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Julius O. Nyalwidhe, Ph.D. Print E-mail
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Nyalwidhe_JuliusAssistant Professor

Lewis Hall, #3011
Office: (757) 446-5682
Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Teaching
Biomedical Sciences Program Track: Molecular Integrative Biosciences (MIB)

Education

  • B.S., Kenyatta University, Kenya
  • M.S., University of Nairobi, Kenya
  • Ph.D., Philipps University, Marburg, Germany
  • Postdoctoral Training, Philipps University, Marburg, Germany

Research Interests

Dr. Nyalwidhe is interested in the application of functional, expressional and structural proteomics approaches to the study of human diseases with emphasis on infectious diseases and cancer. This includes research on human malaria caused by Plasmodium falciparum, a variety of other infectious agents, prostate cancer and viral-induced carcinomas, in addition to other forms of cancer.

The focus is on the mechanisms of interaction between infectious pathogens and their host cells, the mechanism of metastasis in cancer and the analysis of the proteome of human body fluids to identify clinically useful biomarkers for the diagnosis and prognosis of disease. Dr. Nyalwidhe is also using molecular biology and different mass spectrometry techniques in analyzing, monitoring and quantifying post-translational modifications in proteins to determine their influence in the progression and outcome of disease.

Selected Publications

  • Belgnaoui, MS, Nyalwidhe, JO., Guo X and Semmes OJ (2010). The viral oncoprotein Tax sequesters DNA-damage response factors by tethering MDC1 to chromatin.  J Biol Chem. 2010 Aug 20. [Epub  ahead of print]
  • Gronemus, JQ, Hair, PS, Crawford, KB., Nyalwidhe, JO, Cunnion, KM, Krishna, NK (2010) Potent inhibition of the classical pathway of complement by a novel C1q-binding peptide derived from the human astrovirus coat protein. Molecular Immunology 2010 Aug 20. [Epub ahead of print]
  • Guo X, Ward MD, Teidebohl JB, Oden YM, Nyalwidhe, JO and Semmes OJ. (2010)
  • Interdependent phosphorylation within the kinase domain T-loop regulates CHK2 activity. J Biol Chem.  2010 Aug 16. [Epub ahead of print]
  • Azimzadeh O., Sow, C., Geze, M., Nyalwidhe JO, and Florent I. (2010) Plasmodium falciparum PfA-M1 aminopeptidase is trafficked via the parasitophorous vacuole and marginally delivered to the food vacuole. Malaria Journal 2010, 9:189 doi:10.1186/1475-2875-9-189.
  • Drake RR., Elschenbroich S., Lopez-Perez, O., Kim, Y., Ignatchenko, V., Ignatchenko, A., Nyalwidhe, JO., Basu, G., Wilkins, CE., Gjurich, B., Lance, RS., Semmes,  OJ.,  Medin, JA.  and Kislinger, T. (2010) In-depth proteomic analyses of direct expressed prostatic secretions. Journal of Proteome Research, 9: 2109-16.
  • Hansmeier, N., Chao Tzu-Chiao., Nyalwidhe JO, and Kalinowski, J (2009)  Comprehensive proteome profiling of the Fe(III)-reducing myxobacterium Anaeromyxobacter dehalogenans 2CP-C during growth with fumarate and ferric citrate. Proteomics, 10:1673-84.
  • Britten RA., Mitchell S., Johnson AM., Singletary SJ., Keeney, SK., Nyalwidhe, JO., Karbassi ID, Lonart G., Sanford, LD., and Drake RR. (2010). The identification of serum biomarkers of high LET radiation exposure and biological sequelae.  Journal of Health Physics, 98 (2) 196-203.
  • Cazares, L.H., Troyer, D.A., Mendrinos, S., Lance, R.S., Nyalwidhe, JO., Beydoun H, Clements, M.A., Drake, R.R. and Semmes, O.J. (2009) Imaging mass spectrometry of a specific fragment of MEKK2 discriminates cancer from uninvolved prostate tissue. Clin. Cancer Res. 15: 5541-51.
  • Karbassi ID, Nyalwidhe, JO, Wilkins CE, Cazares L, Lance RS, Semmes J, and Drake R (2009). Proteomic expression profiling and identification of serum proteins using immobilized trypsin beads with MALDI-TOF/TOF. Journal of Proteome Research, 8:4182-92.
  • Drake RR, White KY, Fuller TW, Igwe E, Clements MA, Nyalwidhe JO, Given RW, Lance RS, and Semmes OJ. (2009) Clinical collection and protein properties of expressed prostatic secretions as a source for biomarkers of prostatic disease.  Journal of Proteomics 72, 907-17.
  • Schaub, N.P., Jones, K., Nyalwidhe, JO., Cazares, L.H., Karbassi, I.D., Semmes, O.J., Feliberti, E., Perry, R.R. and Drake, R.R. (2009) Serum proteomic biomarker discovery reflective of stage and  obesity in breast cancer patients. J. Am. Coll. Surg., 208:970-8.
  • White KY, Rodemich L, Nyalwidhe JO, Communale MA, Clements MA, Lance RS, Schellhammer PF, Mehta A, Semmes OJ, and Drake RR. (2009). Glycomic characterization of prostate specific antigen and prostatic acid phosphatase in prostate cancer and benign disease seminal plasma fluids. Journal of Proteome Research 8, 620–630.
  • Azim-Zadeh O, Hillebrecht A, Linne U, Marahiel MA, Klebe G, Lingelbach K, and  Nyalwidhe J. (2007). Use of biotin derivatives to probe conformational changes in proteins. J Biol Chem. 282:  21609 – 21617.
  • Shamseldin A, Nyalwidhe J, and Werner D. (2006). A proteomic approach towards the analysis of salt tolerance in Rhizobium etli and Sinorhizobium meliloti strains. Current Microbiology. 52:333-339.
  • Nyalwidhe J, and Lingelbach K (2006). Proteases and Chaperones are the most abundant proteins in the parasitophorous vacuole of Plasmodium falciparum – infected erythrocytes. Proteomics. 5:1563-73.
  • Baumeister S, Endermann T, Charpian S, Nyalwidhe J, Duranton C, Huber S, Kirk K, Lang F, and Lingelbach K (2003). A biotin derivative blocks parasite induced novel permeation pathways in Plasmodium falciparum - infected erythrocytes. Mol Biochem Parasitol. 132:35-45.
  • Nyalwidhe J, Maier U-G, and Lingelbach K (2003).Intracellular parasitism: cell biological adaptations of parasitic protozoa to a life inside cells. Zoology 106: 341-48.
  • Nyalwidhe J, Baumeister S, Hibbs AR, Tawill S, Papakrivos J, Volker U, and Lingelbach K (2002). A nonpermeant biotin derivative gains access to the parasitophorous vacuole in Plasmodium falciparum-infected erythrocytes permeabilized with streptolysin O.J Biol Chem. 277: 40005-11.Khan B, Omar S, Kanyara JN, Warren-Perry M, Nyalwidhe J, Peterson DS, Wellems T,  Kaniaru S, Gitonga J, Mulaa FJ, and Koech DK. (1997). Antifolate drug resistance and point mutations in Plasmodium falciparum in Kenya. Trans of the Royal Soc of Trop Med and Hyg, 91, 456-460.

 

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Last Updated on Friday, 02 September 2011 09:54