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EVMS Strelitz Diabetes Center Research: Swarup Chakrabarti, PhD Print E-mail
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Swarup Chakrabarti, PhD
Assistant Professor, Department of Internal Medicine

Dr. Chakrabarti received his post-doctoral training in diabetes in the Diabetes Center of Excellence at the University of Virginia. During that training, he studied beta cell transcription factors and epigenetic mechanism of insulin gene regulation. While he was at UVA, he started investigating the role of 12-lipoxygenaes in adipose tissue and beta cell dysfunction. Since joining EVMS in 2008, he has primarily been investigating the mechanisms underlying adipocyte dysfunction mediated by the activation of 12-lipoxygenase. His research also aims to understand the epigenetic mechanism of 12-lipoxygenase gene regulation.

Dr. Chakrabarti has presented his beta cell and adipocyte biology work in major professional meetings and has published key papers in peer-reviewed journals including Journal of Biological Chemistry and Obesity.

Selected Publications

  • Cole BK, Kuhn NS, Leone KA, Rabb RM, Nadler JL, Chakrabarti SK. 12/15-Lipoxygenase signaling inthe endoplasmic reticulum stress response. Endocrinology (under review).
  • Dobrian AD, Lieb DC, Cole BK, Taylor-Fishwick DA, Chakrabarti SK, Nadler JL. Functional and pathological roles of the 12- and 15-lipoxygenases. Prog Lipid Res, 2011 Jan;50(1):115-31. Epub 2010 Oct 21.
  • Chakrabarti SK, Wen Y, Dobrian AD, Cole BK, Ma Q, Pei H, Williams MD, Bevard MH, Vandenhoff GE, Keller SR, Gu J, Nadler JL. Evidence for Activation of Inflammatory Lipoxygenase Pathways in Visceral Adipose Tissue of Obese Zucker Rats. Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E175-87. Epub 2010 Oct 26.
  • Ma K, Nunemaker CS, Wu R, Chakrabarti SK, Taylor-Fishwick DA, Nadler JL. 12-Lipoxygenase products reduce insulin secretion and beta cell viability in human islets. J Clin Endocrinol Metab. 2010 Feb;95(2):887-93. Epub 2010 Jan 20.
  • Maier B, Ogihara T, Trace AP, Tersey SA, Robbins RD, Chakrabarti SK, Nunemaker CS, Stull ND, Taylor CA, Thompson JE, Dondero RS, Lewis EC, Dinarello CA, Nadler JL, Mirmira RG. The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice. J Clin Invest. 2010 Jun 1;120(6):2156-70. Epub 2010 May 24.
  • Dobrian AD, Lieb DC, Ma Q, Lindsay JW, Cole BK, Ma KW, Chakrabarti SK, Kuhn NS, Wohlgemuth SD, Fontana M, Nadler JL. Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects. Biochem Biophys Res Commun. 2010 Dec 17;403(3-4):485-90. Epub 2010 Nov 19.
  • Chakrabarti SK, Cole BK, Wen Y, Keller SR, Nadler JL. 12/15-Lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes. Obesity. 2009 Sept;17(9):1657-63. Epub 2009 June 11.
  • Babu DA, Chakrabarti SK, Garmey JC, Mirmira RG. PDX1 and BETA2/NEUROD1 participates in a transcriptional complex that mediates short-range DNA looping at the insulin gene. J Biol Chem. 2008 Mar 28;283(13):8164-72. Epub 2008 Feb 4.
  • Hagman DK, Latour MG, Chakrabarti SK, Fontes G, Amyot J, Tremblay C, Semache M, Lausier JA, Roskens V, Mirmira RG, Jetton TL, and Poitout V. Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene transcription and PDX-1 binding in islets. Diabetes. 2008 Feb;57(2):424-31. Epub 2007 Nov 8.
  • Wen Y, Gu J, Chakrabarti SK, Aylor K, Marshall J, Takahashi Y, Yoshimoto T, and Nadler JL. The role of 12/15-Lipoxygenase in the expression of IL-6 and TNF-alpha in macrophages. Endocrinology. 2007 Mar;148(3):1313-22. Epub 2006 Dec 14.

 
Last Updated on Friday, 13 May 2011 15:52