Patric Sven J. Lundberg, PhD

<ul>
<li><strong>PhD, Cellular and Molecular Biology</strong>, <em>University of Wisconsin, Madison, WI</em></li>
</ul>

Associate Professor

Microbiology and Molecular Cell Biology


Lewis Hall

757.446.5174

lundbeps@evms.edu


I am a viral pathogenesis researcher that has transitioned over the past 5-6 years to focus on bioinformatics and systems biology. I am the lead bioinformaticist on a dozen federal, foundation, and institutional-funded projects, including a current P01 project component "“Ovulation and Luteal Formation in Rodents, Monkeys, And Women” (PD: Curry, Project #2 “Angiogenesis in the Primate Ovulatory Follicle”, PI: Duffy; NICHD P01 HD071875  09/01/14-08/31/19). I created the Bioinformatics Analytics Core (BAC) at EVMS in late 2015, to better justify the time I have spent on these collaborations (Bioinformatics Analytics Core) and I remain its Director. Additionally, I am Course Director of the required graduate courses in Biostatistics and Bioinformatics, which I have merged and expanded for the Graduate School.
 
My analytics approach is driven by systems biology conceptually and using the methods I have developed in my own work, I translate small to large dataset bioinformatically in collaborations to create testable pathways and hypotheses in a diverse selection of research areas. Thus, my skills also include a formal understanding of diverse and complex disease systems such as diabetes, sleep and immune function, microbiome disruption, reproduction and ovulation control, atherosclerosis, radiation effects on cognition, and progressive multifocal leukoencephalopathy.

Courses Taught

  • Course Developer & Co-Director, Applied Biostatistics and Bioinformatics, EVMS School of Health Professions

  • Thread Leader, Virology, EVMS Care Forward Curriculum

  • Group Leader, Urinary Tract Infection Laboratory, EVMS Care Forward Curriculum

  • Lecturer, Hormones & Reproductive Health: Viral Paths Reprod. System, EVMS Care Forward Curriculum

  • Lecturer, Heart, Lung & Kidney: Para & Orthomyxoviruses, EVMS Care Forward Curriculum

  • Group Leader, Staphylo-/Streptococcus Laboratory, EVMS Care Forward Curriculum

  • Lecturer, General Mechanism of Disease: Viral Pathogenesis, EVMS Care Forward Curriculum

  • Lecturer, General Mechanism of Disease: Vaccines, EVMS Care Forward Curriculum

  • Lecturer, Gastrointestinal System and Metabolism: Mucosal Immunity, EVMS Care Forward Curriculum

  • Lecturer, Gastrointestinal System and Metabolism: Hepatitis Viruses, EVMS Care Forward Curriculum

  • Lecturer, RCS Program, Molecular Biology & Genetics: Antibodies, EVMS Care Forward Curriculum

  • Contributor, Gastrointestinal System and Metabolism: Upper GI Infections, EVMS

  • Contributor, Muscle, Skin, Bone: Viral and Fungal Skin Infections, EVMS

  • Lecturer, Foundational Sciences II: T&B Cell Receptor & Development, EVMS

  • Lecturer, : Antibodies, Clinical & Diagnostic Techniques, EVMS Clinical Embryology

  • Lecturer, Biotechnology and Diagnostic Techniques, EVMS Laboratory Animal Science Program

  • Lecturer, Concepts in Research Design, EVMS School of Health Professions

Biomedical Sciences Program Tracks: Molecular Integrative Biosciences (MIB), Molecular and Cellular Biology

Undergraduate Degree

  • B.A. in Biology (Honors), Bard College, Annandale-on-Hudson, NY

Graduate Education

  • PhD, Cellular and Molecular Biology, University of Wisconsin, Madison, WI

Postdoctoral Education

  • Division of Virology, City of Hope's Beckman Research Institute, Duarte, CA

Lab Location

Lewis Hall 3057

Research Interests

  • Bioinformatics and Systems Biology
  • Herpes Simplex Virus 1 (HSV-1)
  • Encephalitis
  • Triggers of CNS inflammation
  • Traumatic Brain Injury

Current Projects

  • Angiogenesis in the Primate Ovulatory Follicle
  • Pathway Analysis of Macrophage Responses to SIV
  • Analysis of RNA Seq Data from Human Islet Explant Cultures
  • Minority Men’s Health Initiative: Prostate Cancer Disparities in African American Men
  • Effects on Gene Regulation Following Depomedroxyprogesterone Acetate (Depo-Provera) in the Human Vaginal Mucosa
  • HTLV Blot 2.4 Post-Market Clinical Study
  • Neuroinflammation and Epigenetic Control of the Central Nervous System
  • Ingenuity Pathway Analysis of Proteomic Protein Expression Quantification in Irradiated Rats with Cognitive Impairment

Presentations and Scholarships

 

  • Ciavarra, P., Machida, M., Lundberg, P. S., Gauronskas, P., Wellman, L. L., Steel, C., and Sanford, L. D. (2018) Controllable and uncontrollable stress differentially impact pathogenicity and survival in a mouse model of viral encephalitis. Journal of Neuroimmunology 319 (2018) 130–141.
  • Cardier, B, Goranson, HT, Casas, N, Lundberg, P, Erioli, A, Takaki, R, Nagy, D, and Sanford, LD. (2017) Modeling the peak of emergence in systems: Design and katachi, Prog Biophys Mol Bio 131:213-241 (https://doi.org/10.1016/j.pbiomolbio.2017.08.014).
  • Cardier, B., Sanford, LD, Goranson, HT, Lundberg, P, Ciavarra, RP, Devlin, K, Cassas, N, and Erioli, A. (2017) Modeling the Resituation of Memory in Neurobiology and Narrative, AAAI Publications Science of Intelligence: Computational Principles of Natural and Artificial Intelligence, Spring 534-40, Technical Report SS-17-07 (www.aaai.org/ocs/index.php/SSS/SSS17/paper/view/15381)
  • Ciavarra RP, Lundberg P, Machida M, Ambrozewicz MA, Wellman LL, Breving K, Steel C, Sanford LD. (2017) Early gene activation initiates neuroinflammation prior to VSV neuroinvasion: Impact on antiviral responses and sleep. J Neuroimmunol. Feb 15;303:31-42.
  • Butcher, MJ , Filipowicz, A, Waseem, TC, McGary, C, Magilnick, N, Boldin, M, Lundberg, PS, and Galkina E. (2016) Atherosclerosis-driven Treg plasticity results in the formation of a dysfunctional subset of plastic IFNγ+ Th1/Tregs. Circulation Research. 119:1190-1203.

Courses Taught

  • Course Developer & Co-Director, Applied Biostatistics and Bioinformatics, EVMS School of Health Professions

  • Thread Leader, Virology, EVMS Care Forward Curriculum

  • Group Leader, Urinary Tract Infection Laboratory, EVMS Care Forward Curriculum

  • Lecturer, Hormones & Reproductive Health: Viral Paths Reprod. System, EVMS Care Forward Curriculum

  • Lecturer, Heart, Lung & Kidney: Para & Orthomyxoviruses, EVMS Care Forward Curriculum

  • Group Leader, Staphylo-/Streptococcus Laboratory, EVMS Care Forward Curriculum

  • Lecturer, General Mechanism of Disease: Viral Pathogenesis, EVMS Care Forward Curriculum

  • Lecturer, General Mechanism of Disease: Vaccines, EVMS Care Forward Curriculum

  • Lecturer, Gastrointestinal System and Metabolism: Mucosal Immunity, EVMS Care Forward Curriculum

  • Lecturer, Gastrointestinal System and Metabolism: Hepatitis Viruses, EVMS Care Forward Curriculum

  • Lecturer, RCS Program, Molecular Biology & Genetics: Antibodies, EVMS Care Forward Curriculum

  • Contributor, Gastrointestinal System and Metabolism: Upper GI Infections, EVMS

  • Contributor, Muscle, Skin, Bone: Viral and Fungal Skin Infections, EVMS

  • Lecturer, Foundational Sciences II: T&B Cell Receptor & Development, EVMS

  • Lecturer, : Antibodies, Clinical & Diagnostic Techniques, EVMS Clinical Embryology

  • Lecturer, Biotechnology and Diagnostic Techniques, EVMS Laboratory Animal Science Program

  • Lecturer, Concepts in Research Design, EVMS School of Health Professions

Biomedical Sciences Program Tracks: Molecular Integrative Biosciences (MIB), Molecular and Cellular Biology

Undergraduate Degree

  • B.A. in Biology (Honors), Bard College, Annandale-on-Hudson, NY

Graduate Education

  • PhD, Cellular and Molecular Biology, University of Wisconsin, Madison, WI

Postdoctoral Education

  • Division of Virology, City of Hope's Beckman Research Institute, Duarte, CA

Lab Location

Lewis Hall 3057

Research Interests

  • Bioinformatics and Systems Biology
  • Herpes Simplex Virus 1 (HSV-1)
  • Encephalitis
  • Triggers of CNS inflammation
  • Traumatic Brain Injury

Current Projects

  • Angiogenesis in the Primate Ovulatory Follicle
  • Pathway Analysis of Macrophage Responses to SIV
  • Analysis of RNA Seq Data from Human Islet Explant Cultures
  • Minority Men’s Health Initiative: Prostate Cancer Disparities in African American Men
  • Effects on Gene Regulation Following Depomedroxyprogesterone Acetate (Depo-Provera) in the Human Vaginal Mucosa
  • HTLV Blot 2.4 Post-Market Clinical Study
  • Neuroinflammation and Epigenetic Control of the Central Nervous System
  • Ingenuity Pathway Analysis of Proteomic Protein Expression Quantification in Irradiated Rats with Cognitive Impairment

Presentations and Scholarships

 

  • Ciavarra, P., Machida, M., Lundberg, P. S., Gauronskas, P., Wellman, L. L., Steel, C., and Sanford, L. D. (2018) Controllable and uncontrollable stress differentially impact pathogenicity and survival in a mouse model of viral encephalitis. Journal of Neuroimmunology 319 (2018) 130–141.
  • Cardier, B, Goranson, HT, Casas, N, Lundberg, P, Erioli, A, Takaki, R, Nagy, D, and Sanford, LD. (2017) Modeling the peak of emergence in systems: Design and katachi, Prog Biophys Mol Bio 131:213-241 (https://doi.org/10.1016/j.pbiomolbio.2017.08.014).
  • Cardier, B., Sanford, LD, Goranson, HT, Lundberg, P, Ciavarra, RP, Devlin, K, Cassas, N, and Erioli, A. (2017) Modeling the Resituation of Memory in Neurobiology and Narrative, AAAI Publications Science of Intelligence: Computational Principles of Natural and Artificial Intelligence, Spring 534-40, Technical Report SS-17-07 (www.aaai.org/ocs/index.php/SSS/SSS17/paper/view/15381)
  • Ciavarra RP, Lundberg P, Machida M, Ambrozewicz MA, Wellman LL, Breving K, Steel C, Sanford LD. (2017) Early gene activation initiates neuroinflammation prior to VSV neuroinvasion: Impact on antiviral responses and sleep. J Neuroimmunol. Feb 15;303:31-42.
  • Butcher, MJ , Filipowicz, A, Waseem, TC, McGary, C, Magilnick, N, Boldin, M, Lundberg, PS, and Galkina E. (2016) Atherosclerosis-driven Treg plasticity results in the formation of a dysfunctional subset of plastic IFNγ+ Th1/Tregs. Circulation Research. 119:1190-1203.
Submit a Profile Update