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Julia A. Sharp , PhD

    • Title:
    • Assistant Professor

    • Role:
    • Faculty

    • Faculty Appointments:
    • Microbiology and Molecular Cell Biology

      School of Health Professions

    • Additional Certifications:
    • Focus Areas:
    • Office Location:
    • Lewis Hall

    • Undergraduate Education:
    • Graduate Education:
    • MS Biology, Old Dominion University

      PhD Biomedical Sciences, EVMS

    • Postdoctoral Education:
    • Microbiology and Molecular Cell Biology, EVMS

    • Medical Education:
    • Residency:
    • Fellowship(s):
    • Board Certification(s):
    • Affiliation(s):
    • Research Interests:
    • Complement evasion; Complement inhibition (peptide delivery); the effect of stress on Complement

    • Primary Specialty:
    • Hospital:
    • Courses Taught:
    • BP718/818, BT 702: Intro to Lab (Course Director)

      BT 706: Advanced Molecular and Cellular Techniques (Course Director)

      BT 708: Microarray Technologies

      MIC 202: Medical Microbiology

      MLAS 509: Biotechnology and Diagnostic Techniques

      RCS 702: Molecular Biology and Genetics

      MSA 503: Surgical Microbiology

    • Current Projects:
    • Bio:
  1. Sharp JA, Hair PS, Pallera HK, Kumar PS, Mauriello CT, Nyalwidhe JO, Phelps CA, Park D, Thielens NM, Pascal SM, Chen W, Lattanzio FA, Cunnion KM, and NK Krishna.  2015.  Peptide Inhibitor of Complement C1 (PIC1) rapidly inhibits complement activation after intravascular injection in rats. PLoS ONE 10(7): e0142466. doi: 10.1371/journal.pone.0132446
  2. Sharp JA, Whitley PH, Cunnion KM and NK Krishna. 2014. Peptide inhibitor of complement C1 (PIC1), a novel suppressor of classical pathway activation: mechanistic studies and clinical potential. Front. Immunol. 5:406. doi: 10.3389/fimmu.2014.00406
  3. Shah TA, Mauriello CT, Hair PS, Sharp JA, Kumar PS, Lattanzio FA, Werner AL, Whitley PH, Maes LA, Cunnion KM, and NK Krishna. 2014. Complement inhibition significantly decreases red blood cell lysis in a rat model of acute intravascular hemolysis. Transfusion. doi: 10.1111/trf.12695
  4. Mauriello CT, Pallera HK, Sharp JA, Woltmann Jr JL, Qian S, Hair PS, van der Pol P, van Kooten C, Thielens NM, Lattanzio FA, Cunnion KM, and NK Krishna. 2012.  A novel peptide inhibitor of classical and lectin complement activation including ABO incompatibility. Mol Immunol 53:132-139
  5. Sharp JA, Echague CG, Hair PS, Ward MD, Nyalwidhe JO, Geoghegan JA, Foster, TJ and KM Cunnion. 2012. Staphylococcus aureus surface protein SdrE binds complement regulator factor H as an immune evasion tactic. PLoS ONE 7(5): e38407. doi:10.1371/journal.pone.0038407
  6. Sharp JA and KM Cunnion. 2011. Disruption of the alternative pathway convertase occurs at the staphylococcal surface via the acquisition of factor H by Staphylococcus aureus. Mol Immunol 48:683-690