Professional Experiences

• Associate Professor, Departments of Physiological Sciences and Ophthalmology, Eastern Virginia Medical School, Norfolk, VA, 2008-present
• Basic Science Director, T.R. Lee Center for Ocular Pharmacology, 1999-present
• Adjunct Assistant Professor of Biomedical Sciences, Old Dominion University, Norfolk, VA, 1988-present
• Assistant Professor, Departments of Physiological Sciences and Ophthalmology, Eastern Virginia Medical School, Norfolk, VA, 1988-2008
• Research Assistant Professor, Department of Pharmacology, University of Nevada School of Medicine, Reno, NV, 1986-1988
• Research Fellow in Medicine and Physiology, University of Texas Health Science Center at Dallas, TX, 1984-1986

 Education

• Ph.D. Pharmacology, University of Miami, 1984
• M.S. Pharmacology, University of Miami, 1981
• B.S. Biology, University of Miami, Coral Gables FL, 1971

 Honors and Awards

• 2007, United States Patent 7388028 Methoxypolyethylene glycol thioester chelate and uses thereof (K. S.Schellenberg, J. Shaeffer, F.A. Lattanzio)
• 2003 & 2005, Invited: Gordon Conference on Glycobiology
• 2000, United States Patent 60020373 Chelate derivates as protectors against tissue injury (K.S.Shellenberg, J. Shaeffer, F.A. Lattanzio)
• 1991, Invited: Gordon Conference on Excitation-Contraction Coupling
• 1988, Eagles Award
• 1987, Sigma Xi
• 1986-1987, Bently Scholar
• 1984, Invited: Gordon Conference on Inotropic Agents
• 1984, Phi Kappa Phi Scholastic Honorary
• 1979, Invited: Gordon Conference on Transport Phenomena in Lipid Bilayers and Biological Membranes
• 1978, Invited: Frontiers of Biological Energetics, Philadelphia, PA

Memberships

• 1995-present, Association for Research in Vision and Ophthalmology (ARVO)
• 1986-present, Biophysical Society

Research Interests

Cardiovascular, cancer and ophthalmic pharmacology, including (1) the treatment of ischemia and reperfusion injury (2) novel neuroprotectants for the treatment of glaucoma and free radical scavengers for radiation- and chemo-protection during cancer therapy (3) the development of lacritin as a treatment for dry eye (4) anti-angiogenic compounds for the treatment of cancer and age related macular degeneration (5) the jellyfish Aurelia aurita as a model for ototoxicity and Parkinson's disease (6) use of optical probes and development of biomedical instruments, such as non-invasive, passive microwave devices to monitor brain temperature and telemetric intraocular pressure monitoring.

Selected Publications

Samudre S.S., Lattanzio F.A., Lossen V., Hosseini A., Sheppard J.D., McKown R.L., Laurie G.W., Williams P.B. Lacritin, a novel human tear glycoprotein, promotes sustained basal tearing and is well tolerated. Invest Ophthalmol Vis Sci. (2010) Nov 18. [Epub ahead of print]

Samudre S.S., Schneider J.L., Oltmanns M.H., Hosseini A., Pratap K., Loose-Thurman P., Allen R.C., Williams P.B., Lattanzio , F.A .Jr, Sheppard J.D. Jr. Comparison of topical and intravenous administration of WIN 55-212-2 in normotensive rabbits. Curr Eye Res (2008) 33:857-63.

Oltmanns M.H., Samudre S.S., Castillo I.G., Hosseini A., Lichtman A.H., Allen R.C., Lattanzio F.A, Jr.., Williams P.B. Topical WIN55212-2 alleviates intraocular hypertension in rats through a CB1 receptor-mediated mechanism of action. J Ocul Pharmacol Ther. (2008) 24:104-115. Jan 17 epub ahead of print.

Vilela M.J., Martins M.L., Renato N.S., Cazares L., Lattanzio F., Ward M. and Semmes O.J. Proteomic and fractal analysis of a phenotypic transition in the growth of human breast cells in culture. J.Statistical Mechanics (2007) P12006. Online at stacks.iop.org/JSTAT/2007/P12006.

Sutton-Smith M., Wong N.K., Khoo K.H., Wu S.W., Yu S.Y., Patankar M.S., Easton R., Lattanzio F.A., Morris H.R., Dell,  A. and Clark G. F. Analysis of protein-linked glycosylation in a sperm-somatic cell adhesion system. Glycobiology. (2007) 17:553-67. Epub 2007 Mar 2.

Markosyan N., Dozier B.L., Lattanzio F.A. and Duffy D.M. Primate granulosa cell response via prostaglandin E2 receptors increases late in the periovulatory interval. Biol Reprod. (2006) 75:868-76. Epub 2006 Aug 30.

Sheppard JD Jr, Epstein RJ, Lattanzio FA Jr, Marcantonio D, Williams PB. (2006) Argon laser photodynamic therapy of human corneal neovascularization after intravenous administration of dihematoporphyrin ether. Am J Ophthalmol. 141(3):524-529

Chalabi S, Panico M, Sutton-Smith M, Haslam SM, Patakar MS, Lattanzio FA. (2006) Differential O-Glycosylation of a Conserved Domain Expressed in Murine and Human ZP3. Biochemistry. 45(2):637-647

Lattanzio FA Jr, Tiangco D, Osgood C, Beebe S, Kerry J, Hargrave BY. (2005) Cocaine increases intracellular calcium and reactive oxygen species, depolarizes mitochondria, and activates genes associated with heart failure and remodeling. Cardiovasc Toxicol. 5(4):377-390

Hosseini A, Lattanzio FA, Williams PB, Tibbs D, Samudre SS, Allen RC. (2006) Chronic topical administration of WIN-55-212-2 maintains a reduction in IOP in a rat glaucoma model without adverse effects. Exp Eye Res. 82(5):753-759

Lattanzio FA Jr, Crouch ER Jr, Mitrev PV, Williams PB, Allen RC. (2005) Cyclosporin as an adjunct to glaucoma filtration surgery. J Glaucoma. 14(6):441-447

Tiangco DA, Lattanzio FA Jr, Osgood CJ, Beebe SJ, Kerry JA, Hargrave BY. (2005) 3,4-Methylenedioxymethamphetamine activates nuclear factor-kappaB, increases intracellular calcium, and modulates gene transcription in rat heart cells. Cardiovasc Toxicol. 5(3):301-310

Patankar MS, Jing Y, Morrison JC, Belisle JA, Lattanzio FA, Deng Y, Wong NK, Morris HR, Della A, Clark GF. (2005) Potent suppression of natural killer cell response mediated by the ovarian tumor marker CA125. Gynecol Oncol. 99(3):704-713

Lattanzio FA Jr, Sheppard JD Jr, Allen RC, Baynham S, Samuel P, Samudre S. (2005) Do injections of 5-fluorouracil after trabeculectomy have toxic effects on the anterior segment? J Ocul Pharmacol Ther. 21(3):223-235

Burch MG, Pepe GJ, Dobrian AD, Lattanzio FA Jr, Albrecht ED. (2005) Development of a coculture system and use of confocal laser fluorescent microscopy to study human microvascular endothelial cell and mural cell interaction. Microvasc Res. 70:43-52

Sheppard JD Jr, Lattanzio FA Jr, Williams PB, Mitrev PV, Allen RC. (2005) Confocal microscopy used as the definitive, early diagnostic method in Chandler syndrome. Cornea. 24(2):227-229

Samudre Ss, Lattanzio FA Jr, Williams PB, Sheppard JD Jr. (2004) Comparison of topical steroids for acute anterior uveitis. J Ocul Pharmacol Ther. 20(6):533-547

Crouch ER Jr, Lattanzio FA Jr, Williams PB, Mitrev PV, Thaeobald T, Allen RC. (2004) Cyclosporin-augmented laser peripheral iridoplasty. Ophthalmic Surg Lasers Imaging. 35(6):475-481

Hargrave BY, Tiangco DA, Lattanzio FA, Beebe SJ. (2003) Cocaine, not morphine, causes the generation of reactive oxygen species and activation of NF-kappaB in transiently cotransfected heart cells. Cardiovasc Toxicol. 3(2):141-151

Wong KN, Easton RL, Panico M, Sutton-Smith M, Morrison JC, Lattanzio FA, Morris HR, Clark GF, Dell A, Patankar MS. (2003) Characterization of the oligosaccharides associatd with the human ovarian tumor marker CA125. J Biol Chem. 278(31):28619-28634

Chalabi S, Easton RL, Patankar MS, Lattanzio FA, Morrison JC, Panico M, Morris HR, Dell A, Clark GF. (2002) The expression of free oligosaccharides in human seminal plasma. J Biol Chem. 277(36):32562-32570

Williams PB, Crouch ER Jr, Sheppard JD Jr, Lattanzio FA Jr, Parker TA, Mitrev PV. (2000) The birth of ocular pharmacology in the 20th century. J Clin Pharmacol. 40(9):990-1006

Easton RL, Patankar MS, Lattanzio FA, Leaven TH, Morris HR, Clark GF, Dell A. (2000) Structural analysis of murine zona pellucida glycans. Evidence for the expression of core 2-type O-glycans and the Sd(a) antigen. J Biol Chem. 275(11):7731-7742

Ratz PH, Lattanzio FA Jr, Salomonsky PM. (1995) Memory of arterial receptor activation involves reduced [Ca2+]i and desensitization of cross bridges to [Ca2+]i. Am J Physiol. 269:C1402-1407

Ratz PH, Callahan PE, Lattanzio FA Jr. (1993) Ketamine relaxes rabbit femoral arteries by reducing [Ca2+]i and phospholipase C activity. Eur J Pharmacol. 236(3):433-441

Ratz PH, Lattanzio FA. (1992) L-type Ca2+ channel desensitization by F- reduces the PhE- induced increase in [Ca2+]i but not stress. Am J Physiol. 262(31):C621-C627

Blackmore PF, Lattanzio FA. (1991) Cell surface localization of a novel nongenomic progesterone receptor on the head of human sperm. Biochem Biophys Res Commun. 181:331-336.

Blackmore PF, Neulen J, Lattanzio FA, Beebe SJ. (1991) Cell surface binding sites for progesterone mediate calcium uptake in human sperm. J Biol Chem. 266:18655- 18659

Gerthoffer WT, Murphey KA, Mangini J, Boman S, Lattanzio FA. (1991) Myosin phosphorylation and calcium in tonic and phasic contractions of colonic smooth muscle. Amer J Physiol. 260:G958-G964

Lattanzio FA, Bartschat DK. (1991) The effect of pH on rate constants ion selectivity and thermodynamic properties of fluorescent calcium and magnesium indicators. Biochem Biophys Res Comm. 177:184-191

Martinez-Zaguilan R, Martinez GM, Lattanzio FA, Gillies RJ. (1991) Simultaneous measurement of intracellular pH and calcium using the fluorescence of SNARFI and fura-2. Am J Physiol. 260:C297-307

Lattanzio FA. (1990) The effects of pH and temperature on fluorescent calcium indicators as determined with Chelex-100 and EDTA buffer systems. Biochem Biophys Res Commun. 171:102-108

Top