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Dianne C. Daniel , PhD

    • Title:
    • Associate Professor

    • Role:
    • Faculty

    • Faculty Appointments:
    • Additional Adjunct Appointment:

      Department of Pathology
      Mount Sinai School of Medicine
      New York, NY

    • Additional Certifications:
    • Focus Areas:
    • Office Location:
    • Lewis Hall

    • Undergraduate Education:
    • Graduate Education:
      • B.S., Lynchburg College, Lynchburg, VA
      • M.S., Longwood College, Farmville, VA
      • Ph.D., City University of New York, New York, NY
    • Postdoctoral Education:
      • Mount Sinai School of Medicine and The Rockefeller University, New York, NY
    • Medical Education:
    • Residency:
    • Fellowship(s):
    • Board Certification(s):
    • Affiliation(s):
    • Research Interests:
    •  
      Principal Investigator
      Co-regulation and function of Pur-gamma and WRN in the CNS
       
      We are studying the Pur family member, Pur-gamma, in regard to cancer, aging and neurological disorders associated with AIDS. The Pur-gamma gene is located head to head with the WRN gene, and the two proteins share a common promoter region. We are investigating the concurrent regulation of these genes and their functional interaction. Current Funding: NIH
       
      Cellular, molecular and biochemical analysis of MCM8 function
       
      The role of the minichromosome maintenance (MCM) proteins in initiation of DNA replication has been extensively studied, and the MCM2-7 heterohexamer is proposed to be a replicative helicase unwinding DNA ahead of the replication fork during S phase. Additional functions are currently being ascribed to these family members. In 2003, we discovered the gene for MCM8, a new family member that is not found in yeast, but which has seemly evolved to adapt to the more complex nuclear structure of higher eukaryotes. We, and others, have shown the MCM8 gene to be either mutated or variantly spliced in a choriocarcinoma and virally interrupted in a hepatocarcinoma, respectively. The archael MCM proteins, MCM2-7 and MCM8 proteins are AAA+ (ATPases associated with a variety of cellular activities) enzymes. MCM8 is unique among the family members in that it has intrinsic in vitro helicase activity without the presence of family members MCM2-7. MCM8 interacts with proteins involved in DNA replication, including Cdc6, RPA, Cdk2 and other MCM family members. We are studying MCM8 in the context of development and human disease.  Funded: CHRB
       
      Co-investigator
      Adaptive Mechanism of DNA Replication-driven Recombination Alters JCV
      Control Region Sequences, EM Johnson, PI, Funding: The PML Consortium
       
      Using Induced Pluripotent Stem Cells to Develop a Therapy for ALS, EW Godfrey, PI, Funding: Crystal Ball, Inc
    • Primary Specialty:
    • Hospital:
    • Courses Taught:
    •  

      Biomedical Sciences Program Track:
      Molecular Integrative Biosciences (MIB)

       
      Course Director
      Biotechnology Program--Research Design
       
      Medical Students
      Medical Molecular Cell Biology/Cell Structure and Function (DNA Replication lectures)
      Medical Biochemistry small groups (14)
      Microbiology and Immunology laboratory facilitator
      Genetics Small Groups or Team Based Learning
       
      Medical Masters
      Library Thesis Research Paper
      Medical Biochemistry small groups (14)
       
      Graduate (Ph.D. and Research Masters)
      Medical Molecular Cell Biology/Cell Structure and Function (DNA Replication lectures)
      Medical Biochemistry small groups (14)
      Advanced Cell Biology (1 lecture and small group)
      Research Techniques (2 lectures)
      Journal Club mentor
      Introduction to the Research Literature (presentation and discussion)
    • Current Projects:
    • Bio:

Publications

Administrative/Service

Executive Committee Faculty Senate
---Member-at-large
Faculty Senator
Internal Review Board, EVMS
Medical Student Interview Panels