Professional Experiences

• Interim Chairman, Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, 9/06-present
• Professor, Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, 7/87-present
• Associate Professor, Department of Physiology and Biophysics, Louisiana State University, Shreveport, LA, 11/81-8/85
• Assistant Professor, Department of Physiology and Biophysics, University of Tennessee, Memphis, TN, 7/74-10/81

Education

• Ph.D., University of Missouri, Columbia, MO, 6/71
• B.A., St. Louis University, St. Louis, MO, 6/65

Publications

Viol AW, Prewitt RL, Doviak M, Britt LD. (2005) Endotoxin releases a substance from the aorta that dilates an isolated arteriole by up-regulating INOS. J Surg Res. 127(2):106-111

Dobrian AD, Schriver SD, Khraibi AA, Prewitt RL.  (2004) Pioglitazone prevents hypertension and reduces oxidative stress in diet-induced obesity. Hypertension. 43:1-9

Campsen PJ, Snyder JG, Prewitt RL, Britt, LD.  (2004) Endotoxin releases a precursor to vasodilation from large veins in an NFkB dependent manner. J Surgical Research. 116: 151-155

Dobrian AD, Schriver SD, Lynch T, Prewitt RL. (2003) Effect of salt on hypertension and oxidative stress in a rat model of diet-induced obesity. Am J Physiol Renal Physiol. 285:F619-F628

Prewitt RL, Rice DC, Dobrian AD. (2002) Adaptation of resistance arteries to increases in pressure. Microcirculation. 9:295–304

Snyder GJ, Prewitt RL, Campsen J, Britt LD. (2002) Inhibitors of NF-κB block endotoxin induced vasodilation of isolated rat skeletal muscle arterioles. Shock. 17(4):304-307

Rice DC, Dobrian AC, Schriver SD, Prewitt RL. (2002) Src autophosphorylation is an early event in pressure-mediated signaling pathways in isolated resistance arteries. Hypertension. 39[part 2]:502-507

Prewitt RL. (2002) Autoregulation of blood flow, endothelial nitric oxide synthase, and microvascular rarefaction. Editorial Commentary. J Hypertension. 20:177-178

Tan BB, Prewitt RL, Britt LD. (2001) Interleukin-10 prevents loss of tone in rat skeletal muscle arterioles exposed to endotoxin. J Surg. Res. 100:110-115

Dobrian AD, Schriver SD, Prewitt RL. (2001) Role of angiotensin II and free radicals in blood pressure regulation in a rat model of renal hypertension. Hypertension. 38:361-366

Wesselman JP, Dobrian AD, Schriver SD, Prewitt RL . (2001) Src tyrosine kinases and extracellular signal-regulated kinases 1/2 mitogen-activated protein kinases mediate pressure-induced c-fos expression in cannulated rat mesenteric small arteries. Hypertension. 37:955-960

Research Interests & Funding

• Vascular Remodeling and Circumferential Wall Stress Mechanotransduction of a pressure stimulus in isolated resistance arteries
• Obesity-related hypertension
• Phenotype regulation of cultured human aortic smooth muscle cells
• NIH Grant HL69726, Resistance Artery Remodeling in Hypertension, 2002-2006

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