Professional Experiences

• Professor, Pharmacology, Eastern Virginia Medical School, Norfolk, VA, 1986 - present
• Professor, Ophthalmology, Eastern Virginia Medical School, Norfolk, VA, 1999 - present
• Director, Thomas R. Lee Center for Ocular Pharmacology, Eastern Virginia Medical School, Norfolk, VA, 1999 - present
• Adjunct Associate Professor, Chemistry, Old Dominion University, Norfolk, VA, 1984 - present
• Associate Professor, Pharmacology, Eastern Virginia Medical School, Norfolk, VA, 1979 - 1986
• Assistant Professor, Pharmacology, Eastern Virginia Medical School, Norfolk, VA, 1972 - 1979
• Adjunct Assistant Professor, Chemistry, Old Dominion University, Norfolk, VA, 1976 - 1981
• Assistant Professor, Nursing and Dental Hygiene, Old Dominion University, Norfolk VA, 1972 - 1974
• Lecturer, School of Continuing Education, University of Virginia, 1972
• Teaching Assistant, Pharmacology, Medical College of Virginia, 1970 - 1971
• Assistant Instructor, Undergraduate Student Laboratory, Department of Botany, University of Michigan, 1967

Education

• Ph.D. Medical College of Virginia, Pharmacology, Health Sciences Division, Virginia Commonwealth University, Richmond, VA, 1972
• B.S. College of Pharmacy, University of Michigan, Ann Arbor, MI, 1968

Research Interests & Funding

The translation from preclinical data into advances in therapeutics has been a central theme in Dr. Williams' career. A classical education in pharmacy at the University of Michigan through a Ph.D. in Pharmacology at the Medical College of Virginia (now VCU) provided a solid foundation with the basic tools to build upon her early interests in how drugs worked and curiosity about factors affecting therapeutics from appropriate drug selection to patient compliance. She also is an invited speaker on issues regarding research integrity and has served as a consultant to the FDA and the NIH.

Her active, funded research programs center on identifying therapeutic potential from basic pharmacologic research. She is a founder of the Thomas R. Lee Center for Ocular Pharmacology. Chartered by the EVMS Board of Visitors, it is the fifth Center for Excellence at EVMS. Since its inception in 1998, the Center has attracted a substantial financial support and developed into a nationally recognized site. The Center today is a multi-disciplinary coalition of clinicians and basic scientists. The mission of the Center is discovery of new knowledge to benefit patients with blinding eye disease, especially those with glaucoma. The major initiative at the Center is the application of emerging technologies to the treatment of glaucoma. Other programs address ocular wound healing, biodefense, dry eye, amblyopia, and photodynamic therapy.

Prior to the funding of the TR Lee Center, she managed an active research program in cardiovascular pharmacology. Under her direction, notable advances were made in the effects of diabetes and of aging on collateral circulation.

Honors and Awards

• Nathaniel Kwit Distinguished Service Award, American College of Clinical Pharmacology(ACCP)
• Virginia Women in Medicine and Science Professional Achievement Award
• Dean's Faculty Achievement Award, EVMS
• Elected to Alpha Omega Alpha (AOA), medical honorary society
• Honoree Women in Bio, Washington, DC
• Holder of 5 patents
• American Heart Association Merit Award
• Sentara/Siemens Sponsored Researcher by American Heart Association/Virginia Affiliate
• Chief Academic Marshall, EVMS
• Research cited on 60 Minutes, a national TV news program
• Physicians for Responsible Research Award for development of patient oriented problem solving techniques
• American Heart Association/Virginia Affiliate Service Award

Memberships

• American Society for Pharmacology and Experimental Therapeutics (Nominating Committee, 1990-91, Educational Affairs Committee 1984-90). Executive Committee, Division of Pharmacology, 2001-present
• American College of Clinical Pharmacology (Fellow,1990, Regent, 1994-1999, Treasurer, 2000-2004, Chairman of Education Committee, 1994-1997)
• National Board of Medical Examiners (NBME), Comprehension Part 1 Multidisciplinary Task Force 1989-93, Standards Setting Committee 1991, Pharmacology Test Committee, 1994-1997
• Association for Research in Vision and Ophthalmology
• Southeastern Pharmacology Society
• American Heart Association - Basic Science Council, Circulation Council
• Association of Women in Science
• Association for Medical School Pharmacology Chairs

Manuscript and Journal Reviewing Activities

• Consultant to NIH Study Sections on Bioinformatics and on Risk, Prevention and Health Behavior, 1995-present
• Consultant to the FDA, 2000-2002
• NIHLBI, NIH, Cardiovascular and Renal Section, Extramural Reviewer, 1981-present
• American Heart Association, Virginia Affiliate Research Review Subcommittee 1981,1983, 1986-1990, Chairman 1988-1990
• NIH, Special Study Section Member, 1987, 1990, 1992
• Journal of Clinical Pharmacology, Editorial Board, 1994-present
• Journal of Pharmacology and Experimental Therapeutics, 1986-present
• Journal of Cardiovascular Pharmacology, 1983-present
• Annuals of Pharmacotherapy, 1988-present
• Investigation Ophthalmology and Visual Science, 1997-present

Publications

Sheppard JD Jr, Epstein RJ, Lattanzio FA Jr, Marcantonio D, Williams PB. (2006) Argon laser photodynamic therapy of human corneal neovascularization after intravenous administration of dihematoporphyrin ether. Am J Ophthalmol. 141(3):524-529

Williams PB, Sheppard JD Jr. (2005) Omalizumab: a future innovation for treatment of severe ocular allergy? Expert Opin Biol Ther. 5(12):1603-1609

Hosseini A, Lattanzio FA, Williams PB, Tibbs D, Samudre SS, Allen RC. (2006) Chronic topical administration of WIN-55-212-2 maintains a reduction in IOP in a rat glaucoma model without adverse effects. Exp Eye Res. 82(5):753-759

Lattanzio FA Jr, Crouch ER Jr, Mitrev PV, Williams PB, Allen RC. (2005) Cyclosporin as an adjunct to glaucoma filtration surgery. J Glaucoma. 14(6):441-447

Sheppard JD Jr, Lattanzio FA Jr, Williams PB, Mitrev PV, Allen RC. (2005) Confocal microscopy used as the definitive, early diagnostic method in Chandler syndrome. Cornea. 24(2):227-229

Samudre SS, Lattanzio FA Jr, Williams PB, Sheppard JD Jr. (2004) Comparison of topical steriods for acute anterior uveitis. J Ocul Pharmacol Ther. 20(6):533-547

Crouch ER Jr, Lattanzio FA Jr, Williams PB, Mitrev PV, Theobald T, Allen RC. (2004) Cyclosporin-augmented laser peripheral iridoplasty. Ophthalmic Surg Lasers Imaging. 35(6):475-481

Williams PB, Rice DC, Piepho RW, Lathers CM, Burckart GJ. (2002) Web-Based sharing of cutting-edge teaching strategies. Naunyn-Schmiedeberg's Arch Pharmacol. 366:90-95

Williams PB, Lathers CM, Smith CM, Payer A, Volle RL. (2001) Evaluation of student achievement and educational outcomes. J Clin Pharmacol. 41(12):1259-1270

Williams PB, Crouch ER Jr, Sheppard JD Jr, Lattanzio FA Jr, Parker TA, Mitrev PV. (2000) The birth of ocular pharmacology in the 20th century. J. Clin. Pharmacol. 40(9):990-1006

Rice DC, Williams P. (2000) Perspectives on Medical School Pharmacology. J Clin Pharmacol. 40:44-46

Wombolt DG, Jackson A, Punn R, Smith S, McCune TR, Williams PB. (1999) Case report: rhabdomyolysis induced by mibefradil in a patient treated with cyclosporine and simvastatin. J Clin Pharmacol. 39(3):310-312

Maroy B, Williams PB, Griffey PM. (1999) Electrocoagulation of benign adenoma of the papilla of vater: long-term follow-up of two patients without recurrence. Endoscopy. 31(9):S62-S63

Williams PB, Crouch ER Jr, Crouch ER, Mazaheri M. (1999) Topical Aminocaproic Acid facilitates reepitheliazation of persistent epithelial defects. Curr Eye Res. 18(2):150-157

Damji KF, Noel LP, Peterson RG, Ma PE, Clarke WN, Gilberg D, Crouch ER Jr, Williams PB. (1998) Topical versus intravenous administration of tranexamic acid: a comparison of intraocular and serum concentrations in the rabbit. Can J Ophthalmol. 33(6):308-313

Crouch ER III, Crouch ER Jr, Williams PB. (1998) Aminocaproic Acid and Tranexamic Acid Increase the Rate of Acute Corneal Reepithelialization in Sprague Dawley Rats. J. Ocular. Pharmacol. and Ther. 14:109-118

Kosko JR, Williams PB, Pratt MF. (1997) Correlation of neutrophil activation and skin flap survival in pharmacologically altered pigs. Ann Otol Rhinol Laryngol. 106(9):790-794

Crouch ER Jr, Williams PB, Gray M K, Crouch ER, Chames M. (1997) Topical Aminocaproic Acid in the Treatment of Traumatic Hyphema. Arch. Ophthalmol. 115:1106-1112

Pratt MF, Williams PB. (1996) Pentifoxifylline and acetylsalicylic acid in a pig random skin-flap model. J Otolaryngology. 25(6):393-398

Crouch ER Jr. Williams PB. Trauma: Ruptures and Bleeding. CD ROM of Clinical Ophthalmology, Harper & Row, New York, (1996)

Rangachari PK, Williams PB, Crankshaw DJ, Carpenter JR, Williams DW, Ebeigbe AB, Omogbai EKI. Providing Quality Education in Pharmacology: The Affordable Options. In: Pharmacological Sciences: Perspectives for Research in the Late 1990s, ed. by A.C. Cuello and B. Collier, Birkhauser Verlag, Basil (1995)

Layton CT, Williams PB, Hankins DB, Phan T, Key JH, Pratt MF. (1994) Pharmacological enhancement of random skin flap survival by prostaglandin E2. Arch Otolaryngol Head Neck Sur. 120(1):56-60

Williams PB, Hankins DB, Layton CT, Phan T, Pratt MF. (1994) Long-term pretreatment with pentoxifylline increases random skin flap survival. Arcah Otolaryngol Head Neck Surg. 120(1):65-71

Crouch ER, Williams PB. Trauma: Ruptures and Bleeding in Clinical Ophthalmology, Vol IV Chapter 61 p. 1-22. J.B. Lippincott, Philadelphia. Tasman, Wm. and Jaeger, E., editors (1993)

Crouch ER, Williams PB. (1992) Secondary hemorrhage in traumatic hyphema. Am J Ophthalmol. 113(3):344-346

Williams PB. (1991) Norepinephrine uptake and efflux from canine peripheral collateral arteries. J Cardiovasc Pharmacol. 18(2):198-206

Ehlers WH, Crouch ER Jr, Williams PB, Riggs PK. Factors affecting therapeutic concentration of topical aminocaproic acid in traumatic hyphema. Invest Ophthalmol Vis Sci. 1990;31(11):2389-2394

Burks TF, Williams PB, Duckles SP, Rosenfeld GC, Jones DJ. (1990) Promoting interest in Pharmacology through undergraduate research training. The Pharmacologist.  32:21-26

Williams PB. (1990) Incorporation of clinical pharmacology into the fourth year of the medical curriculum: teaching clinical pharmacology without a clinical pharmacologist. J Clin Pharmacol. 30(12):1065-1073

Burford HJ, Ingenito AJ, Williams PB. (1990) Development and evaluation of patient-oriented problem-solving materials in pharmacology. Acad Med. 65(11):689-693

Merritt JE, Williams PB. (1990) Vasospasm contributes to monosodium glutamate-induced headache. Headache. 30(9)575-580

Hardy TJ, Williams PB. (1988) Pre-eclampsia: A hypothesis for its etiology. Medical Hypotheses. 27:157-162

Williams PB, Rosenthal MD. (1988) Ascorbate increases apparent "specific" binding of [3H]pyrilamine to glass fiber filters. J Pharmacol Methods. 20(4):293-298

Allingham RR, Crouch ER Jr, Williams PB, Catlin JC, Loewy DM, Jacobson J. (1988( Topical aminocaproic acid significantly reduces the incidence of secondary hemorrhage in traumatic hyphema in the rabbit model. Arch Ophthalmol. 106(10):1436-1438

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