Biomedical Sciences, PhD Program Course Descriptions
Biomedical Sciences (BP) Course Descriptions – EVMS 2015-2016
(*) - denotes elective course
BP700. Cell Structure and Function. 4 credits. The course provides a foundation in cellular and molecular biology, including cell structure, DNA and RNA structure and function, protein synthesis, and regulation of gene expression.
BP703 or 803. Integrated Metabolism and Nutrition. 4 credits. Prerequisite: BP702/802. Biochemistry of carbohydrates, glycolysis, citric acid cycle, oxidative phosphorylation, lipids, nitrogen metabolism, heme metabolism, iron, calcium, vitamins, and nutrition.
BP708 or 808. Medical Neuroscience*. 5 credits. Lecture and laboratory; Survey course in neuroscience. Basic structure and function of the nervous system is covered with clinical emphasis on problem solving and lesion localization.
BP 709 or 809. Medical Microbiology – Bacteriology*. 2 credits. Introduction to bacteria, including their structure, growth, genetics, and pathogenesis; the mechanism of action of antimicrobial drugs and the fundamentals of prevention of disease. Specific bacterial pathogens and the diseases they cause are discussed in detail. A section of the Medical Microbiology course.
BP710 or 810. Medical Microbiology – Virology*. 2 credits. Virology will emphasize basic concepts such as morphology, structure, growth and pathogenesis. A discussion of selected medically important pathogens and the diseases they cause will follow. A section of the Medical Microbiology course.
BP717 or 817. Research Techniques. 2 credits. Lectures covering topics in molecular cloning and analysis, detection systems including PCR and real time PCR, working with proteins, basics of cell culture.
BP718 or 818. Introduction to the Laboratory. 2 credits. Intensive laboratory course introducing students to basic research techniques, including DNA purification, subcloning, polymerase chain reaction, and cell culture methods.
BP719 or 819; 720 or 820; 721 or 821. Biomedical Sciences Lab Rotation I, II, III. 2 credits each. Laboratory rotations with a pre-designated faculty member in which the student obtains hands-on experience. Designed for students to sample different types of research models, techniques, and subject matter.
BP722 or 822. Bioinformatics. 1 credit. Introduction tobasic concepts in bioinformatics. Use of Incogen and Vector NTI software and tools on the NCBI website. Lecture and computer laboratory will cover topics such as DNA analysis tools, PCR primer design, motif analysis, similarity searches, restriction enzyme analysis, multiple sequence alignments, protein sequence identification, phylogenetic tools and public databases.
. *. credit. Laboratory course providing hands-on introduction to microarray technology, including experimental design, slide spotting, sample labeling, hybridization and data analysis.
. *. 1 credit. Laboratory course: introduction to proteomic techniques, including 2D-gel electrophoresis and mass spectrometry.
BP732 or 832. Biomedical Sciences Seminar (Journal Club). 1 credit. Pass/fail grading only. Seminar presentations by students in various research areas: e.g., tumor biology, infectious diseases, immunology, molecular cell biology, cardiovascular and reproductive physiology, endocrinology and neuroscience. Journal articles describing major scientific advances are discussed and critiqued. (Offered fall and spring each year)
BP741 or 841. Introduction to the Research Literature. 1 credit. Designed to train students in the interpretation of research literature. Students will assess the introduction, methods, results and discussion sections of journal articles.
BP734 or 834. Concepts in Research Design. 3 credits. Students will learn how to design and write a realistic research proposal and a will gain a general understanding of how different techniques can be used to address a wide range of research questions. Students will gain experience in small group presentation, evaluation and discussion of current scientific literature.
BP748 or 848. Advanced Cell Biology. 1 credit. Prerequisite: BP 702 or 802. Topics in contemporary cell and molecular biology, including the molecular genetic basis of normal and aberrant cell growth, transcription, translation, signal transduction, oncogenes, and growth factors.
BP761 or 861. Essentials of Physiology. 3 credits. A comprehensive introduction to integrative organ system physiology and homeostatic regulatory mechanisms. Interrelationships of structure and function are reinforced. Review of classical research papers in physiology by students is required.
BP762 or 862. Advanced Molecular and Cellular Techniques*. 3 credits. Methods of gene manipulation and mutagenesis, and immunological techniques. Topics include deletion and site directed mutagenesis, chimeras, use of linkers and expression tags, SDS polyacrylamide gel electrophoresis, in vitro transcription and translation, cell culture, transfection and methods of protein analysis.
BP765 or 865. Introduction to Drug Discovery. 1 credit. Theory of drug action, molecular modeling in drug design, preclinical research and development process and clinical trials and regulation of drugs. The course ends with a project in which groups of students design a new drug for a specific target.
BP766 or 866. Inflammation, Cancer and Metabolism. 3 credits. Molecular and cellular bases of inflammation and immunity; elements of tumor biology and cardiovascular and metabolic function and dysfunction. Integrative topics link inflammation with pathogenesis of cancer and cardio-metabolic diseases.
BP773 or 873. Responsible Conduct in Science. 1 credit. Series of lectures exposing graduate students to moral and ethical dilemmas in biomedical sciences. The course will also expose students to peer review processes related to submission of grants and manuscripts.
BP776 or 876. The Mammalian Ovary*. 3 credits. Examination of the formation and cyclical changes within the mammalian ovary, with emphasis on the endocrine and paracrine factors which regulate adult ovarian function.
BP777 or 877. Endocrine and Reproductive Physiology*. 2 credits. Basic principles of endocrinology and reproduction, including hormones, receptors, and feedback regulation. Covers major organs and their function in humans, as well as special topics of current clinical interest. A section of the Medical Physiology course.
BP895. Special Topics in Biomedical Sciences*. 1-3 credits. Guided readings and discussions of current research topics in a specialized area. Prerequisites: approval of instructor.
BP898. Research. 1-9 credits. Laboratory research leading to preparation of a Ph.D. dissertation.
BP899. Dissertation. 1-9 credits. Review of the literature, written presentation of Ph.D. student’s research as the Ph.D. dissertation.