Faculty Ali A. Khraibi, Ph.D. Professor Lewis Hall, 2172 Office: (757) 446-5605 Email: Khraibaa@evms.edu

Professional Experiences

• Professor, Physiology, Eastern Virginia Medical School, Norfolk, VA, 2001-present
• Associate Professor of Physiology, Department of Obstetrics and Gynecology, University of Illinois, Chicago, IL, 1996-2001
• Associate Professor, Physiology and Biophysics, Mayo Medical School, Rochester, MN, 1995-1996
• Assistant Professor, Physiology and Biophysics, Mayo Medical School, Rochester, MN, 1990-1995
• Senior Research Fellow, Renal and Cardiovascular Physiology, Mayo Clinic and Foundation, Rochester, MN, 1986-1990
• Postdoctoral Fellow, Physiology/Pharmacology, Wake Forest Medical School, Winston-Salem, NC, 1984-1986

• Ph.D., University of Mississippi School of Medicine, Jackson, MS, 1984
• M.S., University of Mississippi, University, MS, 1980
• B.S., University of Mississippi, University, MS, 1978

Yu T, Khraibi AA. (2006) Renal interstitial hydrostatic pressure and natriuretic response to high doses of angiotensin II in pregnant rats. Am J Hypertension. 19:300-305

Khraibi AA, Dobrian AD, Yu T, Solhaug MJ, Billiar RB. (2005) Role of RIHP and renal tubular sodium transporters in volume retention of pregnant rats. Am J Hypertens. 18(10):1375-1383

Yu T, Khraibi AA. (2005) Natriuretic response to direct renal interstitial volume expansion (DRIVE) in pregnant rats. Am J Hypertens. 18(6):851-857

Tang D, Yu T, Khraibi AA. (2004) Cardiovascular and renal characteristics, and responses to acute volume expansion of a rat model of diabetic pregnancy. Life Sci. 74(23):2909-2918

Tang D, Yu T, Khraibi AA. (2004) Effects of insulin on renal interstitial hydrostatic pressure and natriuretic response to volume expansion in diabetic rats. Am J Physiol Regu Integr Comp Physiol. 286(4):R751-R755

Dobrian, AD, Schriver SD, Khraibi AA, Prewitt RL. (2004) Pioglitazone prevents hypertension and reduces oxidative stress in diet-induced obesity. Hypertension 43:48-56

Khraibi AA, Yu T, Tang D. (2003) Role of nitric oxide in the natriuretic and diuretic responses in pregnant rats. Am J Physiol Renal Physiolo. 285:F938-F944

Khraibi AA. (2002) Renal interstitial hydrostatis pressure and sodium excretion in hypertension and pregnancy. J Hypertension. 20(suppl 3):S21-S27

Khraibi AA, Solhaug MJ, Dobrian AD, Berndt. (2001) Renal interstitial hydrostatis pressure and natriuretic responses to volume expansion in pregnant rats. Am J Physiol Renal Physiol. 282:F821-F825

Khraibi AA, Liang M, Berndt T. (2001) Role of gender on renal interstitial hydrostatic pressure and sodium excretion in rats. Am J Hypertension 14(9):893-896

Khraibi AA, Ramsey CR, Heublein DM, Berndt TJ, Knox FG. (2001) Role of plasma renin activity and the renal nerves in the natriuresis of L-NMMA infusion in rats. Life Sci. 69(10):1123-1131

Khraibi AA. (2000) Renal interstitial hydrostatic pressure and pressure natriuresis in pregnant rats. Am J Physiol Renal Physiol. 279:F353-F357

Nuwayhid B, Nguyen T, Khraibi AA. (1998) Maternal Physiology. IN: Essential of Obstetrics and Gynecology, third edition, N.F. Hacker and J.G. Moore, eds., W.B. Sanders Company, Orlando, FL, pp 85-99.

Khraibi AA, Knox FG. (1995) Regulation of fluid and electrolyte balance. IN: Medical Physiology, R.A. Rhoades and G.A. Tanner, eds., Little Brown and Company, Boston, MA, pp 446-463

Khraibi AA. (1995) Role of the renal nerves in the natriuresis of L-NMMA infusion in SHR and WKY rats. Am J Physiol. 269 (Renal Fluid Electrolyte Physiol. 38):F17-F21

Khraibi AA. (1994) Inhibition of nitric oxide causes exaggerated natriuresis in spontaneously hypertensive rats. Am J Physiol. 266 (Renal Fluid Electrolyte Physiol. 35):F762-F766

Khraibi AA, Norman RA Jr., Dzielak DJ. (1984) Chronic immunosuppression attenuates hypertension in Okamoto spontaneously hypertensive rats. J Physiol. 247 (Heart Circ. Physiol. 16):H722-H726

My research interests focus broadly on the role of the kidney in hypertension and in pregnancy. Specifically, I have been studying the role of the kidney in the development and maintenance of hypertension and the renal adaptations to essential hypertension. In addition, I am currently studying the mechanisms that are responsible for the renal hemodynamic and excretory functions, as well as cardiovascular adaptations during pregnancy and during diabetes mellitus.

TITLE: "Renal Interstitial Hydrostatic Pressure in Pregnancy"
PERIOD OF GRANT: 2000-2004
TOTAL AMOUNT OF AWARD: $748,163
SOURCE OF FUNDING: National Institute of Child Health and Human Development

TITLE: “Regulation of Developmental Renal Hemodynamics”
PERIOD OF GRANT: 2002-2006
TOTAL AMOUNT OF AWARD: $1,493,481
SOURCE OF FUNDING: National Institutes of Health, National Heart, Lung, and Blood Institute

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