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Elena V. Galkina , PhD , FAHA

    • Title:
    • Associate Professor

    • Role:
    • Faculty

    • Faculty Appointments:
    • Additional Certifications:
    • Focus Areas:
    • Mechanisms of atherosclerosis, immune response in type 2 diabetes

    • Office Location:
    • Lewis Hall

    • Undergraduate Education:
    • Graduate Education:
    • Ph.D. - Institute for Experimental Medicine, Saint-Petersburg, Russia

    • Postdoctoral Education:
    • Postdoctoral Training - National Institute for Medical Research, MRC, London, UK
      Postdoctoral Training - University of Virginia, Charlottesville, VA

    • Medical Education:
    • Residency:
    • Fellowship(s):
    • Board Certification(s):
    • Affiliation(s):
    • Research Interests:
    • Our laboratory is interested in the involvement of the immune system in the development and progression of atherosclerosis, the disease that is the leading cause of heart attacks, stroke, and peripheral vascular disease. Our research is focused on understanding how atherosclerotic conditions affect immune cell functions, and how the immune system is involved in the regulation of the chronic inflammation within the artery wall and systemically in circulation and secondary lymphoid organs. One of the projects is focused on the effects of atherosclerotic conditions on T regulatory cell differentiation, stability, and functions. We study the regulation of the reciprocal balance between suppressor T regulatory cells and pro-inflammatory Th17 and Th1 cells, and synergistic effects of Th1 and Th17 cells in the development and progression of atherosclerosis. We also investigate a role of IL-17 cytokine family members in atherogenesis with a specific focus on IL-17C.

      In addition to our work on the immune response in atherosclerosis, our laboratory has also become involved in the studies devoted understanding of mechanisms of type 2 diabetes-accelerated atherosclerosis. We are particularly interested in the transcription factor STAT4 and its role in the regulation of the immune response in aortas upon conditions of insulin resistance and type 2 diabetes. Another aspect of our research is to study the function of dendritic cells and B cells in the development of type 2 diabetes. We have recently discovered that type 2 diabetic human islets have elevated population of activated B cells. We are exploring what is the role of B cells in type 2 diabetes and how these cells might affects health and functions of islets.

    • Primary Specialty:
    • Hospital:
    • Courses Taught:
    • Biomedical Graduate Students:
      ‌ Essentials in Physiology
      ‌ Cardiovascular and Metabolic Function and Dysfunction
      ‌ Introduction to the Research Literature
      ‌ Biomedical Sciences Seminar (Journal Club)
      ‌ Concepts in Research Design
      ‌ Biomedical Sciences Program Track: Molecular Integrative Biosciences (MIB)

      Medical Students:
      ‌ Medical Microbiology and Immunology

      Medical Masters Students:
      ‌ Medical Masters Library Thesis Research Paper

    • Current Projects:
    • Bio:
    • Dr.Galkina currently serves on the NHLBI Vascular Cell and Molecular Biology Study Section (VCMB). Dr.Galkina is a member of the American Heart Association ATVB Women’s Leadership Committee. She is also a Fellow of the American Heart Association.