Faculty

The high incidence of human neonatal morbidity and mortality associated with low birth weight and prematurity as well as impact of the ever increasing exposure of humans to environmental endocrine disruptors indicates need for more intensive study of the mechanisms underlying the development of the primate placenta and fetus.  Read more...

Dr. Pepe came to EVMS in 1978 as an Associate Professor in the Department of Physiology.  He was named Professor and Chair in in 1985 and served in that position until 2005.  He also served as Associate Dean of Research from 1995 to 1997.  He was appointed Dean and Provost from 2004-2012.  He returned as Chair to the Department of Physiological Sciences in 2011 where he continues to teach and perform research.

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Pediatric nephrology

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Co-Course Director, EVMS Biomedical Masters Program, Fall 2012 - present

Course Director, Pharmacology, EVMS Department of Physiological Sciences, Fall 2007 - Spring 2012

Professor, EVMS Department of Physiological Sciences, 1997-present

Adjunct Associate Professor, Biomedical Sciences, Old Dominion University, 1989-present

Associate Investigator, Howard Hughes Medical Institute, 1980-1988

Assistant Professor, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, 1978-1988

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Frank J. Castora, PhD - Research Interests

Course Director, EVMS Biochemistry/Integrated Metabolism and Nutrition, 2010-present

Professor, EVMS Department of Physiological Sciences, 2010-present

Adjunct Associate Professor, EVMS Department of Neurology, 1996-present

Adjunct Associate Professor, Department of Biological Sciences, Old Dominion University, 1989-present

Associate Professor, EVMS Department of Physiological Sciences, 1999-2010

Associate Professor, EVMS Department of Biochemistry, 1988-1999

Assistant Professor, Chemistry Department, University of Maryland Baltimore County, 1981-1988

Research Lecturer in Biochemistry, Biochemistry Department, SUNY at Stony Brook, 1980-1981

National Research Service Award Fellow, Biochemistry Department, SUNY at Stony Brook, 1980-1981

Postdoctoral Research Associate, Biochemistry Department, SUNY at Stony Brook, 1976-1980

Lecturer, Chemistry Department, Rutgers University, 1975-1976

Charles and Johanna Busch Fellow, Chemistry Department, Rutgers University, 1973-1975

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Obesity is a growing epidemic and the health costs and morbidities associated with the disease are substantial and projected to increase in the next decades worldwide.

My lab is interested in mechanisms leading to cardiovascular complications of obesity. In particular the research is focused on how inflammation and lipotoxicity in adipose tissue leads to insulin resistance and type2 diabetes. I am also interested in renal mechanisms that contribute to hypertension in obesity.

To read more, click on:  Anca Dobrian, PhD - Research Interests

Faculty

• Platelet signal transduction
• Regulation of store-operated calcium channels
• Phytoestrogens and non-steroidal estrogens as calcium channel modulators
• Anti-thrombotic actions of dietary phytoestrogens and polyphenols

FUNDING AND RESEARCH SUPPORT:

 American Heart Association, National Affiliate Scientist Development Grant
“Regulation of platelet calcium homeostasis and ROS generation by anti-estrogenic drugs tamoxifen and raloxifene”  (2007 – 2011)
 
“Tamoxifen as a modulator of calcium homeostasis in human platelets” Cancer Research and Prevention Foundation, 2005-2008.        
 
“Thrombosis in women undergoing tamoxifen chemoprevention therapy”, Virginia Commonwealth Health Research Board, 2005-2007
 
“Calcium Channels as Molecular Targets for the Anti-Thrombotic Actions of Dietary Phytoestrogens and Polyphenols”, 2003-2005, Postdoctoral Fellowship, USDA Cooperative State Research, Education and Extension Service.
 
“Mechanism of phytoestrogen action on platelet calcium channels” 2002-2003,Virginia Commonwealth Health Research Board.
 
“Dietary Phytoestrogens as novel anti-platelet, anti-thrombotic agents”, American Postdoctoral Leave Fellow, American Association of University Women Educational Foundation, 2002-2003.
 
“Regulation of platelet aggregation by phytoestrogens” (Peter F. Blackmore PI, Yuliya Dobrydneva CoPI), Jefress Memorial Trust, 1999-2002                                         
 
Virginia Academy of Science Small Project Research Fund Grant, 1998            
   

Faculty

Research in my laboratory focuses on the role of factors produced within the ovary that are essential for ovulation to occur. In the hours just before follicle rupture, the follicle destined to ovulate produces prostaglandins, which act within the follicle to stimulate ovulatory events. Our experiments examine how ovarian prostaglandins are made, where prostaglandins act within the follicle, and which important ovulatory events are triggered by prostaglandins.

 By studying prostaglandins and other ovarian factors, we hope our research will lead to better treatments for infertility as well as the development of new contraceptive options.

Professor, Physiological Sciences, 2012-Present

Associate Professor, Physiological Sciences, 2007-2012

Assistant Professor, Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, 2001-2007

Affiliate Assistant Scientist/Staff Scientist, Oregon National Primate Research Center/Oregon Health & Science University, Beaverton, OR, 1997-2001

Postdoctoral Fellow, Oregon National Primate Research Center/Oregon Health & Science University, Beaverton, OR, 1992-1997

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Eva Forgacs, PhD - Research Interests

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Ocular Pharmacology including:

 •  Retinal neovascularization diseases, such as age related macular degeneration (AMD) and retinopathy of prematurity (ROP).

•  Ocular Pharmacology including treatment for glaucoma, AMD, dry eye and cornea transplant

•  Development of a new device to monitor and treat glaucoma

•  Development of animal models for ocular pharmacology evaluations

Research Assistant Professor, EVMS Department of Physiological Sciences, 2010 - Current.

Pharmacology Instructor, EVMS Department of Physiological Sciences, 2007-present

Ocular Pharmacology Fellow, EVMS Department of Physiological Sciences, 2003-2007

General Practitioner, Ankara, Turkey 1999-2000

Faculty

Cardiovascular, cancer and ophthalmic pharmacology, including (1) treatment of ischemia and reperfusion injury (2) novel neuroprotectants for treatment of glaucoma and free radical scavengers for radiation- and chemo-protection during cancer therapy (3) development of lacritin as a treatment for dry eye (4) anti-angiogenic compounds for treatment of cancer and age related macular degeneration (5) jellyfish Aurelia aurita as a model for ototoxicity and Parkinson’s disease (6) use of optical probes and development of biomedical instruments, such as non-invasive, passive microwave devices to monitor brain temperature and telemetric intraocular pressure monitoring.

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Nearly 20% of individuals living in developed countries suffer from cardiovascular diseases such hypertension and diabetes, that are associated with increased morbidity and mortality.  Read more...

Physiopathology and cell signaling of resistance arteries

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Howard D. White, PhD - Research Interests

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