Professional Experiences

• Assistant Professor, Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, 2003-present
• Research Assistant Professor, Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, 2000-present
• Post-doctoral fellow, Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, 1998-2000

Education

• Ph.D., Cell and Molecular Biology, Institute of Biology and Pathology “Nicolae Simionescu”, Bucharest, Romania, 1997
• M.S., Biochemistry, Polytechnic Institute, Faculty of Chemistry, Bucharest, Romania, 1988

Publications (available in format; need help with PDF?)

Dobrian AD, Schriver SD, Khraibi AA, Prewitt RL. (2004) Pioglitazone prevents hypertension and reduces oxidative stress in diet-induced obesity. Hypertension. 43(1):48-56

Dobrian AD, Schriver SD, Lynch T, Prewitt RL. (2003) Effect of salt on hypertension and oxidative stress in a rat model of diet-induced obesity. Am J Physiol Renal Physiol. 285(4):F619-628

Prewitt RL, Rice DC, Dobrian AD. (2002) Adaptation of resistance arteries to increases in pressure. Microcirculation. 9(4):295-304. Review.

Khraibi AA, Solhaug MJ, Dobrian AD, Berndt TJ. (2002) Renal interstitial hydrostatic pressure and natriuretic responses to volume expansion in pregnant rats. Am J Physiol Renal Physiol. 282(5):F821-F825.

Rice DC, Dobrian AD, Schriver SD, Prewitt RL. (2002) Src autophosphorylation is an early event in pressure-mediated signaling pathways in isolated resistance arteries. Hypertension. 39(2 Pt 2):502-507.

Dobrian AD, Schriver SD, Prewitt RL. (2001) Role of angiotensin II and free radicals in blood pressure regulation in a rat model of renal hypertension. Hypertension. 38(3):361-366

Wesselman JP, Dobrian AD, Schriver SD, Prewitt RL. (2001) Src tyrosine kinases and extracellular signal-regulated kinase ½ mitogen-activated protein kinases mediate pressure-induced c-fos expression in cannulated rat mesenteric small arteries. Hypertension. 37(3):955-960

Dobrian AD, Davies MJ, Schriver SD, Lauterio TJ, Prewitt RL. (2001) Oxidative stress in a rat model of obesity-induced hypertension. Hypertension. 37(2 Part 2):554-560

Dobrian AD, Lazar V, Sinescu C, Mincu D, Simionescu M. (2000) Diabetic state induces lipid loading and altered expression and secretion of lipoprotein lipase in human monocyte-derived macrophages. Atherosclerosis. 153(1):191-201

Dobrian AD, Davies MJ, Prewitt RL, Lauterio TJ. (2000) Development of hypertension in a rat model of diet-induced obesity. Hypertension. 35(4):1009-1015

Parker SB, Dobrian AD, Wade SS, Prewitt RL. (2000) AT(1) receptor inhibition does not reduce arterial wall hypertrophy or PDGF-A expression in renal hypertension. Am J Physiol Heart Circ Physiol. 278(2):H613-H622

Dobrian A, Wade SS, Prewitt RL. (1999) PDGF-A expression correlates with blood pressure and remodeling in 1K1C hypertensive rat arteries. Am J Physiol. 276(6 Pt 2):H2159-H2167

Dobrian A, Lazar V, Tirziu D, Simionescu M. (1996) Increased macrophage uptake of irreversibly glycated albumin modified-low density lipoproteins of normal and diabetic subjects is mediated by non-saturable mechanisms. Biochim Biophys Acta. 1317(1):5-14

Dobrian A, Simionescu M. (1995) Irreversibly glycated albumin alters the physico-chemical characteristics of low density lipoproteins of normal and diabetic subjects. Biochim Biophys Acta. 1270(1):26-35

Tirziu D, Dobrian A, Tasca C, Simionescu M, Simionescu N. (1995) Intimal thickenings of human aorta contain modified reassembled lipoproteins. Atherosclerosis. 112(1):101-114.

Dobrian A, Mora R, Simionescu M, Simionescu N. (1993) In vitro formation of oxidatively-modified and reassembled human low-density lipoproteins: antioxidant effect of albumin. Biochim Biophys Acta. 1169(1):12-24.

Simionescu N, Sima A, Dobrian A, Tirziu D, Simionescu M.  (1993) Pathobiochemical changes of the arterial wall at the inception of atherosclerosis. Curr Top Pathol. 87:1-45. Review.

Research Interests & Funding

Research in my laboratory is focused on deciphering the cellular and molecular mechanisms involved in obesity-related hypertension.

We developed an animal model of diet-induced obesity and hypertension, which allows us to characterize the general renal and vascular mechanisms associated with development of hypertension in relation to obese state and to also investigate the effect of different dietary components/treatments on the renal and vascular function. In addition, in vitro studies on cultured renal epithelial cells will help us elucidate the role of intracellular redox state on the activity of the sodium transporters and the signaling pathways involved.

The ultimate goal of our studies is to better understand the key mechanisms associated with obesity hypertension and find new molecular targets for an efficient treatment.

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