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Ann E. Campbell, Ph.D. Print E-mail
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Campbell_Ann Professor

Lewis Hall, #3166
Office: (757) 446-5667
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Teaching: Virology and Immunology

Biomedical Sciences Program Track: Molecular Integrative Biosciences (MIB)

Education

  • B.S., University of Maryland
  • M.S., Ph.D., Medical College of Virginia
  • Postdoctoral Training, Pennsylvania State University College of Medicine

Research Interests

Dr. Campbell's laboratory pursues studies on the pathogenesis of the herpesvirus, cytomegalovirus (CMV). This virus causes severe complications in infected newborns, AIDS patients and immunosuppressed bone marrow or organ transplant recipients. Acute and latent infections occur in a variety of organs and cell types within the host.

One prominent cell type infected during both acute and latent stages of infection is the macrophage. This laboratory has identified a gene region of murine CMV (MCMV) that is required for efficient infection of macrophages and hence infectivity in vivo. Deletion of three genes within this region results in a mutant virus that replicates poorly in macrophages in vitro and in mice. The product of these three genes has been characterized, and they form a stable complex in infected cells. By using a combination of genetic manipulations, molecular biology, proteomics, and in vivo studies, the laboratory pursues studies to characterize the structure of this complex and to decipher the function of these viral proteins in regulating cell tropism.

A second project aims to identify the immune response to MCMV in the salivary gland, a site of viral persistence. Assessment of the phenotype and cytokine/chemokine profiles of cells infiltrating in response to MCMV infection has identified populations of cells unique to this mucosal site. Continued studies aim to identify the function of the site-specific cells in controlling infection.

Selected Publications

  • Hanson, L.K., J.S. Slater, Z. Karabekian, G. Ciocco-Schmitt, and A.E. Campbell. 2001. Products of US22 gene M140 and M141 confer efficient replication of murine cytomegalovirus in macrophages and spleen. J. Virol. 75(14):6292-6302.
  • Hanson, L.K., J.S. Slater, Z. Karabekian, G. Ciocco-Schmitt, and A.E. Campbell. 2001. Products of US22 gene M140 and M141 confer efficient replication of murine cytomegalovirus in macrophages and spleen. J. Virol. 75(14):6292-6302.
  • Cavanaugh, V.J., Y. Deng, M. Birkenbach, J.S. Slater and A.E. Campbell. 2002. Vigorous innate and virus-specific CTL responses to murine cytomegalovirus in the submaxillary salivary gland. J. Virol. 77:1703-1717.
  • Arase, H., E.S. Mocarski, A.E. Campbell, A.B. Hill, and L.L. Lanier. 2002. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science 296: 1323-1326.
  • Cavanaugh, V.J., Y. Deng, M. Birkenbach, J.S. Slater and A.E. Campbell. 2002. Vigorous innate and virus-specific CTL responses to murine cytomegalovirus in the submaxillary salivary gland. J. Virol. 77:1703-1717.
  • Menard, C., M. Wagner, Z. Ruszics, K. Holak, W. Brune, A.E. Campbell, and U.H. Koszinowski. 2003. Role of murine cytomegalovirus US22 gene family members for replication in macrophages. J. Virol. 77:5557-5570.
  • Karabekian, Z., L.K. Hanson, J.S. Slater, N.K. Krishna, L.L. Bolin, J.A. Kerry, and A.E. Campbell. 2005. Complex formation among murine cytomegalovirus US22 proteins encoded by genes M139, M140, and M141. J. Virol. 79:3525-3535.
  • Hanson, L.K., L.F. Cageao, R.E. Brock, J.S. Slater, B.L. Dalton, J.A. Kerry, and A.E. Campbell. 2005. Characterization and regulation of essential murine cytomegalovirus genes m142 and m143. Virology 334:166-177.
  • Cavanaugh, V.J., D.H. Raulet, and A.E. Campbell. 2007. Up-regulation of CD94/NKG2A receptors and Qa-1b ligand during murine cytomegalovirus infection of the salivary gland. J. Gen. Virol. 88:1440-1445.
  • Campbell, A.E. and V.J. Cavanaugh. 2008. The salivary glands as a privileged site of cytomegalovirus immune evasion and persistence. Medical Microbiol. and Immunol. 197:205-213.
  • Laura K. Hanson, Jacquelyn S. Slater, Victoria J. Cavanaugh, William W. Newcomb, Lisa Bolin, Christine N. Nelson, Lisa D. Fetters, Qiyi Tang, Jay C. Brown, Gerd G. Maul and Ann E. Campbell. 2009. Murine Cytomegalovirus Capsid Assembly Is Dependent on US22 Family Gene M140 in Infected Macrophages. J.Virol. 83(15):7449-7456.

 

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Last Updated on Thursday, 01 September 2011 15:24