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 Woong-Ki Kim,
Ph.D.
Assistant Professor
Lewis Hall,
#3150
Office: (757) 446-5639
kimw@evms.edu
Teaching:
Biomedical Sciences Program Track: Molecular Integrative Biosciences (MIB)
Education
- B.S., Seoul
National University
- Ph.D.,
Rutgers University, Newark
-
Postdoctoral Training, Harvard Medical School
Research
Interests
The focus of my
research is on AIDS pathogenesis, neuroAIDS and the study of monocyte
maturation, infection and traffic. The goals of these studies are to define the
role of macrophages in the central nervous system, and monocytes and CD8+ T
lymphocytes outside the brain, contributing to pathogenesis of disease. Much of
this work is done in non-human primate models.
We have described target cells
infected in the CNS, their turnover and replacement by cells from the blood and
bone marrow, and emerging subpopulations of monocytes that expand with disease.
While investigating a pathogenic role of activated/infected monocytes in the
induction of brain infection and inflammation, we are currently working on
immunologic agents that selectively target SIV and HIV infected, activated
monocyte/macrophages. We use the CD8 lymphocyte depletion and rapid AIDS model
to study the consequences of monocyte/macrophage activation and traffic, the
role of viral sequences within SIV that may drive CNS disease.
Selected
Publications
- Wüthrich C,
Kesari S, Kim W-K, Williams K, Gelman R, Elmeric D, De Girolami U,
Joseph JT, Hedley-White T, Koralnik IJ (2006) Characterization of
lymphocytic infiltrates in progressive multifocal leukoencephalopathy:
Co-localization of CD8+ T cells with JCV-infected glial cells. J Neurovirol
12:116-128. Cover page of the journal.
- Kim W-K,
Alvarez X, Fisher J, Bronfin B, Westmoreland S, McLaurin J, Williams K
(2006) CD163 identifies perivascular macrophages in normal and viral
encephalitic brains and potential precursors to perivascular macrophages in
blood. Am J Pathol 168:822-834.
- Kim W-K,
Alvarez X, Williams K (2005) The role of monocytes and perivascular
macrophages in HIV and SIV neuropathogenesis: information from non-human
primate models. Neurotox Res 8:107-115.
- Williams K,
Westmoreland S, Greco J, Ratai E, Lentz M, Kim W-K, Fuller RA, Kim
JP, Autissier P, Sehgal PK, Schinazi R, Bischofberger N, Piatak M Jr, Lifson
JD, Masliah E, González RG (2005) Magnetic resonance spectroscopy reveals a
role of activated blood monocytes contributing to neuronal injury in simian
immunodeficiency virus neuroAIDS. J Clin Invest 115:2534-2545.
- Benito C,
Kim W-K, Chavarría I, Hillard CJ, Mackie K, Tolón RM, Williams K,
Romero J (2005) A glial endogenous cannabinoid system is up-regulated in the
brains of macaques with simian immunodeficiency virus-induced encephalitis.
J Neurosci 25:2530-2536.
- Kim W-K,
Corey S, Chesney G, Knight H, Klumpp S, Wüthrich C, Letvin NL, Koralnik IJ,
Lackner A, Veasey RS, Williams K (2004) Identification of T lymphocytes in
viral encephalitis: distribution of CD8+ T cells in association with CNS
vessels and virus. J Neurovirol 10:315-325.
- Kim W-K,
Corey S, Alvarez X, Williams K (2003) Monocyte/macrophage traffic in HIV and
SIV encephalitis. J Leukoc Biol 74:650-656. Cover page of the journal.
- Kim W-K,
Ganea D, Jonakait GM (2002) Inhibition of microglial CD40 expression by
pituitary adenylyl cyclase-activating polypeptide is mediated by
interleukin-10. J Neuroimmunol 126:16-24.
- Kim W-K,
Kan Y, Ganea D, Hart RP, Gozes I, Jonakait GM (2000) Vasoactive intestinal
peptide and pituitary adenylyl cyclase-activating polypeptide inhibit tumor
necrosis factor-a
production in injured spinal cord and in activated microglia via a cAMP-dependent
pathway. J Neurosci 20:3622-3630.
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