Professional Experiences

• Research Assistant Professor, Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, 2006-present
• Instructor, Strelitz Diabetes Institute, Eastern Virginia Medical School, Norfolk, VA, 2004-2006
• Research Physiologist, Veterans Administration Medical Center, West Haven, CT, 1999-2003
• Biologist, Renal Cell Biology Section, National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD, 1995-1998
• Intramural Research Training Award (IRTA Fellowship), Renal Cell Biology Section, NIDDK, National Institutes of Health, Bethesda, MD, 1994-1995
• Postdoctoral Fellow, Department of Medicine, Division of Endocrinology, University of North Carolina School of Medicine, Chapel Hill, NC, 1993-1994

Education

• Ph.D., Uniformed Services University of the Health Sciences, Bethesda, MD, 1993
• B.S., University of Scranton, Scranton, PA, 1988

Honors and Awards

• Alpha Epsilon Delta Honor Society (1987)
• The Emma L. Bockman Memorial Award for Excellence in Cardiovascular/Cancer Research (1991)
• National Institutes of Health Staff Recognition Award (1997)

Publications

Doi SQ, Jacot TA, Sellitti DF, Hirszel P, Mirata MM, Striker GE, Striker LJ. (2000) Growth hormone increases inducible nitric oxide synthase expression in mesangial cells. J Am Soc Nephrol. 11:1419-1425

Mozes MM, Böttinger EP, Jacot TA, Kopp JB. (1999) Renal expression of fibrotic matrix proteins and of TGF-β Isoforms in TGF-β Transgenic Mice. J Am Soc Nephrol. 10:271-280

Elliot SJ, Striker LJ, Stetler-Stevenson W, Jacot TA, Striker GE. (1999) Pentosan polysulfate decreases proliferation and net extracellular matrix production in mouse mesangial cells. J Am Soc Nephrol. 10:62-68

Lenz O, Striker LJ, Jacot TA, Elliot SJ, Killen PD, Striker GE. (1998) Glomerular endothelial cells synthesize collagens but little gelatinase A and B. J Am Society Nephrol. 9:2040-2047

Jacot TA, Clemmons DR. (1998) Effect of glucose on insulin-like growth factor binding protein-2 proteolysis. Endocrinology. 139:44-50

Jacot TA, Striker GE, Stetler-Stevenson MA, Striker LJ. (1996) Mesangial cells from transgenic mice with progressive glomerulosclerosis exhibit stable, phenotypic changes including undetectable MMP-9 and increased type IV collagen. Laboratory Investigation. 75:791-799

Lo CS, Tamaroglio T, Zhang J. (1995) Regulation of Fibronectin by Platelet-Derived Growth Factors in Cultured Rat Thoracic Aortic Smooth Muscle Cells. Journal of Biomedical Science. 2:63-69

Tamaroglio TA, Lo CS. (1994) Regulation of fibronectin by insulin-like growth Factor-I (IGF-I) in cultured rat thoracic aortic smooth muscle cells and glomerular mesangial cells. Experimental Cell Research. 215:338-346

Research

Research in the laboratory focuses on IGF-1's regulation of nitric oxide synthase in the microvasculature and proximal tubules of the kidney as it relates to the regulation of GFR and tubular function in acute renal failure and diabetic nephropathy. The interplay of Angiotensin II and IGF-1 signaling pathways in these pathophysiological conditions are also investigated.

Funding

Commonwealth Health Research Board Grant: "Elucidating the Mechanism of IGF-1's Protective Role on Acute Renal Failure", 2006-2007

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