Professional Experiences

• Associate Professor, Physiological Sciences, 2007 - Present
• Assistant Professor, Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, 2001-2007
• Affiliate Assistant Scientist/Staff Scientist, Oregon National Primate Research Center/Oregon Health & Science University, Beaverton, OR, 1997-2001
• Postdoctoral Fellow, Oregon National Primate Research Center/Oregon Health & Science University, Beaverton, OR, 1992-1997

Education

• Ph.D., University of California San Francisco, CA, 1992
• B.A., Reed College, Portland, OR, 1984

Research Interests & Funding

Research in my laboratory focuses on the role of factors produced within the ovary that are essential for ovulation to occur. In the hours just before follicle rupture, the follicle destined to ovulate produces prostaglandins, which act within the follicle to stimulate ovulatory events. Our experiments examine how ovarian prostaglandins are made, where prostaglandins act within the follicle, and which important ovulatory events are triggered by prostaglandins.

By studying prostaglandins and other ovarian factors, we hope our research will lead to better treatments for infertility as well as the development of new contraceptive options.

Current and recent research support comes from NIH/NICHD, CICCR/CONRAD, the Commonwealth Health Research Board, and the Andrew W. Mellon Foundation

Recent Publications

Hester KE, Harper MJK, Duffy DM. (2010) Oral Administration of the Cyclooxygenase-2 (COX-2) Inhibitor Meloxicam Blocks Ovulation in Non-Human Primates When Administered to Simulate Emergency Contraception.  Human Reproduction 25:360-367.

Markosyan N, Duffy DM.  (2009) PGE2 acts via multiple receptors to regulate plasminogendependent proteolysis in the primate periovulatory follicle.  Endocrinology, 150:435-444.

Dozier BL, Watanabe K, Duffy DM. (2008) Two pathways for prostaglandin F2α  synthesis by the primate periovulatory follicle.  Reproduction, 136:53-63.

Stouffer RL, Xu F, Duffy DM. (2007) Molecular control of ovulation and luteinization in the primate follicle. Front Biosci. 12:297-307.

Yin H, Duffy DM, Gosden RG. (2006) Comparative maturation of cynomolgus monkey oocytes in vivo and in vitro. Reprod Biol Endocrinol., 4:14.

Cabrera RA, Dozier BL, Duffy DM. (2006) Prostaglandin endoperoxide synthase (PTGS1 and PTGS2) expression and prostaglandin production by normal monkey ovarian surface epithelium. Fertil Steril, 86:1088-96.

Markosyan N, Dozier BL, Lattanzio FA, Duffy DM. (2006) Primate granulosa cell response via prostaglandin E2 receptors increases late in the periovulatory interval. Biol Reprod. 75:868-76.

Duffy DM, Seachord CL, Dozier BL. (2005) An ovulatory gonadotropin stimulus increases cytosolic phospholipase A2 expression and activity in granulosa cells of primate periovulatory follicles. J Clin Endocrinol Metab. 90(10) :5858-5865

Duffy DM, Seachord CL, Dozier BL. (2005) Microsomal prostaglandin E synthase-1 (mPGES-1) is the primary form of PGES expressed by the primate periovulatory follicle. Hum Reprod. 20(6):1485-1492

Seachord CL, VandeVoort CA, Duffy DM. (2005) Adipose differentiation-related protein: a gonadotropin- and prostaglandi-regulated protein in primate periovulatory follicles. Biol Reprod. 72(6):1305-1314

Duffy DM, Dozier BL, Seachord CL. (2005) Prostaglandin dehydrogenase and prostaglandin levels in primate periovulatory follicles: Implications for control of primate ovulation by prostaglandin E2. J Clin Endocrinol Metab. 90(2):1021-1027

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