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Margaret J. Wortman, Ph.D. Print E-mail
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Wortman_MargaretResearch Assistant Professor

Lewis Hall, #3144
Office: (757) 446-5953
Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Biomedical Sciences Program Track: Molecular Integrative Biosciences (MIB)

Education

  • B.A., MacMurray College, Jacksonville, IL
  • M.S., University of Florida, Gainesville, FL
  • Ph.D., New York University, New York, NY
  • Postdoctoral Training, The Rockefeller University and Mount Sinai School of Medicine, New York, NY

Selected Publications

  • Wortman, M.J., Johnson, E.M., and Bergemann, A.D. Mechanism of DNA binding and localized strand separation by Puralpha and comparison with Pur family member, Purbeta, BBA Mol. Cell Res. Accepted Aug. 20, 2004, Available online Sept. 27, 2004.
  • Daniel, D.C., Wortman, M.J., Schiller, R.J., Liu, H., Gan, L.. Mellen, J.S., Chang, C.F., Gallia, G.L., Rappaport, J., Khalili, K., and Johnson, E.M. Coordinate effects of human immunodeficiency virus type 1 protein Tat and cellular protein Puralpha on DNA replication initiated at the JC virus origin. J. Gen Virol. 2001. 82(Pt 7):1543-53.
  • Wortman, M.J., Krachmarov, C.P., Kim, J.H., Gordon, R.G., Chepenik, L.G., Brady, J.N., Gallia, G.L., Khalili, K., and Johnson, E.M. Interaction of HIV-1 Tat with Puralpha in nuclei of human glial cells: characterization of RNA-mediated protein-protein binding. J. Cell Biochem. 2000.77(1):65-74.
  • Gallia, G.L., Darbinian, N., Tretiakova, A., Ansari, S.A., Rappaport, J., Brady, J., Wortman, M.J., Johnson, E.M., and Khalili, K. Association of HIV-1 Tat with the cellular protein, Puralpha, is mediated by RNA. Proc. Natl. Acad. Sci. USA. 1999. 96(20):11572-7.
  • Itoh, H., Wortman, M.J., Kanovsky, M., Uson, R.R., Gordon, R.E,, Alfano, N., and Johnson, E.M. Alterations in Pur(alpha) levels and intracellular localization in the CV-1 cell cycle. Cell Growth Differ. 1998.9(8):651-65.
  • Solomon, J.J., Cote, I., L, Wortman, M., Decker, K., and Segal, A. In vitro alkylation of calf thymus DNA by acrylonitrile. Isolation of cyanoethyl-adducts of guanine and thymine and carboxyethyl-adducts of adenine and cytosine. Chem Biol Interact. 1984. 51(2):167-90.
  • Wortman, M.J., and Segal, A. The isolation and purification of mouse epidermal nuclei. Anal. Biochem. 1981. 115(1):147-50.
  • Segal, A., Mate, U., and Wortman, M. Phosphate diester formation following reaction of beta-propiolactone with thymidine-5'-monophosphoric acid. Chem. Biol. Interact. 1978.21(2-3):249-61.

 

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Last Updated on Friday, 02 September 2011 09:50