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Jorge L. Jacot , PhD

    • Title:
    • Assistant Professor

    • Role:
    • Faculty

    • Faculty Appointments:
    • Additional Certifications:
    • Focus Areas:
    • Office Location:
    • Lewis Hall

    • Undergraduate Education:
    • Montgomery College, Rockville, MD

      AA,  General Education: Mathematics & Science



      University of Maryland, Catonsville, MD

      BA,  Biological Science



    • Graduate Education:
    • University of Maryland School of Medicine

      MS,  1988,  Dept. of Anatomic Pathology


      Uniformed Services University of the Health Sciences (USUHS)

      F. Edward Hebert School of Medicine, Bethesda, MD

      PhD,  1993,  Dept. of Physiology



    • Postdoctoral Education:
    • Medical Education:
    • Residency:
    • Fellowship(s):
    • National Institutes of Health (NIH),  Bethesda, MD

      Research Fellowship-National Eye Institute

      1993 - 1998

    • Board Certification(s):
    • Affiliation(s):
    • Research Interests:
    • Patents and Copyrights

      Jacot JL, O Neill JT, Reinisch L. Noninvasive method for quantitation of oxyhemoglobin saturation by near-infrared reflectance spectrophotometry (application No. US1991000713212 filed 6/11/91, issued 6/15/93).


      Sredy J, Jacot JL.  Methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis using substituted indolealkanoic acids. (No. 99,156-A).


      Vinik AI, JacotJL. Nutraceuticals for the treatment of neuropathy (submitted May 12, 2005). 


      Multi-year Consortium Budget Preparation and Calculation Worksheet Computer Program.  Certificate of Registration, June 19, 2006.



      Marketed Accomplishments

      NutriNerve:  A combination of several dietary supplement nutraceuticals prepackaged in a formulation designed for the treatment of neuropathies associated with diabetes.


      Novel Aldose Reductase Inhibitor: Discovery of a highly potent and selective Aldose Reductase Inhibitor with IND FDA-submission and Phase I clinical trials for the treatment of chronic diabetic complications.



      Outstanding Performer Scientist IPD/IDD Achievement Award  (2001)


      NIH Fellows Award for Research Excellence (1996)


      Recipient of ARVO Travel Fellowship Grant (1994 & 1996)


      Outstanding Poster Presentation Award Graduate Research Colloquium, USUHS (1992)


      Honorable Mention (1990) & Recipient (1991): The Emma L. Bockman Memorial Award for Excellence in Cardiovascular/Cancer Research



    • Primary Specialty:
    • Hospital:
    • Courses Taught:
    • Current Projects:
    • Bio:
    • Previous and Present Professional Positions


      Assistant Professor

      Dept. Pathology and Anatomy, Physiological Sciences

      Eastern Virginia Medical School

      2007 - present


      Assistant Professor

      Dept. of Internal Medicine

      Eastern Virginia Medical School (EVMS)

      2004 - 2008


      Assistant Professor

      Dept. of Physiological Sciences

      Eastern Virginia Medical School (EVMS)

      2004 - 2008


      Teaching Assistant/Instructor

      Human Anatomy & Physiology

      Univ. of Maryland at Baltimore (UMBC)

      1985 - 1989



      Pharmaceutical Experience

      Assistant Director

      Institute for Pharmaceutical Discovery (IPD): Division of Biological Science Division and Comparative Medicine.  Led an interdisciplinary research team in a multi-million dollar project for development of proprietary drug. 

      Evaluated physiological parameters in animal models for drug efficacy and for clinical end-points.

      Developed biomarkers for assay development and screening.  Experience with medical/regulatory writing and FDA IND submissions.



      Research Scientist-Biology Department-Institutes for Pharmaceutical Discovery (IPD).

      Team Leader of R&D projects.




      Other Employment

      President and CEO

      Angioceutics International, LLC

      2011 - present


      Founder and senior managing partner

      Yolar International Hospitality, LLC

      2010 - present


      Dept. of Health & Human Services

      Commission of Public Health.Washington D.C.



      Medical Consultant

      HCX, Washington D.C.



      Vol. State of MD Emergency Medical Tech/Paramedic Assistant

      BCC Rescue Squad

      1982 - 1984



Selected Publications


Van Zandt MC, Jones ML, Gunn DE, Geraci LS, Jones H, Sawicki DR, Sredy J, Jacot JL,   DiCioccio T, Petrova T, Mitschler A, Podjarny AD.  Discovery of 3-[(4,5,7-Trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (Lidorestat) and Cogeners as Highly    Potent and Selective Inhibitors of Aldose Reductase for Treatment of Chronic Diabetic Complications.  J. Med. Chem 2005, 48, 3141-3152.

Glover JP, Jacot JL, Basso MD, Hohman TC, Robison, WG Jr.  Retinal capillary dilation: Early diabetic-like retinopathy in the galactose-fed rat model.  Journal of Ocular Pharmacology & Therapeutics, 16(2):167-172, 2000. 

Robison, WG Jr, Jacot JL, Katz ML, Glover JP.  Retinal Vascular Changes Induced by the Oxidative Stress of Alpha-Tocopherol Deficiency Contrasted with Diabetic Microangiopathy. Journal of Ocular Pharmacology & Therapeutics, 16(2):109-120, 2000.

Jacot JL, O'Neill T.J., Scandling D.M., West S.D., McKenzie J.E. Nitric Oxide Modulation of Retinal, Choroidal, and Anterior Uveal Blood Flow in Newborn Piglets.  Journal of Ocular Pharmacology & Therapeutics 14(5):473-489, 1998.