777 or 877. Endocrine and Reproductive Physiology. 2 credits. Basic principles of endocrinology and reproduction, including hormones, receptors, and feedback regulation. Covers major organs and their function in humans, as well as special topics of current clinical interest.
BP798. Research. 1-6 credits. Laboratory research leading to preparation of a M.S. thesis.
BP799. Thesis. 1-6 credits. Review of the literature, analysis of data and writing the M.S. thesis.
BP865. Introduction to Drug Discovery. 1 credit. An overview of general mechanisms of drug action and to understand principles of drug discovery and development.
BP895. Special Topics in Biomedical Sciences. 1-3 credits. Guided readings and discussions of current research topics. Prerequisites: approval of instructor.
BP898. Research. 1-9 credits. Laboratory research leading to preparation of a Ph.D. dissertation.
BP899. Dissertation. 1-9 credits. Review of the literature, analysis of data and writing the Ph.D. dissertation.