Xiaoli Zhao, PhD

<p>2006, PhD, UMDNJ-Rutgers, Physiology & Integrative Biology</p>

Associate Professor

Physiological Sciences


Lewis Hall

757.446.5784

zhaox@evms.edu


Fellowship

2000, MS, ShanXi Medical University (China), Pediatric Neurology

Graduate Education

2006, PhD, UMDNJ-Rutgers, Physiology & Integrative Biology

Postdoctoral Education

2010, Postdoc, UMDNJ, Physiology

Lab Location

Lewis Hall 2008 & 2012

Research Interests

Cell injury and repair in pulmonary diseases

Lung cells experience daily mechanical stress and their capacity to rescue plasma membrane stress failure is critical for cell survival particularly during lung diseases. I am interested in studying the role of lung cell injury and repair in the pathogenesis, progression and prognosis of acute lung injury (ALI) and pulmonary fibrosis (PF). I am particularly interested in identifying membrane repair molecules in lung epithelial and endothelial cells and the mechanisms of these molecules to repair the lung cells. I am also actively developing therapies targeting cell injury for the treatment of ALI and PF.

Immune responses of the lung resident cells in pulmonary diseases

Immune responses are key components for the pathogenesis of a variety of lung diseases including pneumonia, asthma and lung cancer. I am interested in exploring the contribution of the lung epithelial cells and alveolar macrophages in these immune responses and in identifying rate-limiting components/molecules that determine the scale and direction of these immune responses.

Current Projects

R01HL116826 Targeting membrane repair in deformation-induced lung injury

Presentations and Scholarships

Selected Publications

1. Nagre NN, Wang S, Kellett T, Kanagasabai R, Deng J, Nishi M, Shilo K, Oeckler RA, Yalowich JC, Takeshima H, Christman JW, Hubmayr RD, Zhao X. TRIM72 modulates Caveolar endocytosis in repair of lung cells. Am J Physiol Lung Cell Mol Physiol. 2015 Dec 4:ajplung.00089.2015. doi: 10.1152/ajplung.00089.2015.
2. Kim SC, Kellett T, Wang S, Nishi M, Nagre N, Zhou B, Flodby P, Shilo K, Ghadiali S.N., Takeshima H, Hubmayr R.D. and Zhao X. Trim72 is required for effective repair of alveolar epithelial cell wounding. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15;307(6):L449-59.
3. Zhao X*, Moloughney J, Zhang S, Komazaki S and Weisleder N*. Orai1 mediate exacerbated Ca2+ entry in dystrophic skeletal muscle. PLoS One. 2012;7(11):e49862. *Corresponding author.
4. Weisleder N, Takizawa N, Lin P, Wang X, Cao C, Zhang Y, Tan T, Ferrante C, Zhu H, Chen PJ, Yan R, Sterling M, Zhao X, Hwang M, Takeshima M, Cai C, Cheng H, Takeshima H, Xiao RP, Ma J. Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy. Sci Transl Med. 2012 Jun 20;4(139):139ra85.
5. Park KH, Ma J, Brotto L, Brotto M and Zhao X. Ex vivo assessment of contractility, fatigability and alternans in murine skeletal muscle. J. Vis. Exp. (69), e4198
6. Zhao X, Yamazaki D, Kakizawa S, Pan Z, Takeshima H, Ma J. Molecular architecture of Ca (2+) signaling control in muscle and heart cells. Channels (Austin). 2011 Sep 1;5(5).
7. Thornton AM*, Zhao X*, Weisleder N, Brotto LS, Bougoin S, Nosek TM, Reid M, Hardin B, Pan Z, Ma J, Parness J, Brotto M. Store-Operated Ca2+ Entry (SOCE) Contributes to Normal Skeletal Muscle Contractility in young but not in aged skeletal muscle. Aging (Albany NY);3(6):621-34. 2011. *equal contribution.

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Fellowship

2000, MS, ShanXi Medical University (China), Pediatric Neurology

Graduate Education

2006, PhD, UMDNJ-Rutgers, Physiology & Integrative Biology

Postdoctoral Education

2010, Postdoc, UMDNJ, Physiology

Lab Location

Lewis Hall 2008 & 2012

Research Interests

Cell injury and repair in pulmonary diseases

Lung cells experience daily mechanical stress and their capacity to rescue plasma membrane stress failure is critical for cell survival particularly during lung diseases. I am interested in studying the role of lung cell injury and repair in the pathogenesis, progression and prognosis of acute lung injury (ALI) and pulmonary fibrosis (PF). I am particularly interested in identifying membrane repair molecules in lung epithelial and endothelial cells and the mechanisms of these molecules to repair the lung cells. I am also actively developing therapies targeting cell injury for the treatment of ALI and PF.

Immune responses of the lung resident cells in pulmonary diseases

Immune responses are key components for the pathogenesis of a variety of lung diseases including pneumonia, asthma and lung cancer. I am interested in exploring the contribution of the lung epithelial cells and alveolar macrophages in these immune responses and in identifying rate-limiting components/molecules that determine the scale and direction of these immune responses.

Current Projects

R01HL116826 Targeting membrane repair in deformation-induced lung injury

Presentations and Scholarships

Selected Publications

1. Nagre NN, Wang S, Kellett T, Kanagasabai R, Deng J, Nishi M, Shilo K, Oeckler RA, Yalowich JC, Takeshima H, Christman JW, Hubmayr RD, Zhao X. TRIM72 modulates Caveolar endocytosis in repair of lung cells. Am J Physiol Lung Cell Mol Physiol. 2015 Dec 4:ajplung.00089.2015. doi: 10.1152/ajplung.00089.2015.
2. Kim SC, Kellett T, Wang S, Nishi M, Nagre N, Zhou B, Flodby P, Shilo K, Ghadiali S.N., Takeshima H, Hubmayr R.D. and Zhao X. Trim72 is required for effective repair of alveolar epithelial cell wounding. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15;307(6):L449-59.
3. Zhao X*, Moloughney J, Zhang S, Komazaki S and Weisleder N*. Orai1 mediate exacerbated Ca2+ entry in dystrophic skeletal muscle. PLoS One. 2012;7(11):e49862. *Corresponding author.
4. Weisleder N, Takizawa N, Lin P, Wang X, Cao C, Zhang Y, Tan T, Ferrante C, Zhu H, Chen PJ, Yan R, Sterling M, Zhao X, Hwang M, Takeshima M, Cai C, Cheng H, Takeshima H, Xiao RP, Ma J. Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy. Sci Transl Med. 2012 Jun 20;4(139):139ra85.
5. Park KH, Ma J, Brotto L, Brotto M and Zhao X. Ex vivo assessment of contractility, fatigability and alternans in murine skeletal muscle. J. Vis. Exp. (69), e4198
6. Zhao X, Yamazaki D, Kakizawa S, Pan Z, Takeshima H, Ma J. Molecular architecture of Ca (2+) signaling control in muscle and heart cells. Channels (Austin). 2011 Sep 1;5(5).
7. Thornton AM*, Zhao X*, Weisleder N, Brotto LS, Bougoin S, Nosek TM, Reid M, Hardin B, Pan Z, Ma J, Parness J, Brotto M. Store-Operated Ca2+ Entry (SOCE) Contributes to Normal Skeletal Muscle Contractility in young but not in aged skeletal muscle. Aging (Albany NY);3(6):621-34. 2011. *equal contribution.

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