Editorial and Review Activities

• Editorial Board, Steroids, 2001-present
• Editorial Board, Biology of Reproduction, 2000-2004
• Peer reviewer, American Heart Association mid-Atlantic Research Consortium, 1997-2001
• Research Committee, American Heart Association: Virginia Affiliate, Chairman 1994-1996, member 1997-1999
• Research Allocation Review Committee for the American Heart Association: Virginia Affiliate, 1990-1993, Chairman, 1992-1993
• Member of Editorial Board of The Journal of Biological Chemistry, 1987-1993.
• Member of Editorial Board of American Journal of Physiology: Endocrinology and Metabolism, 1985-1992 and 1995-2001

Memberships

• American Society for Biochemistry and Molecular Biology (1982 to present)

Recent Publications

Blackmore PF. Progesterone metabolites rapidly stimulate calcium influx in human platelets by a src dependent pathway. Steroids. In press.

Zhang J. Blackmore PF. Hargrave BY. Xiao S. Beebe SJ. and Schoenbach KH.  Nanosecond pulse electric field (nanopulse): a novel non-ligand agonist for platelet activation. (2008) Archives of Biochemistry and Biophysics. 471: 240-248.

Schoenbach KH, Hargrave B, Joshi RP, Kolb JF, Osgood C, Nuccitelli R, Pakhomov A, Swanson J, Stacey M, White JA, Xiao S, Zhang J, Beebe SJ, Blackmore PF, Buescher ES. (2007) Bioelectric effects of nanosecond pulses. IEEE Transactions on Dielectrics and Electrical Insulators. 14:1088-1109

Dobrydneva Y, Weatherman RV, Trebley JP, Morrell MM, Fitzgerald MC, Fichandler CE, Chatterjie N, Blackmore PF. (2007) Tamoxifen stimulates calcium entry into human platelets. Journal of Cardiovascular Pharmacology. 50:380-390

Kolb JF, Kong MG, Blackmore PF. (2006) Special Issue on Nonthermal Medical/Biological Applications Using Ionized Gases and Electromagnetic Fields. IEEE Transactions on Plasma Science. 34:1250-1252

Frey W, White JA, Price RO, Blackmore PF, Joshi RP, Nuccitelli R, Beebe SJ, Schoenbach RH, Kob JF. (2006) Plasma membrane voltage changes during nanosecond pulsed electric field exposure. Biophysical J. 90:3609-15.

Holterman DA, Diaz JI, Blackmore PF, Davis JW, Schellhammer PF, Corica A, Semmes OJ, Blahou A. (2006) Overexpression of α-defensin is associated with bladder cancer invasiveness. Urol. Oncol. 24:97-108.

Dobrydneva Y, Abelt CJ, Dovel B,Thadigiri CM, Williams RL, Blackmore PF. (2006) 2-Aminoethoxydiphenyl borate as a prototype drug for a group of structurally related calcium channel blockers in human platelets. Molecular Pharmacology. 69:247-256

Frey W, White JA, Price RO, Blackmore PF, Joshi RP, Nuccitelli R, Beebe SJ, Schoenbach KH, Kolb JF. Plasma membrane voltage changes during nanosecond pulsed electric field exposure. Biophysical J. accepted for publication.

Hu Q, Viswanadham S, Joshi RP, Schoenbach KH, Beebe SJ, Blackmore PF. (2005) Simulations of transient membrane behavior in cells subjected to a high-intensity, ultra-short electric pulse. Physical Review E. 71:031914

Beebe SJ, Blackmore PF, Hall E, White JA, Willis LK, Fauntleroy L, Kolb JF, Schoenbach KH. (2005) Dynamic effects and applications for nanosecond pulsed electric fields in cells and tissues Proc. SPIE 5692:260-269, Advanced Biomedical and Clinical Diagnostic Systems III; Vo-Dinh T. Grundfest WS. Benaron DA. Cohn GE. Editors

Kolb JF, Frey W, White JA, Price RO, Blackmore PF, Beebe SJ, Joshi RP, Schoenbach KH. (2005) Real-time imaging of membrane potentials during exposure to nanosecond pulsed electric fields Proc. SPIE. 5692: 270-276, Advanced Biomedical and Clinical Diagnostic Systems III; Vo-Dinh T. Grundfest WS. Benaron DA. ohn GE. Editors

Zakharov SI, Smani T, Dobrydneva Y, Monje F, Fichandler C, Blackmore PF, Bolotina VM. (2004) Diethylstilbestrol (DES) is a potent inhibitor of CRAC channels and store-operated Ca²⁺ influx. Molecular Pharmacology. 66:702-707

White JA, Blackmore PF, Schoenbach KH, Beebe SJ. (2004) Stimulation of capacitative calcium entry in HL-60 cells by nanosecond pulsed electric fields (nsPEF). J.Biol. Chem. 279:22964-72

Schoenbach KH, Joshi RP, Kolb J, Chen N, Stacey M, Blackmore P, Buescher ES, Beebe, SJ. (2004) Ultrashort Electrical Pulses Open a New Gateway into Biological Cells. Proceedings of the IEEE. 92(7):1122-1137

Beebe SJ, Blackmore PF, White J, Joshi RP, Schoenbach KH. (2004) Nanosecond pulsed electric fields modulate cell function through intracellular signal transduction mechanisms. Physiological Measurement. 25: 1077-1093

Beebe SJ, White J, Blackmore PF, Deng Y, Somers K, Schoenbach KH. (2003) Diverse Effects of Nanosecond Pulsed Electric Fields on Cells and Tissues. DNA and cell biology. 22(12):785-796

Nemere I, Pietras RL, Blackmore PF. (2003) Membrane receptors for steroid hormones:  Signal transduction and physiological significance. Journal of Cellular Biochemistry 88(3):438-5

Dobrydneva Y, Williams RL, Katzenellenbogen JA, Ratz PH, Blackmore PF. (2003) Diethylstilbestrol and Tetrahydrochrysenes are calcium channel blockers in human platelets: relationship to the stilbene pharmacophore. Thrombosis Research. 110:23-31

Dobrydneva Y, Williams R, Morris GZ, Blackmore PF. (2002) Dietary phytoestrogens and their synthetic structural analogs as calcium channel blockers in human platelets. Journal of Cardiovascular Pharmacology. 40:399-410

Dobrydneva Y, Blackmore PF. (2001) 2-Amino-ethoxydiphenyl borate directly inhibits store-operated calcium entry channels in human platelets. Mol. Pharm. 60:541-552

Gwathmey T, Blackmore PF, Mahoney MC. (2002) Progesterone-induced calcium influx in Cynomolgus Monkey (Macaca fascicularis) spermatozoa. J. Andrology. 21:534-40

Ratz PH, McCammon KA, Altstatt D. Blackmore PF, Shenfeld OZ, Schlossberg SM. (1999) Rapid inhibition of bethanocol- and alpha,beta-methylene ATP- induced detrusor contractions by estradiol, progesterone and genistein. J. Urol. 162:1821-1828

Shenfeld OZ, McCammon KA, Blackmore PF, Ratz PH. (1999) Rapid effects of estrogen and progesterone on tone and spontaneous rhythmic contractions of the rabbit bladder. Urology Res. 27:386-392

Blackmore PF, Eisoldt S. (1999) The neoglycoprotein mannose-albumin, but not progesterone, activates T-type calcium channels in human sperm. Mol. Human Reprod. 5:101-109

Dobrydneva Y, Williams RL, Blackmore PF. (1999) trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br. J. Pharmacol. 128:149-157

Blackmore PF. (1999) Extragenomic actions of progesterone in human sperm and progesterone metabolites in human platelets. Steroids. 64:149-156

Blackmore PF. (1998) News and views of non-genomic progesterone receptors on spermatozoa. Andrologia. 30:255-261

Gresham J, Margiotta P, Palad A, Somers K, Blackmore  PF, Wright GL, Schellhammer P, Wasilenko W. (1998) Involvement of Shc in the signaling response of human prostate tumor cell lines to epidermal growth factor. Int. J. Cancer. 77:923-927

Glazier AT, Blackmore PF, Nolan RD, Wasilenko WJ. (1998) Attenuation of LPA-mediated calcium signaling and inositol polyphosphate production in rat-1 fibroblasts transformed by the v-src oncogene. Biochem Biophys Res Commun. 245:607-612

Nassar A, Mahoney M, Blackmore PF, Morshedi M, Ozgur K, Oehninger S. (1998) Alteration of intracellular calcium is not a causal mechanism for pentoxifylline-induced hyperactivated motility or acrosome reaction. Fertil Steril. 69:748-754

Wu Y, Palad AJ, Wasilenko WJ, Blackmore PF, Pincus WA, Schechter GL, Spoonster JR, Kohn, EC, Somers KD. (1997) Inhibition of head and neck squamous cell carcinoma growth and invasion by the calcium influx inhibitor, carboxyamido-triazole. Clinical Cancer Research. 3:1915-1921

Wasilenko WJ, Cooper J, Palad AJ, Somers, KD, Blackmore PF, Wright GL, Schellhammer PF. (1997) Calcium signaling in prostate cancer cells: evidence for multiple receptors and enhanced sensitivity to bombesin/GRP. Prostate. 30:167-173

Wasilenko WJ, Kohn EC, Palad AJ, Somers KD, Blackmore PF, Rhim JS, Wright GL, Schellhammer PF. (1996) Effects of the calcium influx inhibitor carboxyamido-triazole on the proliferation and invasiveness of human prostate tumor cell lines. Intl. J. Cancer. 68:259-264

Blackmore PF, Fisher JF, Spilman CH, Bleasdale JM. (1996) Unusual steroid specificity of the novel cell surface progesterone receptor on human sperm. Mol. Pharm. 49:727-739

Rzigalinski BA, Blackmore PF, Rosenthal MD. (1996) Arachidonate mobilization is coupled to depletion of intracellular calcium stores and influx of extracellular calcium in differentiated U937 cells. Biochem. Biophys. Acta. 1299:342-352

Alexander NJ, Kim HK, Blye RP, Blackmore PF. (1996) Steroid Specificity of the Human Sperm Progesterone Receptor. Steroids. 1996;61:116-125

Blackmore PF, Fisher JF, Spilman CH, Im WB, Bleasdale JH. (1995) Effects of Steroids on Calcium Fluxes in Human Sperm. in Human Acrosome Reaction. (eds P.Fenichel, J. Parinaud) Colloque INSERM/ John Libbey Eurotext Ltd. 236:165-177

Oehninger S, Blackmore PF, Mahony M, Hodgen G. (1995) Effects of hydrogen peroxide on human spermatozoa. J. Assisted Reprod and Genetics. 12:40-46

Rosenthal MD, Rzigalinski BA, Blackmore PF, Franson RC. (1995) Cellular regulation of arachidonate mobilization and metabolism. Prostaglandins Leukotrienes and Fatty Acids. 52:93-98

Morshedi M, Oehninger S, Blackmore PF, Bocca S, Coddington C, Hodgen GD. (1995) Investigation of some biochemical and functional effects of cryopreservation of human spermatozoa using an automated freezing-quick-thawing method. Int.J. of Andrology. 18:279-286

Kamada S, Blackmore PF, Kubota T, Oehninger S, Asada Y, Gordon K, Hodgen GD, Aso T. (1995) The role of endothelin-1 in regulating human granulosa cell proliferation and steroidogenesis in vitro. J. Clin. Endocrinol. and Metabolism 80:3708-3714

Blackmore PF, Im WB, Bleasdale JM. (1994) The cell surface progesterone receptor on human sperm is unlike the A ring reduced steroid site on the GABAA receptor/chloride channel. Mol. Cell Endocrinol. 104:237-243

Kamada S, Oehninger S, Mahony MC, Blackmore PF, Lanzendorf SE, Hodgen GD. (1994) Does endothelin - 1 affect human spermatozoa function? Am. J. Reprod Immunol. 31:91-98

Kamada S, Blackmore PF, Oehninger S, Gordon K, Hodgen GD. (1994) Existence of P2-purinoceptors on human and porcine granulosa cells. J. Clin. Endocrinol. and Metabolism. 78:650-656

Oehninger S, Blackmore P, Morshedi M, Sueldo C, Acosta AA, Alexander NJ. (1994) Defective calcium influx and acrosome reaction (spontaneous and progesterone-induced) in spermatozoa of infertile men with severe tetratozoospermia. Fertil Steril. 61:349-354

Blackmore PF. (1993) Rapid nongenomic actions of progesterone stimulate Ca2+ influx and the acrosome reaction in human sperm. Cellular Signalling. 5:531-538

Neulen J, Ishikawa K, Blackmore, PF, Beebe SJ. (1993) Identification and characterization of a novel progesterone binding protein in human semen. Endocrine J. 1:397-404

Blackmore PF, McPherson RK, Stevenson RW. (1993) Actions of a novel antidiabetic agent englitazone (CP 68,722) in rat hepatocytes. Metabolism. 42:1583-1587

Bocckino SB, Blackmore PF. (1993) Hepatic inositol phosphate and lipid messenger systems. In: Hepatic Transport and Bile Secretion: Physiology and Pathophysiology (N. Taroloni and P.D. Berk, eds.) Raven Press Ltd. New York, pp. 531-537

Blackmore PF. (1993) Thapsigargin elevates and potentiates the ability of progesterone to increase intracellular free calcium in human sperm. Cell Calcium. 14:53-60

Blackmore PF. (1992) Role of p21ras in hormone signaling and cell growth. Adv Exp Med Biol. 321:143-146

Blackmore PF, Oakes SG, Somers KD. (1992) Influence of K-ras transformation on H1-histamine signaling in Balb/3T3 cells. Oncogene. 7:2053-2057

Brucker C, Sandow BA, Blackmore PF, Lipford GB, Hodgen GD. (1992) Monoclonal antibody AG7 inhibits fertilization post sperm-zona binding. Molecular Reprod Development. 33:451-462

Oehninger S, Clark GF, Fulgham D, Blackmore PF, Mahony MC, Acosta AA, Hodgen GD. (1992) Specificity of the antagonistic effect of fucoidin on human sperm-zona pellucida interactions. J of Andrology. 13:519-525

Blackmore PF, Lattanzio FA. (1991) Localization of progesterone receptors on the head of human sperm. Biochem Biophys Res Commun. 181:331-336

Blackmore PF, Mojsov S, Exton JH, Habener JF. (1991) Absence of insulinotropic glucagon-like peptide - (7-37) receptors on isolated rat liver hepatocytes. FEBS Lett. 283:7-10

Blackmore PF, Neulen J, Lattanzio FA, Beebe SJ. (1991) Cell surface receptors for progesterone mediate calcium uptake in human sperm. J Biol Chem. 266:18655-18659

Mahony MC, Blackmore PF, Bronson RA, Alexander NJ. (1991) Inhibition of human zona pellucida tight binding in the presence of antisperm antibody positive polyclonal patient sera. J Reprod Immunol. 19:287-301

Mahony MC, Fulgham D, Blackmore PF, Alexander NJ. (1991) Elevation of human sperm-zona pellucida tight binding by presence of monoclonal antibodies to sperm antigens. J Reprod Immunol. 19:269-285

Ratz PH, Blackmore PF. (1990) Differential activation of rabbit femoral arteries by aluminum fluoride and sodium fluoride. J Pharmacol Exp Ther. 254:514-520

Kelley LL, Blackmore PF, Graber SE, Stewart SJ. (1990) Agents which raise cAMP in human T lymphocytes release an intracellular pool of calcium in the absence of inositol phosphate production. J Biol Chem. 265:17657-17664

Blackmore PF, Beebe SJ, Danforth DR, Alexander N. (1990) Progesterone and 17 alpha-hydroxyprogesterone. Novel stimulators of calcium influx in human sperm. J Biol Chem. 265:1376-1380

Augert G, Bocckino SB, Blackmore PF, Exton JH. (1989) Hormonal stimulation of diacylglycerol formation in hepatocytes. Evidence for phosphatidylcholine breakdown. J Biol Chem. 264:21689-21698

Blackmore PF, Augert G. (1989) Effect of hormones on cytosolic free calcium in adipocytes. Cell Calcium. 10:561-567

Lynch CJ, Blackmore PF, Johnson EH, Wange RL, Krone PK, Exton JH. (1989) Guanine nucleotide binding regulatory proteins and adenylate cyclase in livers of streptozotocin- and BB/Wor-diabetic rats. J Clin Invest. 83:2050-2062

Blackmore PF, Exton JH. (1989) Ca2+ fluxes and phosphoinositides in hepatocytes. Methods Enzymology. 173:534-545

Augert G, Blackmore PF, Exton JH. (1989) Changes in the concentration and fatty acid composition of phosphoinositides induced by hormones in hepatocytes. J. Biol Chem. 264:2574-2580

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