Glennan Center faculty and staff are actively involved in researching vaccines, osteoporosis, Alzheimer’s disease, infectious diseases, and endocrinology. Community volunteers of all ages are often needed to assist with the studies. Please contact the Geriatric Clinical Research Center at 446-7340 to learn more about how you can become a Glennan Center volunteer.

Active Research Studies

Study: Randomized, Double Blind, Placebo Controlled Phase II Trial of the Safety, Tolerability and Immunogenicity of Lyophilized Chimerivax™-Wn02 West Nile Vaccine In Healthy Adults

Objectives: This study is designed to assess safety, tolerability and immunogenicity of three dose levels of lyophilized ChimeriVax™-WN02 compared to placebo in healthy adults aged 18 to 40, then assess a single dose level against placebo in older healthy adults (≥ 41 years).

Recruitment: Open to enrollment subjects 65 year and older.

Study: A Preoperative and Post Operative Driving Study Concerning Patients with Total Knee and Hip Replacements: Postoperative Variation in Neurocognitive Status

Objectives: The purpose of this study is to determine the optimal post operative recovery time after a total hip or knee replacement surgery to resume driving.

Recruitment: Open to enrollment subjects.

Study: Response to Influenza: Aging and Vaccine Efficacy

Objectives: To examine the safety and immunogenicity of a vaccination strategies to enhance the Th1 response by booster at the peak of IS-Th1 expansion following first vaccination. The frequency of IS-Th1 and the antibody level on days 7 and 28 will be used as the two main indicators of immunogenicity, although CD8+ T cell response will also be analyzed. The safety profile to be assessed includes immediate adverse events, solicited local and systemic events, and unsolicited adverse events.

Recruitment: Enrollment on hold.

Study: A Phase IV Clinical Trial to Evaluate the Safety and Tolerability of Zostavax™ in Subjects >/=60 Years of Age

Objectives: The purpose of the study is to accumulate additional safety data on the administration of ZOSTAVAX ™ in subjects 60 years and older. The study will evaluate the general safety of ZOSTAVAX™ in subjects 60 years of age and older by evaluating the relative risk of developing serious clinical adverse experiences for 42 days and 6 months post-vaccination in subjects who receive the vaccine and those who receive placebo.

Recruitment: Enrollment open.

Study: Transfusion Therapy Trial for Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair (FOCUS)

Objectives: The purpose of the study is to compare the effect of symptomatic transfusion to 10g/dL threshold transfusion on: Ability to walk 10 feet (or across a room) without human assistance 60 days after study entry; unstable angina, myocardial infarction in-hospital or death within 30 days; other outcomes including mortality, morbidity, and functional recovery.

Recruitment: Enrollment open to subjects at Sentara Norfolk General Hospital and DePaul Medical Center for people over the age of 50.

Student/Resident Research

Opportunities exist for students and residents to fulfill their program research requirements using Glennan Center faculty as mentors.

• Residency Program
• Geriatric and Gerontologic Elective

For more information contact:

For more
information or to volunteer for a study, contact:

Geriatric Clinical Research Center
(757) 446-7340

Madeline Dunstan
Phone: (757) 446-7436
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