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Jorge Jacot , PHD

    • Title:
    • Assistant Professor

    • Role:
    • Faculty

    • Faculty Appointments:
    • Additional Certifications:
    • Focus Areas:
    • Office Location:
    • Lewis Hall

    • Undergraduate Education:
    • Graduate Education:
    • University of Maryland School of Medicine

      MS,  1988,  Dept. of Anatomic Pathology


      Uniformed Services University of the Health Sciences (USUHS)

      F. Edward Hebert School of Medicine, Bethesda, MD

      PhD,  1993,  Dept. of Physiology



    • Postdoctoral Education:
    • Medical Education:
    • Residency:
    • Fellowship(s):
    • National Institutes of Health (NIH),  Bethesda, MD

      Research Fellowship-National Eye Institute

      1993 - 1998

    • Board Certification(s):
    • Affiliation(s):
    • Research Interests:
    • Patents and Copyrights

      Jacot JL, O Neill JT, Reinisch L. Noninvasive method for quantitation of oxyhemoglobin saturation by near-infrared reflectance spectrophotometry (application No. US1991000713212 filed 6/11/91, issued 6/15/93).


      Sredy J, Jacot JL.  Methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis using substituted indolealkanoic acids. (No. 99,156-A).


      Vinik AI, JacotJL. Nutraceuticals for the treatment of neuropathy (submitted May 12, 2005). 


      Multi-year Consortium Budget Preparation and Calculation Worksheet Computer Program.  Certificate of Registration, June 19, 2006.



      Marketed Accomplishments

      NutriNerve:  A combination of several dietary supplement nutraceuticals prepackaged in a formulation designed for the treatment of neuropathies associated with diabetes.


      Novel Aldose Reductase Inhibitor: Discovery of a highly potent and selective Aldose Reductase Inhibitor with IND FDA-submission and Phase I clinical trials for the treatment of chronic diabetic complications.



      Outstanding Performer Scientist IPD/IDD Achievement Award  (2001)


      NIH Fellows Award for Research Excellence (1996)


      Recipient of ARVO Travel Fellowship Grant (1994 & 1996)


      Outstanding Poster Presentation Award Graduate Research Colloquium, USUHS (1992)


      Honorable Mention (1990) & Recipient (1991): The Emma L. Bockman Memorial Award for Excellence in Cardiovascular/Cancer Research



    • Primary Specialty:
    • Hospital:
    • Courses Taught:
    • Current Projects:
    • Bio:
    • Previous and Present Professional Positions


      Assistant Professor

      Dept. Pathology and Anatomy, Physiological Sciences

      Eastern Virginia Medical School

      2007 - present


      Assistant Professor

      Dept. of Internal Medicine

      Eastern Virginia Medical School (EVMS)

      2004 - 2008


      Assistant Professor

      Dept. of Physiological Sciences

      Eastern Virginia Medical School (EVMS)

      2004 - 2008


      Teaching Assistant/Instructor

      Human Anatomy & Physiology

      Univ. of Maryland at Baltimore (UMBC)

      1985 - 1989



      Pharmaceutical Experience

      Assistant Director

      Institute for Pharmaceutical Discovery (IPD): Division of Biological Science Division and Comparative Medicine.  Led an interdisciplinary research team in a multi-million dollar project for development of proprietary drug. 

      Evaluated physiological parameters in animal models for drug efficacy and for clinical end-points.

      Developed biomarkers for assay development and screening.  Experience with medical/regulatory writing and FDA IND submissions.



      Research Scientist-Biology Department-Institutes for Pharmaceutical Discovery (IPD).

      Team Leader of R&D projects.




      Other Employment

      President and CEO

      Angioceutics International, LLC

      2011 - present


      Founder and senior managing partner

      Yolar International Hospitality, LLC

      2010 - present


      Dept. of Health & Human Services

      Commission of Public Health.Washington D.C.



      Medical Consultant

      HCX, Washington D.C.



      Vol. State of MD Emergency Medical Tech/Paramedic Assistant

      BCC Rescue Squad

      1982 - 1984



Selected Publications


Jacot JL, Sherris D. Role of mTOR inhibitors in the pathophysiology of diabetic retinopathy.   Journal of Ophthalmology. 2011, Article ID 589813, 19 pages.


Jacot JL, Vinik AI. Diabetic Retinopathy: Unraveling the Paradoxical Effects of Intensive Insulin Treatment.   Insulin 2007, vol 2. no1. 4-11.


Van Zandt MC, Jones ML, Gunn DE, Geraci LS, Jones H, Sawicki DR, Sredy J, Jacot JL, DiCioccio T, Petrova T, Mitschler A, Podjarny AD. Discovery of 3-[(4,5,7-Trifluorobenzothiazol-2-yl)methyl]indole-N- acetic acid (Lidorestat) and Cogeners as Highly Potent and Selective Inhibitors of Aldose Reductase for Treatment of Chronic Diabetic Complications.   J. Med. Chem 2005, 48, 3141-3152.


Jacot JL, Sredy J. Emerging Therapeutics for Diabetic Retinopathy: Potential Therapies for the New Millennium.   Emerging Therapeutic Targets 3(2):307-335, 1999 (Review).


Jacot JL, O'Neill T.J., Scandling D.M., West S.D., McKenzie J.E. Nitric Oxide Modulation of Retinal, Choroidal, and Anterior Uveal Blood Flow in Newborn Piglets.   J. of Ocular Pharm.& Therap14(5):473,1998.


Jacot JL, Hosotani H, Glover JP, Lois N, Robison WG Jr. Diabetic-Like Corneal Sensitivity Loss in Galactose-Fed Rats Ameliorated with Aldose Reductase Inhibitors.   Journal of Ocular Pharmacol & Therapeutics 14(2):169-180, 1998.


Jacot JL, Glover JP, Robison WG Jr. Computer Analysis of Corneal Innervation Density Using a Novel Double Stain in Rat Corneal Whole Mounts.   Journal of Anatomy,191, 191-199, 1997.


Jacot JL, Laver NM, Glover JP, Lazarous DF, Scheinowitz M, Unger EF, Robison WG Jr. Histological Evaluation of the Canine Retinal Vasculature Following Chronic Systemic Administration of Basic Fibroblast Growth Factor.   Journal of Anatomy, 188:349-354, 1996.


Jacot JL, Glover JP, Robison WG Jr. Improved Gold Chloride Procedure for Optimal Preservation of Nerve Staining in Whole Mounts of Rat Corneas.   Biotechnic & Histochemistry, 70(6):277-284, 1995.